Association Between Arterial Stiffness and Heart Failure With Preserved Ejection Fraction

Abstract

Cardiovascular diseases are the leading cause of mortality in the world. Heart failure with preserved ejection fraction (HFpEF) accounts for about half of all heart failure. Unfortunately, the mechanisms of HFpEF are still unclear, leading to little progress of effective treatment of HFpEF. Arterial stiffness is the decrement of arterial compliance. The media of large arteries degenerate in both physiological and pathological conditions. Many studies have proven that arterial stiffness is an independent risk factor for cardiovascular disorders including diastolic dysfunction. In this perspective, we discussed if arterial stiffness is related to HFpEF, and how does arterial stiffness contribute to HFpEF. Finally, we briefly summarized current treatment strategies on arterial stiffness and HFpEF. Though some new drugs were developed, the safety and effectiveness were not adequately assessed. New pharmacologic treatment for arterial stiffness and HFpEF are urgently needed.

The relationship between ambulatory arterial stiffness index and left ventricular diastolic dysfunction in HFpEF: a prospective observational study

“…Its measurement is different from the pulse wave pulse speed while it is closely correlated with aortic pulse wave velocity and the central and peripheral systolic augmentation indexes. Our findings supported that arterial stiffness might serve as risk factors for the development of HFpEF [ 29 , 30 ]. Severe diastolic dysfunction was associated with an increased risk of major adverse cardiovascular event [ 31 ].…”

Aerobic Exercise Prevents Arterial Stiffness and Attenuates Hyperexcitation of Sympathetic Nerves in Perivascular Adipose Tissue of Mice after Transverse Aortic Constriction

“…A primary finding of the present study is that aerobic exercise training prevented arterial stiffness during the development of pressure overload-induced HF. Regular aerobic exercise, regardless of intensity or duration, is effective in reducing arterial stiffness [ 18 ], which is a critical contributor to HF [ 19 ]. The mechanical stiffness of the aorta is dependent on elastin and collagen, which are prominent scaffolding proteins of ECM within the vascular wall [ 3 ].…”

Central blood pressure and arterial stiffness in patients admitted with acute decompensated heart failure

“…Хроническая сердечная недостаточность (СН) является итогом большинства сердечно-сосудистых заболеваний, и, несмотря на значительный прогресс в лечении за последние 20 лет, распространенность СН в РФ увеличилась с 6,1 до 8,2 %, и она по-прежнему остается одной из основных причин и общей, и сердечно-сосудистой смертности [1][2][3][4]. Количественная оценка центрального систолического артериального давления (цСАД) и артериальной ригидности (АР) занимает важное место в диагностике и прогнозировании течения сердечнососудистых заболеваний в разных популяциях [5,6]. Известно, что более высокая жесткость артерий и цСАД, меньшая амплификация пульсового давления (ПД) и более выраженное отражение волн связаны с худшим прогнозом [7].…”