Association between cardiovascular risk factors and stage 1 hypertension defined by the 2017 ACC/AHA guidelines

Liu, Xing Zhen; Chen, Dong Shui; Di, Fu Ping; Cheng, Sheue-yann; Li, Hui Hua; Wang, Jun Min; Ji, Yi Xin

doi:10.1080/10641963.2020.1714639

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…This cross-sectional study was based on a database of adults who received routine health screening between January 2013 and July 2019 in China, which has been previously described [ 7 , 8 ]. The main exclusion criteria were DBP ≥ 90 mmHg and the use of statins and antihypertensive drugs.…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of the association between traditional and lipid-related obesity indicators and isolated systolic hypertension

Qian

Chen³

et al. 2022

BMC Cardiovasc Disord

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Background Obesity is a well-known modified risk factor for isolated systolic hypertension (ISH), but evidence is lacking regarding whether the combination of anthropometric and lipid indicators could strengthen their correlation with ISH. Therefore, we compared the association of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), visceral adiposity index (VAI), lipid accumulation product index (LAP), and cardiometabolic index (CMI) with ISH. Methods A total of 106,248 adults who received routine health screening and did not have diastolic blood pressure ≥ 90 mmHg were recruited in this cross-sectional study. The associations between these indicators and ISH were evaluated using multivariate regression. Results Each standard deviation (SD) increase in traditional obesity indicators (especially WHR and WHtR) had significantly higher multivariate-adjusted odds ratios (ORs) than each SD increase in lipid-related obesity indicators. In addition, multivariate-adjusted ORs for ISH in the third (vs. the first) tertile of traditional obesity indicators were also significantly higher than those of lipid-related indicators. Moreover, traditional obesity indicators exhibited a higher area under the ROC curve for discriminating ISH than lipid-related obesity indicators. Conclusions Traditional obesity indicators were more strongly associated with ISH than lipid-related obesity indicators among Chinese adults.

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Section: Methodsmentioning

confidence: 99%

Comparative analysis of the association between traditional and lipid-related obesity indicators and isolated systolic hypertension

Qian

Chen³

et al. 2022

BMC Cardiovasc Disord

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“…Cardiovascular diseases (CVDs) are one of the leading causes of mortality 1,2 . Most of the deaths are attributed to stroke, myocardial infarction, coronary artery diseases and atrial fibrillation 3 , in which hypertension and obesity are considered as major risk factors 4 . Although hypertension was identified in the late 1950s as a primary risk factor, it still represents a global public health challenge 1,2 .…”

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confidence: 99%

Blood pressure-lowering effects of a Bowman-Birk inhibitor and its derived peptides in normotensive and hypertensive rats

Freitas

Amaral

Álvares

et al. 2020

Sci Rep

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Bioactive plant peptides have received considerable interest as potential antihypertensive agents with potentially fewer side effects than antihypertensive drugs. Here, the blood pressure-lowering effects of the Bowman-Birk protease inhibitor, BTCI, and its derived peptides, PepChy and PepTry, were investigated using normotensive (Wistar-WR) and spontaneously hypertensive rats (SHR). BTCI inhibited the proteases trypsin and chymotrypsin, respectively, at 6 µM and 40 µM, a 10-fold greater inhibition than observed with PepTry (60 µM) and PepChy (400 µM). These molecules also inhibited angiotensin converting enzyme (ACE) with IC 50 values of 54.6 ± 2.9; 24.7 ± 1.1; and 24.4 ± 1.1 µM, respectively, occluding its catalytic site, as indicated by molecular docking simulation, mainly for PepChy and PepTry. Gavage administration of BTCI and the peptides promoted a decrease of systolic and diastolic blood pressure and an increase of renal and aortic vascular conductance. These effects were more expressive in SHR than in WR. Additionally, BTCI, PepChy and PepTry promoted coronary vasodilation and negative inotropic effects in isolated perfused hearts. The nitric oxide synthase inhibitor blunted the BTCI and PepChy, with no cardiac effects on PepTry. The findings of this study indicate a therapeutic potential of BTCI and its related peptides in the treatment of hypertension.

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“…Nonetheless, some of the studies limited the age of their study population to above 41 years, a cutoff that was not really representative of the entire population. In addition, subgroup analysis showed that stage 1 hypertension did not trigger a higher risk of CVD in participants aged above 60 years ( 19 ). Contrary to previously reported findings, the present study revealed that stage 1 hypertension participants aged ≥60 years were at greatly higher risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

The Association of Stage 1 Hypertension, Defined by the 2017 ACC/AHA Guidelines, With Cardiovascular Events Among Rural Women in Liaoning Province, China

Duan

Jiao

et al. 2021

Front. Cardiovasc. Med.

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Background: The recent American College of Cardiology/American Heart Association (ACC/AHA) guidelines redefined blood pressure levels 130-139/80-89 mmHg as stage 1 hypertension. However, the association of stage 1 hypertension with cardiovascular disease (CVD) and its age-specific differences among the rural women in Liaoning province remains unclear. It needs to be quantified in considering guideline adoption in China.Methods: In total, 19,374 women aged ≥35 years with complete data and no cardiovascular disease at baseline were followed in a rural community-based prospective cohort study of Liaoning province, China. Follow-up for the new cases of CVD was conducted from the end of the baseline survey to the end of the third follow-up survey (January 1, 2008–December 31, 2017). Adjusted Cox proportional hazards models were applied to estimate the Hazard Ratios (HR) and 95% Confidence Intervals (CI) with the normal blood pressure as a reference.Results: During the median follow-up period of 12.5 years, 1,419 subjects suffered all-cause death, 748 developed CVD, 1,224 participants suffered stroke and 241 had Myocardial Infarction (MI). Compared with normal BP, Stage 1 hypertension had a HR (95% CI) of 1.694 (1.202–2.387) in CVD mortality, 1.575 (1.244–1.994) in the incidence of stroke. The results obtained that the risk of CVD mortality and incidence of stroke was significantly associated with stage 1 hypertension in rural women aged ≥45 years after adjusting for other potential factors. However, in participants aged 35–44 years, stage 1 hypertension was not associated with an increased risk of cardiovascular disease.Conclusions: The newly defined stage 1 hypertension is associated with an increased risk of CVD mortality and also incidence of stroke in the rural women aged ≥45 years population of Liaoning province. This study can be a good reference for health policy makers and clinicians workers to make evidence-based decisions toward lowering burden of cardiovascular disease more efficient, timely measures on prevention and control of stage 1 hypertension in China.

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Association between cardiovascular risk factors and stage 1 hypertension defined by the 2017 ACC/AHA guidelines

Cited by 3 publications

References 34 publications

Comparative analysis of the association between traditional and lipid-related obesity indicators and isolated systolic hypertension

Comparative analysis of the association between traditional and lipid-related obesity indicators and isolated systolic hypertension

Blood pressure-lowering effects of a Bowman-Birk inhibitor and its derived peptides in normotensive and hypertensive rats

The Association of Stage 1 Hypertension, Defined by the 2017 ACC/AHA Guidelines, With Cardiovascular Events Among Rural Women in Liaoning Province, China

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