Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Abstract

Background & Aims Acute hepatitis B virus (HBV) infections may clear spontaneously or become chronic and run through different phases. The single nucleotide polymorphisms (SNPs) rs3077, rs9277535 and rs9277534 within the human leucocyte antigen (HLA)‐DP gene have been found to be associated with HBV susceptibility and persistence in Asians. However, evidence for the influence of these variants in Caucasians has been limited so far. The aim of our study was to investigate the impact of these polymorphisms on the outcome of HBV infections in a large Caucasian population. Methods In this case‐control study, we retrospectively analysed 1111 Caucasian individuals, including 618 with chronic HBV infections (CHB), 239 with spontaneous HBsAg seroclearance (SC) and 254 healthy controls (HC). The rs3077, rs9277535 and rs9277534 SNPs were genotyped by a polymerase chain reaction from blood samples and melting curve analysis. Results A significant difference in the allele distributions was observed only for the rs3077 SNP between the HC and the CHB group as well as between the SC and CHB groups. The rs3077‐C allele was associated with a lower probability for spontaneous HBsAg seroclearance in comparison with the rs3077‐T allele (OR 0.704, 95% CI 0.509‐0.974; P = 0.033). No association of the three SNPs with the stages of chronic HBV infection was found. Conclusion This is the first study demonstrating an association of the rs3077‐T allele with spontaneous HBsAg seroclearance in Caucasians. Further studies are needed to elucidate the role of HLA‐DP variants in disease pathogenesis and their potential role for individualized disease management.

Clinical Significance of HLA DPB1 (SNPrs3116996 & SNPRs2071025) Gene Polymorphism in Liver Cirrhosis Development among Egyptian Patients with Chronic HCV Infection

“…So, it may have a protective role against development of chronic HCV infection and deterioration of post-HCV liver cirrhosis. This comes in agreement with Koukoulioti et al [24] who found in their study that T allele may have a protective role.…”

Functional Cure of Hepatitis B Virus Infection in Individuals With HIV-Coinfection: A Literature Review

“…Several studies have found that genetic variants on the human leucocyte antigen (HLA)-DP gene are associated with HBsAg-seroclearance during the natural history of infection [ 64 ] or during treatment with NA [ 65 ], which seems to be consistent across different populations [ 66 ]. Other polymorphisms on genes linked to immunological function, such as the toll-like receptor 3 [ 67 ], interleukin 10 [ 68 ], and T-cell immunoglobulin and mucin domain-containing molecule 3 genes [ 69 ], have also shown to be linked to the natural progression of HBV infection and are less consistently studied [ 66 ].…”

EBV protection‐ and susceptibility‐related HLA alleles and EBV status in the Chinese population: A single‐center study

“… 4 Thus, there is a strong link between HLA alleles and various diseases, including infections, autoimmune diseases, and tumors. 5 …”

“…The evolution of HLA molecular polymorphisms is thought to be the result of selection and adaptation via the modulation of host immunity against infections, tumors, and other diseases 4 . Thus, there is a strong link between HLA alleles and various diseases, including infections, autoimmune diseases, and tumors 5 …”

“…4 Thus, there is a strong link between HLA alleles and various diseases, including infections, autoimmune diseases, and tumors. 5 Latent Epstein-Barr virus (EBV) infection is present in over 90% of the world's adult population. Social/economic factors and the genomic make-up of individuals can influence susceptibility to viral infection and the outcome of infection.…”