Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans.

McNeely, Marguerite J.; Boyko, Edward J.; Weigle, David S.; Shofer, Jane B.; Chessler, Steven; Leonnetti, D L; Fujimoto, W. Y.

doi:10.2337/diacare.22.1.65

Cited by 155 publications

(133 citation statements)

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“…Adiponectin is known as having anti-inflammatory, antiatherogenic and insulin-sensitizing properties 1 and it has been previously demonstrated that a low concentration of this hormone is an independent predictor of the metabolic syndrome 2 , coronary heart disease 3 and type 2 diabetes 4 . In the case of leptin, mixed results have been obtained, some studies observed that a high leptin concentration is a predictor of coronary events and type 2 diabetes independently of adiposity 5,6 while others showed that the association between leptin concentrations and these major chronic diseases is largely explained by concomitant variations in body weight or BMI 7,8 . It has been recently suggested that the leptin-to-adiponectin ratio could be a better marker of cardiometabolic alterations and insulin resistance than adiponectin or leptin alone 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, some previous studies have found sex-related differences in the link between these adipose tissuederived hormones and the development of type 2 diabetes. In fact, the association between leptin concentrations and type 2 diabetes has been shown to be stronger in men than in women 5,6 while adiponectin concentrations would be more closely associated with type 2 diabetes in women than in men 12 . Sex-related differences have also been found in the relationship between blood concentrations of these adipocytokines and markers of cardiovascular risk 11,13 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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A bstract Background/O bjective: Most of the interventional studies have investigated the impact of the diet on adiponectin and leptin concentrations only in men or in women. Consequently, it is still unknown whether the consumption of a healthy diet influences in a sex-specific manner these adipocytokines.We examined sex differences in the effects of the Mediterranean diet (MedDiet) on adiponectin and leptin concentrations and determined whether changes in these adipocytokines are associated with changes in cardiovascular risk factors in both sexes.Subjects/Methods: Participants were 38 men and 32 premenopausal women (24-53y) with slightly elevated LDL-C concentrations (3.4-4.9 mmol/l) or total cholesterol/HDL-C and cardiovascular risk factors were measured before and after a 4-week fully-controlled isoenergetic MedDiet.Results: Adiponectin concentration decreased in response to the MedDiet, but this decrease reached statistical significance only in men (P<0.001 for men and P=0.260 for women; sex-by-time interaction, P=0.072). Adjustments for body weight or waist circumference did not change results obtained.Changes in adiponectin were positively associated with concomitant variations in HDL-C in men (r=0.52, P=0.003) and with variations in apo A-1 and insulin sensitivity as calculated by both HOMA-IS and Cederholm indices in women (respectively r=0.44, P=0.021; r=0.79, P<0.001 and r=0.47, P=0.020). The MedDiet had no impact on leptin and leptin-to-adiponectin ratio in both sexes.Conclusions: Results suggest sex difference in adiponectin response to the short-term consumption of the MedDiet, with only men experiencing a decrease. Also sex-specific patterns of associations between changes in adiponectin concentration and changes in cardiovascular risk factors were observed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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“…Instead, they reported that obesity and insulin resistance explained most of the association between leptin and subsequent diabetes risk. Other studies also suggest that abdominal adiposity may modulate the association between leptin and type 2 diabetes [9,12,14,15,25].…”

Section: Discussionmentioning

confidence: 99%

“…High levels of leptin have been shown to be independently associated with diabetes in some [8][9][10][11] but not all studies [7,[12][13][14][15]18]. Of these studies, only two were UK population based studies [7,10].…”

Section: Discussionmentioning

confidence: 99%

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The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Neville

Patterson

Linden

et al. 2016

Diabetes Research and Clinical Practice

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Woodside, J. V. (2016). The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. Diabetes Research and Clinical Practice, 120,[24][25][26][27][28][29][30] Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. Abstract:Aims: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.Methods: Baseline serum levels of leptin and adiponectin were measured in 1839 nondiabetic men aged 50-60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.Results: 151 participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95%CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95%CI 0.14-0.42) relative to men in the bottom third.However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin. Conclusions:This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

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Adipocytokines and Incident Diabetes Mellitus in Older Adults

Kanaya¹,

Fyr²,

Vittinghoff³

et al. 2006

Arch Intern Med

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Background: Adipose tissue produces "adipocytokines" of uncertain clinical significance. Methods: We analyzed the relationships among adiposity, adipocytokines, glycemia, and incident diabetes mellitus in 2356 white and black adults aged 70 to 79 years in the Health, Aging, and Body Composition Study who did not have diabetes at baseline. We measured the levels of adipocytokines adiponectin, leptin, interleukin 6, tumor necrosis factor ␣, and plasminogen activator inhibitor 1. Regional fat area was determined by means of computed tomography. New diabetes was defined as a self-reported diagnosis of diabetes or as a fasting plasma glucose level of 126 mg/dL or greater (Ն7.0 mmol/L) at the second, fourth, or sixth annual examination. Results: A total of 143 participants (14.1 cases per 1000 person-years) developed diabetes across 5 years. Visceral fat area (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.10-1.60 per standard deviation increase) and body mass index (white individuals: OR, 1.65; 95% CI, 1.26-2.15 per standard deviation increase; black in-Author Affiliations are listed at the end of this article.

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Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans.

Abstract: Among Japanese Americans, increased baseline leptin levels are associated with increased risk of developing diabetes in men but not in women.

Cited by 155 publications

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Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Adipocytokines and Incident Diabetes Mellitus in Older Adults

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