Association between base excess and mortality in patients with congestive heart failure

Guo, Wenqin; Peng, Changnong; Liu, Qiang; Zhao, Lingyue; Guo, Wenyu; Chen, Xiehui; Li, Lang

doi:10.1002/ehf2.12939

Cited by 10 publications

(13 citation statements)

References 22 publications

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“…In the multivariable RCS model, a positive linear relationship was observed. Another study also showed a U-shaped association between BE and survival outcomes among patients with congestive heart failure ( 3 ).…”

Section: Discussionmentioning

confidence: 95%

“…Base excess has been widely used as a predictor for the diagnosis of neonatal sepsis in pre-term newborns (5), complications in cytoreductive surgery (6), or the prognosis of neonatal acute respiratory distress syndrome (7). The indicator also shows significant representativeness in heart failure (3,4). However, the association between BE and mortality among patients with AKI remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Base excess (BE) is defined as the amount of acid or alkali needed to adjust the value to the normal range ( 3 ), which is considered a pure indicator of metabolic acid–based balance ( 4 ). Base excess has been widely used as a predictor for the diagnosis of neonatal sepsis in pre-term newborns ( 5 ), complications in cytoreductive surgery ( 6 ), or the prognosis of neonatal acute respiratory distress syndrome ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury

Cheng

Zhang

et al. 2021

Front. Med.

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Objective: This study aimed to explore the association between base excess (BE) and the risk of 30-day mortality among patients with acute kidney injury (AKI) in the intensive care unit (ICU).Methods: This retrospective study included patients with AKI from the Medical Information Mart for Intensive Care (MIMIC)-IV database. We used a multivariate Cox proportional-hazards model to obtain the hazard ratio (HR) for the risk of 30-day mortality among patients with AKI. Furthermore, we utilized a Cox proportional-hazard model with restricted cubic splines (RCS) to explore the potential non-linear associations.Results: Among the 14,238 ICU patients with AKI, BE showed a U-shaped relationship with risk of 30-day mortality for patients with AKI, and higher or lower BE values could increase the risk. Compared with normal base excess (−3~3 mEq/L), patients in different groups (BE ≤ −9 mEq/L, −9 mEq/L < BE ≤ −3 mEq/L, 3 mEq/L < BE ≤ 9 mEq/L, and BE > 9 mEq/L) had different HRs for mortality: 1.57 (1.40, 1.76), 1.26 (1.14, 1.39), 0.97 (0.83, 1.12), 1.53 (1.17, 2.02), respectively. The RCS analyses also showed a U-shaped curve between BE and the 30-day mortality risk.Conclusion: Our results suggest that higher and lower BE in patients with AKI would increase the risk of 30-day mortality. BE measured at administration could be a critical prognostic indicator for ICU patients with AKI and provide guidance for clinicians.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury

Cheng

Zhang

et al. 2021

Front. Med.

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show abstract

“…Base excess has been widely used as a predictor for diagnosis of neonatal sepsis in preterm newborns 5 , complications in cytoreductive surgery 6 , or the outcome of neonatal acute respiratory distress syndrome 7 . The indicator also shows signi cant representativeness in heart failure 3,4 . However, the association of BE and mortality of patients with AKI is unclear.…”

Section: Introductionmentioning

confidence: 86%

“…Base excess (BE) refers to the amount of acid or alkali needed to adjust the value to the normal range 3 , which is considered as a pure indicator of metabolic acid-based balance 4 . Base excess has been widely used as a predictor for diagnosis of neonatal sepsis in preterm newborns 5 , complications in cytoreductive surgery 6 , or the outcome of neonatal acute respiratory distress syndrome 7 .…”

Section: Introductionmentioning

confidence: 99%

Association Between Base Excess and Mortality Among Patients in ICU with Acute Kidney Injury

Cheng

Tang

et al. 2021

Preprint

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Objective This study aimed to explore the association between base excess (BE) and risk of 30-day mortality among patients with acute kidney injury (AKI) in ICU.Methods This retrospective study including ICU patients with AKI from Medical Information Mart for Intensive Care (MIMIC)-IV database. We used multivariate Cox proportional-hazards model to calculate the hazard ratio (HR) for risk of 30-day mortality among patients with AKI. Furthermore, we utilized Cox proportional-hazard model with restrict cubic splines (RCS) to explore the potential no-linear association. Results Of all the 14238 ICU patients with AKI, BE showed U-shaped relationship with risk of 30-day mortality for patients with AKI, and higher or lower BE value could increase the risk. Compared with normal base excess (-3~3 mmol/L), patients with difference groups (BE ≤ -9mmol/L, -9 mmol/L <BE≤-3 mmol/L, 3 mmol/L <BE≤9 mmol/L and BE＞9 mmol/L) had different HR for mortality: 1.57(1.40,1.76), 1.26(1.14,1.39), 0.97(0.83,1.12), 1.53(1.17,2.02) respectively. And the RCS analyses also showed U-shaped curve between BE and 30-day mortality risk.Conclusion Our results suggest both higher and lower BE in patients with AKI would increase the risk of 30-day mortality. BE measured at administration could be a critical prognostic indicator for ICU patients with AIK and provide guidance for clinicians.

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Association between base excess and mortality in patients with congestive heart failure

et al. 2020

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Aims The relationship between baseline base excess (BE) and survival outcomes in patients with congestive heart failure (CHF) is unclear. Therefore, we aimed to investigate this relationship based on the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). Methods and results This retrospective cohort study included 5956 adult patients with CHF from the MIMIC-III database from 2001 to 2012. Using the Cox proportional-hazard analysis and Kaplan-Meier plot, we evaluated the relationship between baseline BE and all-cause death at 1 year after admission to the intensive care unit. At the 1 year follow-up, 2104 participants (35.3%) had died. There was an association between BE and all-cause death (log-rank test P < 0.0001). In the Cox regression model adjusted for demographic and clinical variables, the risk of all-cause death in the first (BE ≤ À8), second (À8 < BE ≤ À3), fourth (2 < BE ≤ 7), and fifth (BE > 7) BE groups was significantly higher than that in the third BE group (À3 < BE ≤ 2) [hazard ratio (

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Association between base excess and mortality in patients with congestive heart failure

Cited by 10 publications

References 22 publications

Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury

Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury

Association Between Base Excess and Mortality Among Patients in ICU with Acute Kidney Injury

Association between base excess and mortality in patients with congestive heart failure

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