Association Between Child Abuse and Risk of Adult Coronary Heart Disease: A Systematic Review and Meta-Analysis

Chen, Yinxian; Shan, Yuxi; Lin, Kehuan; Wang, Ying; Kim, Hyelee; Gelaye, Bizu; Papatheodorou, Stefania

doi:10.1016/j.amepre.2023.02.028

Cited by 6 publications

(1 citation statement)

References 72 publications

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“…Notably, compelling evidence supports ACE-induced vascular endothelial dysfunction, characterized by increased arterial stiffness, higher peripheral vascular resistance, and reduced endothelial function (2,3). Such dysfunction primes for the development of cardiovascular disease later in life (2,(4)(5)(6)(7)(8)(9)(10). The observed correlation between ELA and cardiovascular disease is physiologically sound.…”

Section: Introductionmentioning

confidence: 97%

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

Wakid,

Almeida,

Denniston

et al. 2024

Preprint

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Exposure to early life adversity (ELA) poses a significant global public health concern, with profound pathophysiological implications for affected individuals. Studies suggest that ELA contributes to endothelial dysfunction, bringing into question the functional integrity of the neurovascular unit in brain regions vulnerable to chronic stress. Despite the importance of the neurovasculature in maintaining normal brain physiology, human neurovascular cells remain poorly characterized, particularly with regard to their contributory role in ELA-associated pathophysiologies. In this study, we present the first comprehensive transcriptomic analysis of intact microvessels isolated from postmortem ventromedial prefrontal cortex samples from adult healthy controls (CTRL) and matched depressed suicides with histories of ELA. Our findings point to substantive differences between men and women, with the latter exhibiting widespread gene expression changes at the neurovascular unit, including the key vascular nodal regulators KLF2 and KLF4, alongside a broad downregulation of immune-related pathways. These results suggest that the neurovascular unit plays a larger role in the neurobiological consequences of ELA in human females.

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