Association between calcium channel blockers and gingival hyperplasia

Kaur, Gaganpreet; Verhamme, Katia; Dieleman, Jeanne P.; Vanrolleghem, Ann M.; Soest, Eva M. van; Stricker, Bruno H. Ch.; Sturkenboom, Miriam

doi:10.1111/j.1600-051x.2010.01574.x

Cited by 31 publications

(31 citation statements)

References 25 publications

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“…[3334] Synergistic effects have been reported when cyclosporin is administered concurrently with calcium channel blockers of dihydropyridine derivatives. [35]…”

Section: Drugs Which Cause Gingival Overgrowthmentioning

confidence: 99%

Drug-induced gingival overgrowth: The nemesis of gingiva unravelled

Bharti¹,

Bansal²

2013

J Indian Soc Periodontol

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Drug-induced gingival overgrowth or enlargement manifests as abnormal growth of the gingiva due to an adverse drug reaction (ADR) in patients treated with anticonvulsants, immunosuppressants, and calcium channel blockers. As gingival enlargement develops, it affects the normal oral hygiene practice and may interfere with masticatory functions. It gradually becomes a source of pain and the condition often leads to disfiguration. Within the group of patients that develop this unwanted effect, there appears to be variability in the extent and severity of the gingival changes. It would seem pertinent to identify and explore possible risk factors and relating them with the treatment plan. This article throws light on respective drugs and their association with gingival overgrowth and approaches to treatment based on current knowledge and investigative observations.

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“…[3334] Synergistic effects have been reported when cyclosporin is administered concurrently with calcium channel blockers of dihydropyridine derivatives. [35]…”

Section: Drugs Which Cause Gingival Overgrowthmentioning

confidence: 99%

Drug-induced gingival overgrowth: The nemesis of gingiva unravelled

Bharti¹,

Bansal²

2013

J Indian Soc Periodontol

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“…KKB ve CsA'nın jinjival hiperplaziye neden olduğu bilinmektedir. 53,54 Her ne kadar jinjival hiperplazi tanısı olan iki olguda da ilaç etyolojik faktör olarak görülse de, hasta sayısının az olması nedeniyle bu ilişki istatistiksel düzeyde anlamlı olarak sonuçlan-madı. Çalışmamızda ayrıca, araştırdığımız dermatolojik hastalıklar ve OML ilişkisinde istatistiksel düzeyde yalnızca akne grubu hastalıklar ile keilit gelişimi arasında anlamlılık tespit edildi, bu bulgunun da izotretinoin tedavisi alanlarda görülen ilaca bağlı keilit nedeniyle ortaya çıktığı düşüncesinde-yiz.…”

Section: Discussionunclassified

Investigation of Oral Mucosal Lesions in Patients Attending Dermatology Outpatient Clinic: A Study of 1670 Cases

