Tissue-engineered therapies for the treatment of urinary incontinence and vesicoureteral reflux

Kershen, Richard T.; Fefer, S; Atala, Anthony

doi:10.1007/pl00007072

Cited by 34 publications

(16 citation statements)

References 16 publications

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“…These endoscopic procedures are attractive because they are minimally invasive and it is anticipated that they will decrease patient discomfort, surgery extent, and operating time. [1][2][3][4][5][6] Several injectable bulking agents, such as polytetrafluoroethylene (PTFE) paste, 7,8 collagen gel, 9 -12 liquid or particulated silicone, [13][14][15][16] polymethylmethacrylate (PMMA) microspheres, [17][18][19] and autologous fat, 20,21 have been developed and applied in the injection therapies. However, concerns regarding the side effects of these materials have limited general acceptance of their usage.…”

Section: Introductionmentioning

confidence: 99%

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

et al. 2006

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The injection of bulking substances has been proposed as a new therapy to treat urinary incontinence and vesicoureteral reflux. Our previous study demonstrated that poly(lacticco-glycolic acid) (PLGA) microspheres have the potential to serve as a bulking agent for urological injection therapies. Hybrid tissues exhibiting a bulking effect were formed in vivo by PLGA microsphere injection, but long-term volume stability was not proven. In this study, we hypothesized that the biodegradation rate of the bulking substance (polymer microspheres) would affect the duration of volume conservation of the induced hybrid tissue. To test this hypothesis, rapidly degrading 75:25 PLGA microspheres and slowly degrading poly(L-lactic acid) (PLLA) microspheres were used as injectable bulking agents for the injection therapy. In vitro degradation tests showed that the mass losses of PLLA and PLGA were 16 and 96% of the initial masses, respectively, at 30 weeks. PLLA and PLGA microspheres were injected into the subcutaneous dorsum of mice. Both types of microspheres were easily injectable through 24-gauge needles. Histological examinations at various time points indicated that host cells from the surrounding tissues migrated to the spaces between both types of injected microspheres and formed new hybrid tissue structures. Lymphocyte migration was noted around the implanted PLGA and PLLA microspheres, but the inflammatory reaction diminished with time. Importantly, the volume of the PLLA hybrid tissues slowly decreased to 52% of the initial volume at 12 months and maintained that volume until 18 months, whereas the volume of the PLGA hybrid tissues rapidly decreased to 22% at 6 months, and the PLGA hybrid tissues disappeared at 11 months. These results show that the biodegradation rate of the bulking substance may be useful for controlling the duration of volume conservation of the induced hybrid tissue.

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Section: Introductionmentioning

confidence: 99%

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

et al. 2006

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“…Por otra parte, ensayos clínicos en fase I se llevaron a cabo para la corrección de la incontinencia urinaria por deficiencia intrínseca del esfínter mediante la inyección endoscópica de condrocitos autólogos cultivados en mujeres 74 . Los resultados fueron presentados en el International Society Meeting en Denver, donde se habían tratado un total de 32 mujeres con un porcentaje de éxitos del 84% a los 6 meses de seguimiento.…”

Section: Reflujo Vesico-ureteralunclassified

Estado actual de la ingeniería de tejidos en urología: Revisión de la literatura

Rodríguez

Peña²,

Edreira

et al. 2004

Actas Urol Esp

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RESUMEN ESTADO ACTUAL DE LA INGENIERÍA DE TEJIDOS EN UROLOGÍA.REVISIÓN DE LA LITERATURA En la década de los 80 surge un nuevo campo de la medicina que aplica los principios del cultivo celular a polímeros sintéticos biodegradables de soporte con el fin de crear sustitutos biológicos autólogos que puedan mejorar, mantener o restaurar la función de órganos o tejidos dañados.La Ingeniería Tisular constituye una nueva disciplina en plena fase de desarrollo, especialmente en USA, con múltiples potenciales aplicaciones en las diferentes especialidades médicas.Nuestra especialidad no puede permanecer ajena al interés y esperanzador futuro suscitado por esta nueva ciencia.En el presente trabajo realizamos una amplia revisión bibliográfica en Medline con objeto de conocer los antecedentes, estado actual y las posibles aplicaciones futuras de la Ingeniería de Tejidos en Urología.PALABRAS CLAVE: Cultivo in vitro. Cultivo celular. Urotelio. Ingeniería tisular. ABSTRACT CURRENT STATE OF THE TISSUE ENGINEERING IN UROLOGY.REVISION OF THE LITERATURE In the eighties a new field of the medicine appears wich applies the principles of cellular cultivation to synthetic biodegradable polymers scaffolds with the purpose of creating autologous biological substitutes that could improve, maintain or restore the function of organs or damaged tissues.The Tissue Engineering constitutes a new discipline in full phase of development especially in USA, with multiple potential applications in several medical specialities.Our speciality can't remain indifferent to interest and encouraging future originated by this new science.In this work we have made a wide bibliographical revision in the Medline to know the antecedents, current state and the possible future applications of Tissue Engineering in Urology.

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“…Refinements in the technique and the delivery vehicle for electrical stimulation may offer an even less in-vasive method of neuromodulation. Finally, ongoing research in biotechnology and tissue engineering may produce a functional, stable, compatible tissue substitute suitable for bladder augmentation that is produced entirely in the laboratory, thereby precluding the need for bowel interposition in the urinary tract and its attendant morbidity [65][66][67][68][69][70] .…”

Section: Other Therapiesmentioning

confidence: 99%

Evaluation and treatment of the overactive bladder

Gomes¹,

Trigo-Rocha²,

Arap³

et al. 2002

Rev. Hosp. Clin.

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The overactive bladder is characterized by symptoms of frequency, urgency, and urge incontinence, substantially affecting the quality of life of millions of people throughout the world. The symptoms are associated with significant social, psychological, occupational, domestic, physical, and sexual problems. Despite the considerable impact of this condition on quality of life, sufferers are often unwilling to discuss their problem with family members or health care professionals. This situation is unfortunate, for much can be done to alleviate the symptoms of this distressing condition. It is therefore of utmost importance that medical education about symptoms of the overactive bladder and other related problems be improved to help health care professionals identify and treat patients who will benefit from therapy. This article reviews current thinking regarding definition, epidemiology, quality of life effects, evaluation, and management of the overactive bladder.

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Tissue-engineered therapies for the treatment of urinary incontinence and vesicoureteral reflux

Cited by 34 publications

References 16 publications

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

Estado actual de la ingeniería de tejidos en urología: Revisión de la literatura

Evaluation and treatment of the overactive bladder

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