Gray Matter Volume of a Region in the Thalamic Pulvinar Is Specifically Associated with Novelty Seeking

Stam, Daphne; Huang, Yun‐An; Stock, Jan Van den

doi:10.3389/fpsyg.2018.00203

Cited by 6 publications

(6 citation statements)

References 58 publications

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“…Also, a separate study of a similar sample size to our present study (56 subjects) but with much lower mean NS score (10.4 ± 3.5), reports a posi�ve correla�on between NS with the le� middle frontal gyrus volume irrespec�ve to gender (Iidaka et al, 2006). A third study with similar NS scores as this one (17.9 ± 6.167) reports a posi�ve associa�on between NS and the le� thalamic pulvinar regions (Stam et al, 2018) but the sample size was confounded by inclusion of first degree rela�ves of pa�ents Hun�ngton disease and an uneven balance of male and female par�cipants. It is also worth no�ng that in the present study, our par�cipant exclusion criteria included drug usage, tobacco smoking and excessive alcohol consump�on, all factors that might increase novelty-seeking (Addicot et al, 2014;Wingo et al, 2016).…”

Section: Main Findingssupporting

confidence: 74%

Regional brain structure at the intersection of novelty-seeking trait and anxiety

Tertikas,

Campbell-Meiklejohn,

Critchley

2023

Preprint

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The relationship between novelty-seeking and anxiety is complex. Individuals with a tendency for seeking new experiences (novelty-seeking bias) often navigate a delicate balance between their inherent curiosity and apprehension derived from anxiety. In this study, we investigated brain substrates mediating the relationship between novelty-seeking and anxiety by testing for differences in the grey matter (GM) structure. For this purpose, we applied voxel-based (VBM) and source-based morphometry (SBM) to imaging data from 50 healthy participants, looking, for the first time, at the relationship between regional GM volume and novelty-seeking, anxiety, and their interaction. On its own novelty-seeking bias (as quantified using the Tridimensional Personality Questionnaire) did not correlate with regional GM structure in both analyses. Trait anxiety (quantified using the State-Trait Anxiety Inventory (STAI)) correlated with increased subcallosal gyrus volume in the VBM analysis and was negatively associated with 2 components identified in the SBM analysis which mainly included temporal and frontal regions (i.e., left inferior temporal gyrus, inferior frontal gyrus, middle temporal gyrus, left middle frontal gyrus). Interaction between novelty-seeking score and anxiety score, was expressed in GM volume within the left inferior frontal gyrus (LIFG) in the VMB analysis. There was no suprathreshold interaction with the components identified using SBM. Together, this study provides new insight into the relationship between reward-related decision-making and anxiety. Within the left inferior frontal gyrus, GM volume reflected the interaction of novelty-seeking and anxiety, extending previous research that links lower left inferior frontal gyral volume to reduced impulsivity with increased harm avoidance and anxiety. Our findings suggest this as a possible candidate region for patient stratification and target for intervention in anxiety.

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Section: Main Findingssupporting

confidence: 74%

Regional brain structure at the intersection of novelty-seeking trait and anxiety

Tertikas,

Campbell-Meiklejohn,

Critchley

2023

Preprint

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“…13,65 A recent study including premanifest HD patients found novelty seeking, a measure of impulsivity, was correlated with structural differences in the left thalamic pulvinar. 66 Notably, work in PD has associated different dimensions of impulsivity with specific altered network connectivity patterns on diffusion imaging, which again correspond to regions implicated in apathy and crucial for normal goal-directed behavior. 67 Such characterization of impulsivity dimensions and their neural correlates remains to be investigated in people with HD.…”

