Comparative analysis of the association between traditional and lipid-related obesity indicators and isolated systolic hypertension

Abstract

Background Obesity is a well-known modified risk factor for isolated systolic hypertension (ISH), but evidence is lacking regarding whether the combination of anthropometric and lipid indicators could strengthen their correlation with ISH. Therefore, we compared the association of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), visceral adiposity index (VAI), lipid accumulation product index (LAP), and cardiometabolic index (CMI) with ISH. Methods A total of 106,248 adults who received routine health screening and did not have diastolic blood pressure ≥ 90 mmHg were recruited in this cross-sectional study. The associations between these indicators and ISH were evaluated using multivariate regression. Results Each standard deviation (SD) increase in traditional obesity indicators (especially WHR and WHtR) had significantly higher multivariate-adjusted odds ratios (ORs) than each SD increase in lipid-related obesity indicators. In addition, multivariate-adjusted ORs for ISH in the third (vs. the first) tertile of traditional obesity indicators were also significantly higher than those of lipid-related indicators. Moreover, traditional obesity indicators exhibited a higher area under the ROC curve for discriminating ISH than lipid-related obesity indicators. Conclusions Traditional obesity indicators were more strongly associated with ISH than lipid-related obesity indicators among Chinese adults.

Isolated systolic hypertension and its associated risk factors in Iranian middle age and older population: a population-based study

“…According to the results of this study, other factors significantly associated with the prevalence of ISH were diabetes and WHR which is consistent with the previous studies [ 31 , 39 , 40 ]. The prevalence of hypertension in diabetes patients is most common in comparison to the general population.…”

Waist-to-height ratio is a better predictor of hypertension in women during recovery from anesthesia compared to BMI, waist-to-hip ratio, and waist circumference

“…Patients with BMI ≥28 (kg/m2), WC > 85 cm, WHR ≥0.82, and WHtR ≥0.5 had a significantly higher risk of increased BP. After adjusting for general data such as age, smoking, drinking, and surgery-related variables, we found that the body fat indices correlated with the BP during recovery from general anesthesia but WHtR was superior to the others (slightly more than WHR), in accordance with the correlation of these obesity indices with BP found in studies outside the anesthesia clinical setting [ [26] , [27] , [28] ]. Obesity impacts the pharmacokinetics and pharmacodynamics of anesthetic drugs [ 29 ], and since different anthropometric measures represent different patterns of fat deposition, increased fat mass increases the volume of distribution of lipophilic drugs and increases susceptibility to drug sensitivity [ 30 ].…”

Lipid accumulation product and visceral adiposity index for incidence of cardiovascular diseases and mortality; results from 13 years follow‐up in Isfahan cohort study

“…14 Nevertheless, several articles claimed there is no superiority in applying these novel anthropo-metabolic indices over the traditional ones, including BMI and WC, for predicting HTN. 40,41 Higher VAI and LAP scores represent increased visceral fat, including the perirenal space and renal sinuses. The fat can compress the kidneys, increase intrarenal pressure, and reduce medullary blood flow, leading to the renin-angiotensin-aldosterone system's (RAAS) activation, sodium reabsorption, secretion, and ultimately HTN.…”

“… 14 Nevertheless, several articles claimed there is no superiority in applying these novel anthropo‐metabolic indices over the traditional ones, including BMI and WC, for predicting HTN. 40 , 41 …”