Association between Blood Level of Plasma Oxytocin and Novelty Seeking among Methadone-Maintained Heroin Users

Lin, Shio Jean; Lee, Lan Ting; Tsai, Hsin Chun; Chen, Kao Chin; Chen, Wei Tseng; Lee, I. Hui; Lu, Ru Band; Chen, Po See; Yang, Yen Kuang

doi:10.1159/000371637

Cited by 19 publications

(9 citation statements)

References 37 publications

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“…Animal studies have indicated that novelty-seeking tendency is related to addiction behaviors [33], and this phenomenon has also been confirmed in human studies [26, 34]. In our previous study, an association between oxytocin and novelty-seeking was identified [21]. We speculated that novelty-seeking and oxytocin might be 2 distinct factors that affect addiction; the former could be a stable temperament or trait, and the plasma level of oxytocin might vary due to physiological state changes.…”

Section: Introductionmentioning

confidence: 65%

“…Although it is as yet unclear whether oxytocin and dopamine have a direct association, accumulating evidence has suggested that oxytocin may have a positive effect on treatment for alcohol use disorders and other problematic substance abuse [16, 17]. In addition, there could exist an association between dopamine and novelty-seeking tendency [18], which could be an important issue related to addiction and oxytocin [19-21]. …”

Section: Introductionmentioning

confidence: 99%

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The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

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Background: Animal studies have demonstrated that oxytocin can influence addiction behaviors and might interact with the dopaminergic system, which is a key component of addiction behaviors. However, related evidence from clinical studies is scarce. The aim of our study was to explore the relationship between plasma oxytocin level and heroin craving among patients receiving methadone maintenance treatment, and to ascertain whether this relationship is moderated by novelty-seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan. Seventy-seven patients with heroin addiction were enrolled. Plasma oxytocin was measured using an ELISA kit. Craving was assessed using an established instrument, the Chinese Craving Scale. Results: A significant negative association was found between the plasma oxytocin level and craving score, which remained robust after controlling the effects of social support and low-density lipoprotein cholesterol. An interaction between oxytocin and novelty-seeking indicated that this relationship was stronger among patients with a lower level of novelty-seeking. Conclusion: This finding may be taken into account in future studies and may provide a basis for the development of potential treatment for addiction. The effect of oxytocin for the treatment of opioid dependence might be modulated by some psychological factors.

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Section: Introductionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

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“…The administration of carbetocin, an oxytocin receptor agonist, prevents reinstatement of conditioned reinforcing effects of morphine ( 16 ) and alcohol ( 14 ). Further evidence supporting the role of oxytocin in the involvement of addiction is that a negative association of plasma oxytocin levels with novelty-seeking, one of the indicators of addiction, was observed in heroin users ( 17 ).…”

Section: Introductionmentioning

confidence: 97%

Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence

et al. 2018

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Background: Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a common drug of abuse worldwide. Existing evidence suggest a disruption of oxytocin system involves in the development of addiction. In this study, we aimed to investigate the role of oxytocin in ketamine addiction by measuring the blood oxytocin levels in ketamine-dependent (KD) patients.Methods: Sixty-five KD patients and 65 controls were enrolled. Fasting plasma levels of oxytocin were determined at baseline and 1 and 2 weeks after ketamine withdrawal. Ketamine use variables, Beck Depression Inventory, Beck Anxiety Inventory (BAI), Visual Analog Scale for craving, and Childhood Trauma Questionnaire-short form were assessed in KD patients.Results: KD patients had significantly lower levels of oxytocin at baseline compared to controls (5.89 ± 2.13 vs. 9.53 ± 4.17 ng/mL, P < 0.001). Oxytocin levels increased after one (6.74 ± 2.63, P < 0.002) and 2 weeks (6.89 ± 2.69, P = 0.01) of withdrawal in KD patient despite the levels were still lower than controls (P = 0.001 and 0.002, respectively). The clinical variables did not correlate with baseline oxytocin levels except BAI scores, which showed a negative correlation with the levels (r = −0.263; P = 0.039).Conclusion: We found a distinctively reduced oxytocin level in KD patients and the level did not normalize after early abstinence. Lower oxytocin might be associated with anxious phenotype of ketamine dependence. These results suggest that oxytocin system dysregulated following chronic ketamine abuse and might provide insight in evaluating the potential therapeutic use of oxytocin for treating ketamine dependence.

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“…NS has been linked to several neuropsychiatric disorders, including drug addiction (Bardo et al, 1996 ; Lin et al, 2015 ; Vanhille et al, 2015 ), alcohol and tobacco abuse (Palmer et al, 2013 ), pathological gambling (Kim and Grant, 2001 ), eating disorders (Krug et al, 2009 ), post-traumatic stress disorder (PTSD) (Jakšić et al, 2012 ), and depression (Duclot and Kabbaj, 2013 ), yet the association with GM volume of the pulvinar remains to be investigated.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Gray Matter Volume of a Region in the Thalamic Pulvinar Is Specifically Associated with Novelty Seeking

2018

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Personality reflects the set of psychological traits and mechanisms characteristic for an individual. Geno-neuro-biologically inspired personality accounts have proposed a set of temperaments and characters that jointly compose personality profiles. The present study addresses the link between neurobiology and personality and investigates the association between temperament traits and regional gray matter volume. Furthermore, the specificity of these associations as well as the underlying components that drive the association are addressed. One hundred and four participants completed the Temperament and Character Inventory (TCI) and underwent structural magnetic resonance brain imaging. The participants included premanifest carriers of Huntington's disease, as this population is associated with temperament-related neuropsychiatric symptoms. Whole brain voxel-based multiple regression analyses on gray matter volume revealed a significant specific positive correlation between a region in the left thalamic pulvinar and novelty seeking score, controlled for the other traits (Pheight < 0.05, FWE-corrected). No significant associations were observed for the other temperament traits. Region of interest analyses showed that this association is driven by the subscale NS2: impulsiveness. The results increase the knowledge of the structural neurobiology of personality and indicate that individual differences in novelty seeking reflect the structural differences observed in the brain in an area that is widely and densely connected, which is in line with the typically domain-general behavioral influence of personality traits on a wide range of affective, perceptual, mnemotic, executive, and other cognitive functions.

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Association between Blood Level of Plasma Oxytocin and Novelty Seeking among Methadone-Maintained Heroin Users

Cited by 19 publications

References 37 publications

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence

Gray Matter Volume of a Region in the Thalamic Pulvinar Is Specifically Associated with Novelty Seeking

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