Association between Bovine Collagen Dermal Implants and a Dermatomyositis or a Polymyositis-like Syndrome

Abstract

Because these data suggest that an immunologic response to bovine type I or type III collagen or both caused this dermatomyositis or polymyositis-like syndrome, the risks versus benefits for the cosmetic use of collagen implants should be reassessed.

Still's-like disease, breast prosthesis, and collagen implants

“…Between 1 and 9.8% of the negative patients may, however, show evidence of hypersensitivity reactions after collagen injection, encompassing edema, erythema, skin induration, and local pruritus [13]. Biopsy specimens from injection sites usually show typical foreignbody granulomas [13,14]. In addition, systemic adverse reactions have also been described [13,15,16,17,18].…”

“…Positive tests arise in approximately 2.5 to 4% of persons and result in an implant material contraindication [13]. Between 1 and 9.8% of the negative patients may, however, show evidence of hypersensitivity reactions after collagen injection, encompassing edema, erythema, skin induration, and local pruritus [13]. Biopsy specimens from injection sites usually show typical foreignbody granulomas [13,14].…”

“…Before inserting implants, hypersensitivity testing is usually carried out by intradermal injection of bovine collagen. Positive tests arise in approximately 2.5 to 4% of persons and result in an implant material contraindication [13]. Between 1 and 9.8% of the negative patients may, however, show evidence of hypersensitivity reactions after collagen injection, encompassing edema, erythema, skin induration, and local pruritus [13].…”

Immunologic Aspects of Bovine Injectable Collagen in Humans

“…Cukier et al [29] have reported that the incidence of DM or PM was statistically increased among collagen-treated patients (8 patients with DM and 1 patient with PM among approximately 345,000 patients receiving injectable bovine collagen from July 1980 to June 1988) compared with the expected incidence in the general population.…”

Tissue-engineered therapies for the treatment of urinary incontinence and vesicoureteral reflux

“…Although it is not prone to migration or granuloma formation, GAX-collagen fails to conserve its volume over time, resulting in the need for periodic retreatment [12]. In addition, its administration has been implicated in acute hypersensitivity reactions and in the sporadic development of connective-tissue diseases posttherapy [10].…”