Association between chronic pain with presarcopenia and central sensitization in Japanese community-dwelling older adults: A cross-sectional study

Imai, Ryota; Imaoka, Masakazu; Nakao, Hidetoshi; Hida, M.; Tazaki, Fumie; Inoue, Takao; Orui, Junya; Nakamura, Misa

doi:10.1097/md.0000000000029998

Cited by 5 publications

(10 citation statements)

References 32 publications

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“…The list of excluded studies and their respective reasons of exclusion is available on our Open Science Framework deposit (https://osf.io/rqhvy/). Therefore, a total of 43 observational studies were included in this systematic review, 42 cross‐sectional studies 5,27–67 and one prospective study 68 for which baseline values of HRQoL for the sarcopenic and non‐sarcopenic groups were used (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis

Beaudart

Demonceau

Reginster

et al. 2023

J cachexia sarcopenia muscle

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The decrease of physical abilities and functional decline that can be caused by musculoskeletal conditions such as sarcopenia, can lead to higher levels of dependency and disability. Therefore, it may influence patient reported outcome measures (PROM), such as the health‐related quality of life (HRQoL). The purpose of this systematic review and meta‐analysis is to provide a comprehensive overview of the relationship between sarcopenia and HRQoL. Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) were followed throughout the whole process of this work. A protocol was previously published on PROSPERO. The electronic databases MEDLINE, Scopus, Allied and Complementary Medicine (AMED), EMB Review – ACP Journal Club, EBM Review ‐ Cochrane Central of Register of Controlled Trials and APA PsychInfo were searched until October 2022 for observational studies reporting a HRQoL assessment in both sarcopenic and non‐sarcopenic individuals. Study selection and data extraction were carried out by two independent researchers. Meta‐analysis was performed using a random effect model, reporting an overall standardized mean difference (SMD) and its 95% confidence interval (CI) between sarcopenic and non‐sarcopenic individuals. Study quality was measured using the Newcastle‐Ottawa Scale and the strength of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. The search strategy identified 3725 references from which 43 observational studies were eligible and included in this meta‐synthesis study. A significantly lower HRQoL was observed for sarcopenic individuals compared with non‐sarcopenic ones (SMD −0.76; 95% CI −0.95; −0.57). Significant heterogeneity was associated with the model (I2 = 93%, Q test P‐value <0.01). Subgroup analysis showed a higher effect size when using the specific questionnaire SarQoL compared with generic questionnaires (SMD −1.09; 95% CI −1.44; −0.74 with the SarQoL versus −0.49; 95% CI −0.63; −0.36 with generic tools; P‐value for interaction <0.01). A greater difference of HRQoL between sarcopenic and non‐sarcopenic was found for individuals residing in care homes compared with community‐dwelling individuals (P‐value for interaction <0.001). No differences were found between age groups, diagnostic techniques, and continents/regions. The level of evidence was rated as moderate using the GRADE assessment. This systematic review and meta‐analysis combining 43 observational studies shows that HRQoL is significantly reduced in sarcopenic patients. The use of disease‐specific HRQoL instruments may better discriminate sarcopenic patients with respect to their quality of life.

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Section: Resultsmentioning

confidence: 99%

Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis

Beaudart

Demonceau

Reginster

et al. 2023

J cachexia sarcopenia muscle

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“…Increased lean muscle mass is known to be associated with reduced migraine frequency [64,65]. Moreover, increment/preservation of lean body mass has been shown to combat central sensitization in chronic pain syndromes [66]. This indicates that the type of weight loss determines the efficacy of exercise interventions.…”