Section: Neural Correlates Of Impulsivity and Apathy In Hd Overlapmentioning

confidence: 98%

“…Failed response inhibition in premanifest HD patients as well as disinhibition and pathological impulses in HD are associated with altered activation in very similar brain regions 13,65 . A recent study including premanifest HD patients found novelty seeking, a measure of impulsivity, was correlated with structural differences in the left thalamic pulvinar 66 . Notably, work in PD has associated different dimensions of impulsivity with specific altered network connectivity patterns on diffusion imaging, which again correspond to regions implicated in apathy and crucial for normal goal‐directed behavior 67 .…”

Section: Neural Correlates Of Impulsivity and Apathy In Hd Overlapmentioning

confidence: 99%

Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease

2022

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A caregiver's all‐too‐familiar narrative ‐ “He doesn't think through what he does, but mostly he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co‐occur in Huntington's disease (HD). HD is a neurodegenerative disease with manifestations bridging clinical neurology and psychiatry. In addition to movement and cognitive symptoms, neurobehavioral disturbances, particularly apathy and impulsivity, are prevalent features of HD, occurring early in the disease course, often worsening with disease progression, and substantially reducing quality of life. Treatments remain limited, in part because of limited mechanistic understanding of these behavioral disturbances. However, emerging work within the field of decision‐making neuroscience and beyond points to common neurobiological mechanisms underpinning these seemingly disparate problems. These insights bridge the gap between underlying disease pathology and clinical phenotype, offering new treatment strategies, novel behavioral and physiological biomarkers of HD, and deeper understanding of human behavior. In this review, we apply the neurobiological framework of cost‐benefit decision making to the problems of apathy and impulsivity in HD. Through this decision‐making lens, we develop a mechanistic model that elucidates the occurrence of these behavioral disturbances and points to potential treatment strategies and crucial research priorities. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.

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“…Several studies have investigated the associations between temperaments and regional GMv (Iidaka et al, 2006; Gardini et al, 2009; Picerni et al, 2013; Laricchiuta et al, 2014; Stam et al, 2018). However, sex is a variable that is typically statistically controlled for and little is known about its effect on temperament-brain associations.…”

Section: Introductionmentioning

confidence: 99%

Non-overlapping and Inverse Associations Between the Sexes in Structural Brain-Trait Associations

2019

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Personality reflects the set of psychological traits and mechanisms characteristic for an individual. The brain-trait association between personality and gray matter volume (GMv) has been well studied. However, a recent study has shown that brain structure-personality relationships are highly dependent on sex. In addition, the present study investigates the role of sex on the association between temperaments and regional GMv. Sixty-six participants (33 male) completed the Temperament and Character Inventory (TCI) and underwent structural magnetic resonance brain imaging. Mann-Whitney U tests showed a significant higher score on Novelty Seeking (NS) and Reward Dependence (RD) for females, but no significant group effects were found for Harm Avoidance (HA) and Persistence (P) score. Full factor model analyses were performed to investigate sex-temperament interaction effects on GMv. This revealed increased GMv for females in the superior temporal gyrus when linked to NS, middle temporal gyrus for HA, and the insula for RD. Males displayed increased GMv compared to females relating to P in the posterior cingulate gyrus, the medial superior frontal gyrus, and the middle cingulate gyrus, compared to females. Multiple regression analysis showed clear differences between the brain regions that correlate with female subjects and the brain correlates that correlate with male subjects. No overlap was observed between sex-specific brain-trait associations. These results increase the knowledge of the role of sex on the structural neurobiology of personality and indicate that sex differences reflect structural differences observed in the normal brain. Furthermore, sex hormones seem an important underlying factor for the found sex differences in brain-trait associations. The present study indicates an important role for sex in these brain structure-personality relationships, and implies that sex should not just be added as a covariate of no interest.

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Gray Matter Volume of a Region in the Thalamic Pulvinar Is Specifically Associated with Novelty Seeking

Cited by 6 publications

References 58 publications

Regional brain structure at the intersection of novelty-seeking trait and anxiety

Regional brain structure at the intersection of novelty-seeking trait and anxiety

Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease

Non-overlapping and Inverse Associations Between the Sexes in Structural Brain-Trait Associations

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