Association between chronic periodontitis and serum lipid levels

Abstract

This study confirms a significant relationship between periodontal disease, regardless its intensity, and blood lipid levels in the studied population. The results imply that periodontitis may be a risk factor and may contribute to the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). However, future prospective randomized studies have to determine whether periodontal disease is a risk factor for the occurence of CVD.

Association between periodontitis and hyperlipidaemia: A systematic review and meta‐analysis

“…All studies examined a total of 4836 participants, including 2060 patients with PD and 2776 healthy controls. Newcastle-Ottawa Scale (NOS) scores in our study included 8 points in 19 studies [7][8][9][11][12][13]15,17,[19][20][21][22][23][25][26][27][30][31][32] and 6 points in 10 studies. 6,10,14,16,18,24,28,29,33,34…”

“…Twenty-nine studies on the association between PD and serum TG level were published between 1999 and 2018, and involved a total of 4836 cases, including 2060 patients with PD and 2776 healthy participants ( Table 1). There was a variation in their geographical locations including the USA (n = 1), 6 Germany (n = 1), 7 Srbija (n = 1), 19 Austria (n = 1), 21 Colombia (n = 1), 27 Turkey (n = 2), 11,29 Brazil (n = 3), 8,13,31 Iran (n = 4), 9,15,16,23 China (n = 5) 10,12,18,20,30 and India (n = 10) 14,17,22,[24][25][26]28,[32][33][34] (Table 1). For statistical analysis, we divided one study into two or three comparison groups according to the severity of PD (light, moderate and severe).…”

“…30 comparison groups from 26 studies were summarized in Figure 3A, which were published between 1999 and 2018, and involved 2024 cases with PD and 2738 healthy controls. One study was conducted in the USA, 6 one in Germany, 7 one in Turkey, 11 one in Srbija, 19 one in Austria, 21 one in Colombia, 27 three in Brazil, 8,13,31 four in Iran, 9,15,16,23 five in China 10,12,18,20,30 and eight in India 17,22,25,26,28,[32][33][34] ( Table 1). The pooled WMD was 15.4 mg/dL (95% CI 10.2-20.6 mg/dL, P = .000) ( Figure 3A), indicating that PD was significantly associated with high serum TC level.…”

“…Twenty-seven comparison groups from 25 studies analyzed serum LDL level between 2000 and 2017, and included a total of 1710 patients and 2625 healthy cases. One study was conducted in Germany, 7 one in Srbija, 19 one in Austria, 21 one in Colombia, 27 two in Turkey, 11,29 three in Brazil, 8,13,31 four in Iran, 9,15,16,23 four in China 12,18,20,30 and eight in India 15,22,[24][25][26]28,32,33 ( Table 1). The pooled WMD for serum LDL level in the PD and HC groups was 11.7 mg/dL (95% CI 8.3-15.0 mg/dL, P = .000) (Figure 4), suggesting PD was significantly associated with high serum LDL level.…”

Asociación entre hipertensión arterial y periodontitis

“…enfermedades cardiovasculares y cerebrovasculares suponen un gran problema de salud en la sociedad actual y se consideran la primera causa de mortalidad (1,2) .…”