Section: Discussionmentioning

confidence: 99%

What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials

Woldeamanuel

Oliveira

2022

J Headache Pain

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Background Multiple clinical trials with different exercise protocols have demonstrated efficacy in the management of migraine. However, there is no head-to-head comparison of efficacy between the different exercise interventions. Methods A systematic review and network meta-analysis was performed involving all clinical trials which determined the efficacy of exercise interventions in reducing the frequency of monthly migraine. Medical journal search engines included Web of Science, PubMed, and Scopus spanning all previous years up to July 30, 2022. Both aerobic and strength/resistance training protocols were included. The mean difference (MD, 95% confidence interval) in monthly migraine frequency from baseline to end-of-intervention between the active and control arms was used as an outcome measure. Efficacy evidence from direct and indirect comparisons was combined by conducting a random effects model network meta-analysis. The efficacy of the three exercise protocols was compared, i.e., moderate-intensity aerobic exercise, high-intensity aerobic exercise, and strength/resistance training. Studies that compared the efficacy of migraine medications (topiramate, amitriptyline) to exercise were included. Additionally, the risk of bias in all included studies was assessed by using the Cochrane Risk of Bias version 2 (RoB2). Results There were 21 published clinical trials that involved a total of 1195 migraine patients with a mean age of 35 years and a female-to-male ratio of 6.7. There were 27 pairwise comparisons and 8 indirect comparisons. The rank of the interventions was as follows: strength training (MD = -3.55 [− 6.15, − 0.95]), high-intensity aerobic exercise (-3.13 [-5.28, -0.97]), moderate-intensity aerobic exercise (-2.18 [-3.25, -1.11]), topiramate (-0.98 [-4.16, 2.20]), placebo, amitriptyline (3.82 [− 1.03, 8.68]). The RoB2 assessment showed that 85% of the included studies demonstrated low risk of bias, while 15% indicated high risk of bias for intention-to-treat analysis. Sources of high risk of bias include randomization process and handling of missing outcome data. Conclusion Strength training exercise regimens demonstrated the highest efficacy in reducing migraine burden, followed by high-intensity aerobic exercise.

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“…Prevalence data for sarcopenia were extracted from 11 remaining studies (n=29,832), 13,16,17,20,[22][23][24][25][26]29,30 yielding a cumulative prevalence of 0.11 (95% CI, 0.08-0.14) (Figure 2). Subgroup analysis revealed a slightly higher prevalence of sarcopenia in low-and middle-income countries (0.12, 95% CI, 0.09-0.16) than in high-income countries (0.11, 95% CI, 0.07-0.15).…”

Section: Prevalence Of Sarcopenia Among Older Adults With Chronic Painmentioning

confidence: 99%

“…11 Furthermore, there appear to be shared pathophysiological mechanisms between sarcopenia and chronic pain, such as elevated circulating levels of pro-inflammatory factors and oxidative stress. 12,13 The relationship between sarcopenia and chronic pain has not yet been clearly elucidated. Studies have shown that people with sarcopenia tend to report higher rates of pain compared to non-sarcopenic populations.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia and Chronic Pain in the Elderly: A Systematic Review and Meta-Analysis

Chen,

Wang,

2023

JPR

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Sarcopenia and chronic pain are prevalent among older adults, and despite numerous studies, the potential epidemiological link between the two conditions remains a topic of controversy. Therefore, we performed a comprehensive systematic review and meta-analysis to assess the relationship between chronic pain and sarcopenia in the elderly. Methods: EMBASE, Web of Science, PubMed, and the Cochrane Library were searched through 22 March 2023 with additional manual searches of reference lists of included studies and relevant reviews. We used a random effects model to conduct the metaanalysis and evaluated heterogeneity across studies with Cochran's Q statistic and I 2 . Subgroup analyses were conducted based on income level, diagnostic criteria for sarcopenia, and pain site. Results: 17 observational studies (33,600 participants, 49% female) were included, of which 6 articles were retrieved for narrative review. The pooled prevalence of sarcopenia and the pooled odds ratios (OR) between chronic pain and sarcopenia were extracted from the remaining 11 studies. The pooled prevalence of sarcopenia among older adults suffering from chronic pain was 0.11 (95% CI, 0.08-0.18). Our analysis revealed a statistically significant positive association between chronic pain and an increased risk of sarcopenia, yielding a pooled OR of 1.52 (95% CI, 1.31-1.76). Furthermore, our subgroup analysis demonstrated that the lowincome countries group showed a stronger association (OR, 1.73; 95% CI, 1.54-1.95) between chronic pain and sarcopenia than the high-income countries group (OR, 1.38; 95% CI, 1.20-1.60). Conclusion: Older adults with chronic pain have a significantly higher prevalence of sarcopenia and risk of developing sarcopenia compared to those without pain. These findings highlight the importance of prioritizing the assessment and early detection of chronic pain in older people, as well as implementing proactive intervention measures in clinical practice. In addition, our results suggest that older people with chronic pain should be actively screened for sarcopenia. Prospero Registration Number: CRD42021239807.

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Association between chronic pain with presarcopenia and central sensitization in Japanese community-dwelling older adults: A cross-sectional study

Cited by 5 publications

References 32 publications

Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis

Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis

What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials

Sarcopenia and Chronic Pain in the Elderly: A Systematic Review and Meta-Analysis

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