Association between changes in lipid indexes and early progression of kidney dysfunction in participants with normal estimated glomerular filtration rate: a prospective cohort study

Zhai, Qi; Dou, Jingtao; Wen, Jing; Wang, Meiping; Zuo, Yingting; Su, Xin; Zhang, Hongjie; Gaisano, Herbert Y.; Mu, Yiming; He, Yan

doi:10.1007/s12020-022-03012-z

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…Single-center cross-sectional studies showed that higher RC was independently associated with proteinuria, prevalence, and severity of CKD [ 12 , 13 , 17 ]. In addition, prospective cohort studies also found that an increase in RC was associated with the progression of renal impairment, suggesting that RC can be used as a monitoring indicator for the development of CKD [ 16 , 19 ]. Recent studies have indicated a significant association between elevated RC levels and CKD in populations with cardiovascular risk factors such as hypertension and diabetes [ 18 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Remnant cholesterol, preinflammatory state and chronic kidney disease: association and mediation analyses

Yuan,

Hu,

Zhang

et al. 2024

Renal Failure

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Section: Discussionmentioning

confidence: 99%

Remnant cholesterol, preinflammatory state and chronic kidney disease: association and mediation analyses

Yuan,

Hu,

Zhang

et al. 2024

Renal Failure

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“…CKD was defined as an estimated glomerular filtration rate (eGFR) of less than 60 ml/min·1.73 m 2 . The eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration ( 12 ). Body mass index (BMI) was calculated by dividing the weight by the square of height.…”

Section: Methodsmentioning

confidence: 99%

Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients

et al. 2023

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BackgroundRemnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hypertension.MethodsOur study is based on the Chinese H-type Hypertension Project, which is an observational registry study conducted in real-world settings. The outcome was CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min·1.73 m2. Multivariate logistic regression and smooth curve fitting were used to analyze the association between RC and CKD. Subgroup analyses were subsequently conducted to examine the effects of other variables.ResultsThe mean age of the 13,024 patients with hypertension at baseline was 63.8 ± 9.4 years, and 46.8% were male. A conspicuous linear positive association was observed between RC level and CKD (per SD increment; odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08–1.23). Compared with the lowest quartile group of RC, the risk of CKD was 53% higher (OR, 1.53; 95% CI, 1.26–1.86) in the highest quartile group. Furthermore, a stronger positive association between RC level and CKD was found among participants with a higher body mass index (BMI <24 vs. ≥24 kg/m2; P-interaction = 0.034) or current non-smokers (smoker vs. non-smoker; P-interaction = 0.024).ConclusionsAmong Chinese adults with hypertension, RC level was positively associated with CKD, particularly in those with a BMI of ≥24 kg/m2 and current non-smokers. These findings may help improve lipid management regimens in patients with hypertension.

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Remnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults

Yang,

Tang,

Yang

et al. 2024

Sci Rep

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We aimed to identify different trajectories of remnant cholesterol (RC) and investigate the association of RC trajectories with vascular endothelial function and atherosclerosis progression in a longitudinal cohort of the Chinese population. A total of 521 participants were included in the flow-mediated vasodilation (FMD) subcohort study, and 7775 participants were included in the brachial-ankle pulse wave velocity (baPWV) subcohort study. All participants had ≥ 3 medical examinations during the 10-year follow-up period. In the FMD subcohort study, three distinct RC trajectories were identified according to the RC range and changing pattern over time: “low” (57.58%), “moderate” (30.90%) and “high” (11.52%). The proportion of the three groups with vascular endothelial dysfunction (FMD < 7.0%) was 20.00%, 39.75% and 60.00% respectively. Taking the low group as a reference, participants in the moderate and high groups had over 1.88 and 2.94 times the odds of vascular endothelial dysfunction (P = 0.048). In the baPWV subcohort study, three distinct RC trajectories were also identified: “low” (54.29%), “moderate” (38.97%) and “high” (6.74%). The proportion of the three groups with atherosclerosis (baPWV > 1400 cm/s) was 38.79%, 51.26% and 59.01% respectively. Taking the low group as a reference, participants in the moderate and high groups had over 1.46 and 2.16 times the odds of atherosclerosis (P < 0.001). The findings indicated that distinct RC trajectories are significantly associated with vascular endothelial function and atherosclerosis. Regular monitoring to identify persistent increases in RC may be more helpful in identifying individuals with a high risk of cardiovascular disease.

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Association between changes in lipid indexes and early progression of kidney dysfunction in participants with normal estimated glomerular filtration rate: a prospective cohort study

Cited by 5 publications

References 37 publications

Remnant cholesterol, preinflammatory state and chronic kidney disease: association and mediation analyses

Remnant cholesterol, preinflammatory state and chronic kidney disease: association and mediation analyses

Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients

Remnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults

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