Adipocytokines and Incident Diabetes Mellitus in Older Adults

Kanaya, Alka M.; Fyr, Christina Wassel; Vittinghoff, Eric; Harris, Tamara B.; Park, Seok Won; Goodpaster, Bret H.; Tylavsky, Fran; Cummings, Steven R.

doi:10.1001/archinte.166.3.350

Cited by 86 publications

(40 citation statements)

References 58 publications

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“…Levels of IL-1h, TNF-a, and PAI-1 were somewhat lower in our study than levels reported elsewhere (7,42), and the median leptin level (2.8 ng/mL) was also lower than the levels reported in the Health ABC cohort (5.5 ng/mL), the San Antonio Center for Biomarkers of Risk of Prostate cohort (7.6 ng/mL; refs. 7, 43), and in some clinical studies (24,37,43,44).…”

Section: Discussioncontrasting

confidence: 80%

“…Adipokines constitute a growing list of soluble polypeptides that are involved in complex signaling between white adipose tissue and systemic inflammatory, metabolic, and immunoregulatory pathways (2). Several subgroups of adipokines are currently recognized: (a) classic cytokines and chemokines such as tumor necrosis factor-a (TNF-a), interleukin-1h (IL-1h), IL-6, IL-8, IL-10, and tumor growth factor-h (TGF-h); (b) acute-phase proteins such as haptoglobin, serum amyloid-A, C-reactive protein, and plasminogen activator inhibitor-1 (PAI-1); and (c) other adipocyte-or macrophage-derived proteins, including leptin, nerve growth factor (NGF), monocyte chemoattractant protein-1 (MCP-1), resistin, and adiponectin (1,(3)(4)(5)(6)(7). An increasing number of other candidate adipokines are also being reported, including hepatocyte growth factor (HGF), the angiogenic protein vascular endothelial growth factor (VEGF), migrationinhibitory factor (MIF), and the iron-regulatory peptide hepcidin (3,8).…”

Section: Introductionmentioning

confidence: 99%

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Intra-individual Variation of Plasma Adipokine Levels and Utility of Single Measurement of These Biomarkers in Population-Based Studies

Lee¹,

Kallianpur²,

Xiang

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

100

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Adipokines, soluble mediators produced by adipocytes, may link adipose tissue to the inflammatory, metabolic, and immune dysregulation that characterize many obesity-related diseases. The stability of plasma adipokine levels within individuals, their seasonal variability, intercorrelations, and relationships to wellestablished measures of adiposity are incompletely defined. We measured levels of 12 adipokines [interleukin 1B (IL-1B), IL-6, IL-8, tumor necrosis factor-A (TNF-A), plasminogen activator inhibitor-1 (PAI-1), high-sensitivity C-reactive protein (hsCRP), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor (NGF), leptin, adiponectin, hepatocyte growth factor (HGF), and resistin] in four seasonal random plasma samples of 48 male participants of a population-based cohort study. The representativeness of single measurements was assessed by correlating the adipokine levels of a single, random sample with the mean levels from the remaining three samples using a bootstrap approach and using intra-class correlation coefficients (ICC). Spearman correlations between adipokine levels, age, body mass index (BMI), and waist-to-hip ratio (WHR) were estimated. Correlations between plasma adipokine levels from one random sample and the mean of the remaining three seasonal samples ranged from 0.57 to 0.89. Over the 1-year study period, the ICCs for adipokine levels ranged from 0.44 (PAI-1) to 0.83 (HGF). IL-8, MCP-1, and resistin levels were positively associated with age; HGF and PAI-1 levels were correlated with BMI and WHR. This study suggests that adipokine levels in a single blood sample may be useful biomarkers of inflammation in population-based studies of obesity-related disease. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2464 -70)

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Intra-individual Variation of Plasma Adipokine Levels and Utility of Single Measurement of These Biomarkers in Population-Based Studies

