Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Chen, Meng‐Hsiang; Lu, Cheng-Hsien; Chen, Pei-Chin; Tsai, Nai‐Wen; Huang, Chih-Cheng; Chen, Hsiu-Ling; Yang, I-Hsiao; Yu, Chiun-Chieh; Lin, Wei-Che

doi:10.1097/md.0000000000003086

Cited by 20 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For PD, greater cerebellar atrophy was associated with decreased baroreflex sensitivity,34 higher motor score on the Unified Parkinson’s Disease Rating Scale (UPDRS-III), decreased connectivity between cerebellar motor regions and the default mode, sensorimotor and dorsal attention networks,12 and a decline in executive functions 35…”

Section: Resultsmentioning

confidence: 99%

Cerebellar atrophy in neurodegeneration—a meta-analysis

Gellersen

Guo

O’Callaghan

et al. 2017

J Neurol Neurosurg Psychiatry

116

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Cerebellar atrophy in neurodegeneration—a meta-analysis

Gellersen

Guo

O’Callaghan

et al. 2017

J Neurol Neurosurg Psychiatry

116

View full text Add to dashboard Cite

“…Our findings are broadly in line with a suggested role of the central autonomous network in cardiac dysautonomic function in PD. A recent small study [Chen et al, ] in 23 patients with PD showed associations between hippocampal and insular volumes and baroreflex sensitivity, and also reported reduced right amygdala volumes, but did not find associations between amygdala volume and baroreflex sensitivity. More detailed analyses of dysautonomic subscores are warranted to further assess the nature and possible symptom and regional specificity of the central autonomic network dysfunction in PD.…”

Section: Discussionmentioning

confidence: 97%

Limbic grey matter changes in early Parkinson's disease

Xing

Schwarz

et al. 2017

Human Brain Mapping

View full text Add to dashboard Cite

The purpose of this study was to investigate local and network-related changes of limbic grey matter in early Parkinson's disease (PD) and their inter-relation with non-motor symptom severity. We applied voxel-based morphometric methods in 538 T1 MRI images retrieved from the Parkinson's Progression Markers Initiative website. Grey matter densities and cross-sectional estimates of age-related grey matter change were compared between subjects with early PD (n 5 366) and age-matched healthy controls (n 5 172) within a regression model, and associations of grey matter density with symptoms were investigated. Structural brain networks were obtained using covariance analysis seeded in regions showing grey matter abnormalities in PD subject group. Patients displayed focally reduced grey matter density in the right amygdala, which was present from the earliest stages of the disease without further advance in mild-moderate disease stages. Right amygdala grey matter density showed negative correlation with autonomic dysfunction and positive with cognitive performance in patients, but no significant interrelations were found with anxiety scores. Patients with PD also demonstrated right amygdala structural disconnection with less structural connectivity of the right amygdala with the cerebellum and thalamus but increased covariance with bilateral temporal cortices compared with controls. Age-related grey matter change was also increased in PD preferentially in the limbic system. In conclusion, detailed brain morphometry in a large group of early PD highlights predominant limbic grey matter deficits with stronger age associations compared with controls and associated altered structural connectivity pattern. This provides in vivo evidence for early limbic grey matter pathology and structural network changes that may reflect extranigral disease spread in PD. Hum Brain Mapp 38:3566-3578, 2017.

show abstract

“…Cognitive function is associated with cortical atrophy in PD patients, such that PD patients with cognitive impairments may show more extensive cortical atrophy and decreased cortical perfusion compared with PD patients without cognitive impairments (Ibarretxe-Bilbao et al, 2009; Chen et al, 2016; Lin et al, 2016) Relatedly, in PD patients with dementia, a previous study reported extensive frontal and subcortical atrophy compared with PD patients with no cognitive impairment (Borroni et al, 2015). The results of this study, meanwhile, show extensive WM changes even in the early stages of the disease.…”

Section: Discussionmentioning

confidence: 99%

Associations among Cognitive Functions, Plasma DNA, and White Matter Integrity in Patients with Early-Onset Parkinson's Disease

Chen

et al. 2017

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Early-onset Parkinson's disease (EOPD) patients are symptomatic at a relatively young age, and the impacts of the disease on both the patients and their caregivers are dramatic. Few studies have reported on the cognitive impairments seen in EOPD, and the results of these studies have been diverse. Furthermore, it is still unclear what microstructural white matter (WM) changes are present in EOPD patients. As such, we conducted this study to investigate the microstructural WM changes experienced by EOPD patients and their association with cognitive function and plasma DNA levels. We enrolled 24 EOPD patients and 33 sex- and age-matched healthy volunteers who underwent complete neuro-psychological testing (NPT) to evaluate their cognitive function and diffusion tensor imaging (DTI) scanning to determine their fiber integrity. The plasma DNA measurements included measurements of nuclear and mitochondrial DNA levels. Fractional anisotropy (FA) maps were compared using voxel-based statistics to determine differences between the two groups. The differences in DTI indices and NPT scores were correlated after adjusting for age, sex, and education. Our results demonstrate that patients with EOPD have elevated nuclear DNA levels and wide spectrums of impairments in NPT, especially in the executive function and visuospatial function domains. Exploratory group-wise comparisons of the DTI indices revealed that the patients with EOPD exhibited lower DTI parameters in several brain locations. These poorer DTI parameters were associated with worse cognitive performances and elevated plasma nuclear DNA levels, especially in the anterior thalamic radiation region. Our findings suggest that the thalamus and its adjacent anterior thalamic radiation may be important in the pathogenesis of EOPD, as they appear to become involved in the disease process at an early stage.

show abstract

Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Cited by 20 publications

References 41 publications

Cerebellar atrophy in neurodegeneration—a meta-analysis

Cerebellar atrophy in neurodegeneration—a meta-analysis

Limbic grey matter changes in early Parkinson's disease

Associations among Cognitive Functions, Plasma DNA, and White Matter Integrity in Patients with Early-Onset Parkinson's Disease

Contact Info

Product

Resources

About