Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population

Akgöllü, Ersin; Bilgin, Ramazan; Akkız, Hikmet; Ülger, Yakup; Kaya, Berrin Yalınbaş; Karaoğullarından, Ümit; Arslan, Yusuf

doi:10.1016/j.virusres.2017.01.017

Cited by 15 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in contrast to the study of Al‐Qahtani et al, who did not find a significant association of rs3077 with HBV clearance in a Saudi Arabian population (n = 1672) with genetic characteristics similar to Caucasians. Similarly, one study including European Americans (n = 505) and another recent study in a Turkish Caucasian population (n = 528) found no association of rs3077 with persistent HBV infection . In our study, this finding remained significant even after excluding the subjects from the Middle East and the Mediterranean region.…”

Section: Discussionsupporting

confidence: 57%

“…This is in contrast to the results of studies on Asian populations, but is partially in agreement with the results of other studies conducted on individuals of Caucasian origin. Thus, the data from a European American population indicated only a weak association of this SNP with HBV clearance, and a recent Turkish study also found a marginal effect but solely in terms of allelic distributions . Al‐Qahtani et al found only an association with HBV susceptibility in a Saudi Arabian population, but no association with HBsAg clearance, whereas a German study found no association with HBV susceptibility either .…”

Section: Discussionmentioning

confidence: 94%

“…Furthermore, age‐matched analysis revealed an increase in power of the association with persistence of HBV infection (OR 0.459, 95% CI 0.257‐0.818; P = 0.008). Because there is no general agreement on Caucasian populations, we conducted a subanalysis excluding the subjects from the Middle East and the Mediterranean region. The logistic regression analysis in the remaining population (384 in the CHB group and 218 in the SC group) adjusted for age and gender also revealed an association of the rs3077‐C allele with persistence of HBV infection (OR 0.661, 95% CI 0.441‐0.991, P = 0.045; Table ).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Koukoulioti

Fischer

Schott

et al. 2019

Liver International

View full text Add to dashboard Cite

Background & Aims Acute hepatitis B virus (HBV) infections may clear spontaneously or become chronic and run through different phases. The single nucleotide polymorphisms (SNPs) rs3077, rs9277535 and rs9277534 within the human leucocyte antigen (HLA)‐DP gene have been found to be associated with HBV susceptibility and persistence in Asians. However, evidence for the influence of these variants in Caucasians has been limited so far. The aim of our study was to investigate the impact of these polymorphisms on the outcome of HBV infections in a large Caucasian population. Methods In this case‐control study, we retrospectively analysed 1111 Caucasian individuals, including 618 with chronic HBV infections (CHB), 239 with spontaneous HBsAg seroclearance (SC) and 254 healthy controls (HC). The rs3077, rs9277535 and rs9277534 SNPs were genotyped by a polymerase chain reaction from blood samples and melting curve analysis. Results A significant difference in the allele distributions was observed only for the rs3077 SNP between the HC and the CHB group as well as between the SC and CHB groups. The rs3077‐C allele was associated with a lower probability for spontaneous HBsAg seroclearance in comparison with the rs3077‐T allele (OR 0.704, 95% CI 0.509‐0.974; P = 0.033). No association of the three SNPs with the stages of chronic HBV infection was found. Conclusion This is the first study demonstrating an association of the rs3077‐T allele with spontaneous HBsAg seroclearance in Caucasians. Further studies are needed to elucidate the role of HLA‐DP variants in disease pathogenesis and their potential role for individualized disease management.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Koukoulioti

Fischer

Schott

et al. 2019

Liver International

View full text Add to dashboard Cite

show abstract

“…Several routes of transmission have been reported, but most people in Taiwan are believed to have acquired the virus early in life . Genetic variation, environmental factors and genome variability are some of the multiple factors that influence chronic HBV infection . There exist remarkable differences in the geographical distribution of HBV genotypes …”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Nfor

Debnath

et al. 2018

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV) infection. NTCP rs2296651 is believed to be an Asian-specific variant responsible for HBV susceptibility. We investigated the relationship between rs2296651 and HBV infection in Taiwan based on stratification by gender and menopausal status. We recruited 10 017 Taiwan Biobank participants aged 30-70 years with complete genetic data and sociodemographic information. Gender-stratified multivariate logistic regression models were used to determine the relationship between NTCP variant and HBV infection. Among individuals with HBV infection, the genotype frequencies of GG, AG and AA in women were 0.85, 0.15 and 0 while those in men were 0.82, 0.18 and 0, respectively. The multivariate-adjusted odds ratios (OR) of HBV infection were 0.77 (95% CI 0.59-0.10) in women and 0.98 (95% CI 0.79-1.20) in men. The adjusted OR was 0.87 (CI 0.63-1.19) in premenopausal and 0.59 (0.36-0.97) in postmenopausal women. We found that genetic variation in the HBV receptor gene (NTCP) was significantly associated with a decreased risk of HBV infection in Taiwanese women.

show abstract

“…The DPB1 gene is a member of the major histocompatibility complex (MHC) class II genes, which play an important role in presenting antigen to CD4+ T lymphocytes. One study performed in a Korean population reported that the HLA‐DPB1*1301 and DPB1*0901 alleles were highly associated with the susceptibility to systemic sclerosis (SSc), and a study in a Turkish population showed the HLA‐DPB1 gene rs9277535A allele to have a profound effect on the risk of persistent hepatitis B virus (HBV) infection . The rhesus macaque MHC‐DPB1 allele ( Mamu‐DPB1*01 ) was found to be involved in susceptibility to experimental autoimmune encephalomyelitis (EAE) in rhesus macaques .…”

mentioning

confidence: 99%

Identification of eight new MHC‐DPB1 alleles in the Tibetan macaques (Macaca thibetana)

Yao

Zhou

et al. 2018

HLA

View full text Add to dashboard Cite

show abstract

Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population

Cited by 15 publications

References 31 publications

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Hepatitis B virus infection in Taiwan: The role of NTCP rs2296651 variant in relation to sex

Identification of eight new MHC‐DPB1 alleles in the Tibetan macaques (Macaca thibetana)

Contact Info

Product

Resources

About