Lee¹,

Kallianpur²,

Xiang

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

100

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“…In the same study high PAI-1 level was linked to diabetes incidence. [18], In Health, Aging and Body Composition Study [19] similar results were found.…”

Section: Resultssupporting

confidence: 65%

Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI-1) in Tunisian Type 2 Diabetes Patients

Moustapha¹,

Chadhli-Chaieb²,

Mahjoub³

et al. 2017

OJEMD

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Background: PAI-1 (plasminogen activator inhibitor-1) is a powerful regulator of fibrinolysis and plasma level is high in type 2 diabetes and cardio-vascular disease, which is determined by genetic polymorphisms in PAI-1 gene and environmental factors. The aim of the study was to examine the determinants of plasma PAI-1 Ag level among type 2 diabetes patients. Methods: 491 Tunisian type 2 diabetes patients had clinical evaluation (weight, high, BMI, Waist Circumference), laboratory investigations including FBG Hb1Ac, cholesterol, triglyceride; HDL-cholesterol was done; plasma PAI-1 antigen level was done with ELISA; −675 4G/5G and −844 G/A polymorphisms of PAI-1 gene was done by PCR-ASA and PCR-RFLP respectively. Results: The mean age for our patients was 58.3 ± 10.5 years; sex-ratio = 0.92; mean PAI-1 level was 34.6 ± 21.3 ng/ml. We didn't find correlation between PAI-1 level and BMI, but we have found significant correlation between PAI-1 and waist circumference (p = 0.032), most enhanced in men (P = 0.002), T2D patients who have FBG > 11 mmol/l had PAI-1 Ag level higher than those who have FBG < 11 mmol/l (P = 0.034), but no difference found between T2D with high Hb1Ac > 8% and those with Hb1Ac < 8%, significant correlation was seen between PAI-1 level and LDL-cholesterol (P = 0.05), high correlation between PAI-1 Ag level and −675 4G/5G polymorphism genotype was seen, 4G/4G carriers had the highest PAI-1 level, 4G/5G had intermediary level and 5G/5G had the lowest level (P < 0.001). No correlation was seen between PAI-1 Ag level and −844G/A polymorphism genotypes. Using multiple variable linear regression analysis, the independent factor associated with plasma PAI-1 level was −675 4G/5G polymorphism (regression coefficient β = 4.6, P

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“…High levels of leptin have been shown to be independently associated with diabetes in some [8][9][10][11] but not all studies [7,[12][13][14][15]18]. Of these studies, only two were UK population based studies [7,10].…”

Section: Discussionmentioning

confidence: 99%

“…The evidence regarding the association between leptin and type 2 diabetes risk is conflicting, with some studies showing positive associations [6][7][8][9][10][11] and others showing no association [12][13][14][15]. Similarly, the association between adiponectin and type 2 diabetes risk…”

Section: Introductionmentioning

confidence: 99%

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

Neville

Patterson

Linden

et al. 2016

Diabetes Research and Clinical Practice

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Woodside, J. V. (2016). The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study. Diabetes Research and Clinical Practice, 120,[24][25][26][27][28][29][30] Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. Abstract:Aims: Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.Methods: Baseline serum levels of leptin and adiponectin were measured in 1839 nondiabetic men aged 50-60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.Results: 151 participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95%CI 2.67-6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95%CI 0.14-0.42) relative to men in the bottom third.However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin. Conclusions:This study provides evidence that adipokines are associated with men's future type 2 diabetes risk but not independently of other risk factors.

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Adipocytokines and Incident Diabetes Mellitus in Older Adults

Cited by 86 publications

References 58 publications

Intra-individual Variation of Plasma Adipokine Levels and Utility of Single Measurement of These Biomarkers in Population-Based Studies

Intra-individual Variation of Plasma Adipokine Levels and Utility of Single Measurement of These Biomarkers in Population-Based Studies

Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI-1) in Tunisian Type 2 Diabetes Patients

The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

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