Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: A <scp>US</scp> population‐based study

Silverberg, Jonathan I.

doi:10.1111/pai.12315

Cited by 40 publications

(31 citation statements)

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“…Atopic disease has been shown to be associated with several different comorbid conditions, many of which are known to increase the risk for anemia. The chronic inflammation present in atopic disease, use of systemic immunosuppressant medications, increased incidence of malnutrition 17,21,22 and/or obesity, [6][7][8] and increased use of alternative medicines 23 are examples of such comorbidities. Nevertheless, there is a paucity of data examining the association between atopic disease and anemia.…”

Section: Discussionmentioning

confidence: 99%

“…Regardless of the underlying mechanisms, awareness of the association between atopic disease and anemia is important. Physicians who care for children with atopic disease should be aware that fatigue may be related to unrecog- 17,21,22,24 and that patients with atopic disease are at an increased risk for low bone mineral density 17,18,25 and vitamin D deficiency. 26,27 Iron deficiency anemia is estimated to affect 3% of US children aged 1 to 2 years and is the most common type of microcytic anemia in childhood.…”

Section: Discussionmentioning

confidence: 99%

“…It has been established that diets devoid of milk products and other crucial foods can lead to malnutrition. 17,21,22 In our study, history of food allergy was assessed by caregiver report that did not depend on a previous health care diagnosis of food allergy. Thus, it is possible that some or many of the children reported as having food allergies were not true food allergies.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Some patients with atopic disease are at higher risk for low bone mineral density. 17,18 All these factors have been shown to be associated with anemia. In addition, children with moderate to severe eczema are often treated with long-term immunosuppressant medications, such as methotrexate and cyclosporine, which can cause anemia and other hematologic abnormalities.…”

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confidence: 99%

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Association Between Atopic Disease and Anemia in US Children

2016

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IMPORTANCE Atopic disease is associated with chronic inflammation, food allergen avoidance, and use of systemic immunosuppressant medications. All these factors have been shown to be associated with anemia. OBJECTIVE To investigate whether atopic disease is associated with increased risk of childhood anemia. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional survey and laboratory assessment were conducted using data from the 1997-2013 US National Health Interview Survey (NHIS) that included 207 007 children and adolescents and the 1999-2012 National Health and Nutrition Examination Survey (NHANES) that included 30 673 children and adolescents. Analysis of the data was conducted between August 1, 2014, and August 28, 2015. EXPOSURES Caregiver-reported history of eczema, asthma, hay fever, and/or food allergy. MAIN OUTCOMES AND MEASURES Anemia was defined by caregiver report in the NHIS and by hemoglobin levels for age and sex in the NHANES. RESULTS Data were collected on 207 007 children and adolescents from NHIS, representing all pediatric age, sex, racial/ethnic, household educational level, and income groups. The US prevalence was 9.5% (95% CI, 9.4%-9.7%) from all years of the NHIS for health care-diagnosed eczema, 12.8% (95% CI, 12.6%-13.0%) for asthma, 17.1% (95% CI, 16.9%-17.3%) for hay fever, 4.2% (95% CI, 4.1%-4.3%) for food allergy, and 1.1% (95% CI, 1.1%-1.2%) for anemia. In multivariable logistic regression models controlling for age, sex, race/ethnicity, annual household income, highest educational level in the family, insurance coverage, number of persons in the household, birthplace in the United States, and history of asthma, hay fever, and food allergy, anemia was associated with eczema in 14 of 17 studies, asthma in 11, hay fever in 12, and food allergy in 12. In multivariable analysis across the NHIS (with results reported as adjusted odds ratios [95% CIs]), children with any eczema (1.83; 1.58-2.13), asthma (1.31; 1.14-1.51), hay fever (1.57; 1.36-1.81), and food allergy (2.08; 1.71-2.52) had higher odds of anemia (P < .001 for all). In the NHANES, current history of asthma (1.33; 1.04-1.70; P = .02) and eczema (1.93; 1.04-3.59; P = .04) were associated with higher odds of anemia, particularly microcytic anemia (asthma: 1.61; 1.09-2.38; P = .02; eczema: 2.03; 1.20-3.46; P = .009) while history of hay fever was not associated with anemia (0.85; 0.62-1.17; P = .33). CONCLUSIONS AND RELEVANCE The association between atopic disease and anemia was reproducible in multiple cohorts. Future studies are needed to identify the determinants of association between atopic disease and anemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association Between Atopic Disease and Anemia in US Children

2016

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“…Although we did not find an association between SCORAD and 25(OH)D or iPTH, it is interesting to include iPTH in studies like the one that this letter is commenting on . Silverberg found that children with AD had no difference in PTH from controls, but AD severity was not assessed. We have not found studies investigating the action of PTH on the atopic skin barrier.…”

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confidence: 64%

Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research

Mesquita

Igreja

Costa

2016

Pediatric Dermatology

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Automatic skin disease diagnosis using deep learning from clinical image and patient information

Muhaba

Dese

Aga

et al. 2021

Skin Health and Disease

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Background: Skin diseases are the fourth most common cause of human illness which results in enormous non-fatal burden in daily life activities. They are caused by chemical, physical and biological factors. Visual assessment in combination with clinical information is the common diagnostic procedure for diseases. However, these procedures are manual, time-consuming, and require experience and excellent visual perception. Objectives: In this study, an automated system is proposed for the diagnosis of five common skin diseases by using data from clinical images and patient information using deep learning pre-trained mobilenet-v2 model. Methods: Clinical images were acquired using different smartphone cameras and patient's information were collected during patient registration. Different data preprocessing and augmentation techniques were applied to boost the performance of the model prior to training. Results: A multiclass classification accuracy of 97.5%, sensitivity of 97.7% and precision of 97.7% has been achieved using the proposed technique for the common five skin disease. The results demonstrate that, the developed system provides excellent diagnosis performance for the five skin diseases. Conclusion:The system has been designed as a smartphone application and it has the potential to be used as a decision support system in low resource settings, where both the expert dermatologist and the means are limited. | INTRODUCTIONSkin is the largest organ of the body which provides protection, regulates the body fluids and temperature, and enables sense of the external environment. 1 Skin diseases are the most common cause of all human illnesses which affects almost 900 million people in the world at any time. 2 According to the global burden of disease project, skin disease is the fourth leading cause of non-fatal disease burden throughout the world. 3 An estimated 21%-87% of children in Africa are affected by skin diseases. 4 Skin disease can cause financial, socio-economic, and psychological burden to the community and place a strain on health professionals. [5][6][7][8][9][10][11][12] Moreover, skin diseases may cause a sense of depression, frustration, isolation, and even suicidal ideation. 13 The pattern of skin diseases varies due to environmental factors, hygienic standards, social customs, and genetics. In developing countries, infection and infestation are more common. 4 There are more than 3000 known skin diseases worldwide. 14 According to a preliminary study conducted for this research, acne vulgaris, atopic dermatitis, lichen planus, onychomycosisThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: A US population‐based study

Abstract: Children with AD have lower BMD, particularly those with malnutrition and Hispanic ethnicity.

Cited by 40 publications

References 16 publications

Association Between Atopic Disease and Anemia in US Children

Association Between Atopic Disease and Anemia in US Children

Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research

Automatic skin disease diagnosis using deep learning from clinical image and patient information

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