2017
DOI: 10.1136/jnnp-2017-315607
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Cerebellar atrophy in neurodegeneration—a meta-analysis

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Cited by 125 publications
(120 citation statements)
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References 94 publications
(40 reference statements)
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“…Imaging results were overlaid on surface‐based cerebellar flatmaps using the SUIT toolbox based on MATLAB, version R2017a (http://au.mathworks.com/products/matlab.html) and SPM12 (http://www.fil.ion.ucl.ac.uk/spm).…”
Section: Methodscontrasting
confidence: 54%
See 1 more Smart Citation
“…Imaging results were overlaid on surface‐based cerebellar flatmaps using the SUIT toolbox based on MATLAB, version R2017a (http://au.mathworks.com/products/matlab.html) and SPM12 (http://www.fil.ion.ucl.ac.uk/spm).…”
Section: Methodscontrasting
confidence: 54%
“…Comprehensive and systematic quantification and comparisons of the patterns of cerebellar atrophy and their relations to cognitive performance across the FTD subtypes is currently lacking. A recent meta‐analysis reported cerebellar atrophy in a number of neurodegenerative disorders including bvFTD, atrophy that was disease specific . Although patterns of cerebellar atrophy have also been reported across bvFTD, SD, and PNFA, these findings were supported by a liberal statistical threshold .…”
mentioning
confidence: 99%
“…This finding is supported by previous PET studies showing higher glucose consumption in the cerebellum in patients with ALS compared with healthy controls Pagani et al, 2014). Notably, some previous VBM studies have reported decreased GMV in the cerebellum which seems to contradict our current finding (Gellersen et al, 2017;Tan et al, 2014). The underlying mechanism for such discrepancies, however, remains unknown.…”
Section: Gm Alterations In Alssupporting
confidence: 59%
“…In previous neuroimaging studies, structural and functional abnormalities of the cerebellum have been reported in patients with ALS. For example, some VBM studies found significantly decreased GMV in the cerebellum in patients with ALS (Gellersen et al, 2017;Tan et al, 2014;Thivard et al, 2007).…”
mentioning
confidence: 99%
“…Although overt ataxia is not a feature of ALS, subclinical cerebellar pathology has emerged from neuroimaging studies27 28 and appears common to neurodegenerative disorders more broadly 29. Significant ocular fixation errors have also been noted in eye-tracking experiments in ALS 30 31…”
Section: Introductionmentioning
confidence: 99%