Association between CAPN10 UCSNP-43 gene polymorphism and polycystic ovary syndrome in Chilean women

Association of calpain 10 gene UCSNP-43 polymorphism (rs3792267) with polycystic ovarian syndrome

“…In the present study, the AA genotype showed elevated values in body mass index (BMI), waist to hip ratio (WHR), homeostatic model assessment model score (HOMA), triglyceride levels and very low density lipoproteins levels, and decreased levels of high density lipoprotein levels, compared to AG and GG genotypes of PCOS and controls. Contrary to our study Marquez et al 27 suggested that the presence of uncommon (A) allele for UCSNP43 was significantly associated to PCOS.…”

Association between a nucleotide polymorphism in the calpain 10 gene and carbohydrate metabolism disturbances in patients with polycystic ovary syndrome

“…In PcoS and type 2 diabetes, there are many common etiological factors [13]. the occurrence of the relationship (p = 0.027) between SNP43 polymorphism of the calpain 10 gene and the risk of PcoS development in chilean women has been reported [14]. Similar results were obtained by other researches in a group of women in Brazil [15].…”

Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome

“…Although Wiltgen et al [24] did not find a direct association between UCSNP43, UCSNP19 and UCSNP63 and susceptibility to PCOS in Brazilian patients, they found an association between higher prevalence of the UCSNP43 polymorphic allele of the CAPN10 gene and metabolic syndrome in PCOS women. Márquez et al [25] suggested that the presence of uncommon (A) allele for UCSNP43 was significantly associated to PCOS. Similarly, we found that the percentages of "A" allele (19% for cases vs. 18% for controls) were quite less than those of "G" allele (81% for cases vs. 82% for controls).…”

“…It was identified as a T2DM susceptibility locus by Horikawa et al [22] and has been shown to be related to proinsulin processing, insulin secretion and insulin resistance [23]. Potential associations between five different polymorphisms and PCOS have been investigated [5,[24][25][26][27]. Insulin receptor gene (INSR) comprises 22 exons spanning 120 kilobases on chromosome 19p13.3-p13.2 [28].…”