Yorulmaz¹,

Doğan²,

Kılıç³

et al. 2016

Turkiye Klinikleri J Med Sci

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73Dermatoloji Polikliniğine Başvuran Hastalarda Oral Mukoza Hastalıklarının Araştırılması: 1670 Hasta Kapsayan Bir Çalışma Ö ÖZ ZE ET T A Am ma aç ç: : Birçok dermatolojik hastalığa oral mukozal bulgular eşlik eder. Oral mukozal lezyonlar (OML) bazen tanımlanamamış bir hastalığa doğru tanı koymada yol gösteren tek ipucu olabilir. Türkiye'de OML üzerine yürütülmüş oldukça az sayıda çalışma mevcuttur. Biz de bu çalışma ile genel Türk toplumunda OML'nin prevalansını ve bunu etkileyen faktörleri ortaya koymayı hedefledik. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bin altı yüz yetmiş hasta (950 kadın, 720 erkek) bu çalışma kapsamında incelendi. Hastaların yaş, eşlik eden hastalıklar, ilaç hikayesi, sigara ve alkol kullanımı, dolgu, kaplama ve protez gibi dental muayene bulguları, dermatolojik hastalıkları ve mevcutsa OML'ı kaydedildi ve ayrıntılı istatistiksel analizler yapıldı. B Bu ul lg gu ul la ar r: : OML'nin genel prevalansı %37,8 idi (kadın=%34,8, erkek=%41,6). Paslı dil en sık karşılaşılan OML idi (%6,7), bunu fissüre dil (%4,4) ve Fordyce granülleri (%3,9) izlemekteydi. Paslı dil erkekler, orta yaşlı erişkinler (35-54 yıl) ve 20-39 sigara/gün sıklığında sigara içenlerde istatistiksel olarak anlamlı oranda daha fazla tespit edildi. Alkol kullanımı ile OML görülme sıklığı arasında istatistiksel olarak anlamlı kabul edilebilecek herhangi bir ilişki saptanmadı. Venöz göllenme, protez stomatiti ve glossit ileri yaş (65 yıl ve üzeri) ile istatistiksel anlamda ilişkili bulundu. Bu çalışma grubunda kandidiyazis ve Behçet hastalığı erkeklerde, glossit ise kadınlarda istatistiksel olarak anlamlı oranda daha yüksek tespit edildi. S So on nu uç ç: : Gü-nümüze kadar farklı ülkelerde ve farklı bölgelerde OML üzerine çok sayıda çalışma yapılmıştır. Ancak bunların az bir kısmı dermatologlar tarafından yürütülmüştür. Bu ve benzer çalışmaların OML'in sınıflandırma ve yönetiminde faydalı bilgiler sağlayacağı kanaatindeyiz.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Oral belirtiler; dermatoloji; prevalans A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Many dermatological diseases have oral mucosal findings. Oral mucosal lesions (OML) sometimes may be the only clue to make a correct diagnosis about an obscure disease. There is only a limited number of studies about OML that had been conducted in Turkey. In this study, we aimed to determine the prevalence and factors affecting the occurence of OML in the general population of Turkey. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total number of 1.670 patients (950 females, 720 males) were enrolled in this study. Detailed information about patients' characteristics such as age, accompanying diseases, drug history, smoking habits, alcohol consumption, dental status such as dental filling, crown and prosthesis, dermatological diseases and, if present, OML were recorded and detailed statistical analyses were done. R Re es su ul lt ts s: : The overall prevalence of OML was 37.8% (females=34.8%, males=41.6%). Coated tongue was the mos...

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“…Some studies showed an association between the use of CCBs and gingival hyperplasia (29, 30). Two main inflammatory and non-inflammatory pathways have been already suggested.…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Potential of Topical Amlodipine in Full Thickness Wound of Rabbit

Hemmati

Forushani

Asgari

2014

Jundishapur J Nat Pharm Prod

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Background: Wound healing is a complicated and integrated process. Researches have indicated the wound healing effects of calcium channel blockers in animal models in recent years. Objectives: The aim of this study was to evaluate the wound-healing activity of amlodipine as a calcium channel blocker and combination of amlodipine with phenytoin on excisional cutaneous wound models in rabbit. Materials and Methods: Animals were divided into 5 groups (n = 5). The control group was treated topically with eucerin. The untreated control group received no healing agent. The reference standard group was treated with phenytoin1%. A treatment group was treated with amlodipine 1%. The last group was treated with combination of amlodipine1% and phenytoin 1%. Results: Results indicated significant difference between days needed for complete healing in both of the treatment groups. Wound closure was completed on 13th day and 9th day in amlodipine and combination groups respectively. Conclusions: In conclusion, calcium channel blockers can be used to enhance wound healing, especially if this treatment becomes with phenytoin. Further studies are needed to find out the mechanism of this healing effect.

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Association between calcium channel blockers and gingival hyperplasia

Abstract: This study shows that the risk of gingival hyperplasia is twofold higher in current users of CCBs than in users of RAS drugs. The association was dose dependent and the highest for dihydropyridines or benzothiazepine derivates.

Cited by 31 publications

References 25 publications

Drug-induced gingival overgrowth: The nemesis of gingiva unravelled

Drug-induced gingival overgrowth: The nemesis of gingiva unravelled

Investigation of Oral Mucosal Lesions in Patients Attending Dermatology Outpatient Clinic: A Study of 1670 Cases

Wound Healing Potential of Topical Amlodipine in Full Thickness Wound of Rabbit

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