Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition

Levin, Raz; Heresco-Levy, Uriel; Bachner‐Melman, Rachel; Israel, Salomon; Shalev, Idan; Ebstein, Richard P.

doi:10.1016/j.psyneuen.2008.12.014

Cited by 59 publications

(60 citation statements)

References 55 publications

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“…Interestingly, in Brattleboro rats, the individual startle responses and PPI are not correlated, as they are in the KO mice (146,148). More recently, polymorphisms in the promoter region of the V1a receptor gene have been associated with the PPI response to auditory stimuli in humans (297).…”

Section: Sensorimotor Gating Functionmentioning

confidence: 97%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

312

275

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The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is relatively well understood, recent years have seen an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. Deletion of V1a or V1b receptor genes in mice revealed that the contributions of these receptors extend far beyond cardiovascular or hormone-secreting functions. Together with extensively developed pharmacological tools, genetically altered rodent models have advanced the understanding of a variety of AVP systems. Our report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.

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Section: Sensorimotor Gating Functionmentioning

confidence: 97%

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Koshimizu

Nakamura

Egashira

et al. 2012

Physiological Reviews

312

275

View full text Add to dashboard Cite

show abstract

“…273 JPFSM : V1a receptors and voluntary exercise in humans and mice decreased to levels comparable to those of men with other genotypes following 5 months of IWT, suggesting that men with the TT genotype might have been physically inactive prior to IWT 18) . In addition, the AVPR1A microsatellite polymorphism RS3 was reported to be associated with social behavior, particularly in men [19][20][21][22][23][24][25] , and might be linked to lower physical activity in TT men 16) . We therefore hypothesized that adherence to the 22-month IWT program would be affected by the RS3 and rs1042615 polymorphisms of the AVPR1A in addition to previously reported factors 16,17) .…”

Section: Factors Affecting Adherence To the Long-term Iwt Programmentioning

confidence: 99%

Vasopressin V1a receptor gene and voluntary exercise: Insights from humans and animal models

Masuki

Sumiyoshi

Morikawa

et al. 2015

JPFSM

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There is no long-term exercise training regimen with high adherence and effectiveness for middle-aged and older people that is broadly available in the field. To solve this problem, we developed an exercise training regimen comprised of interval walking training (IWT) and an IT network system that only requires minimal staff support. We found that adherence to the 22-month IWT program was relatively higher than other previously reported long-term exercise programs requiring more personnel support and that the program was accompanied by greater improvements in lifestyle-related disease risk factors and physical fitness in middleaged and older people. Moreover, when congenital and acquired factors affecting adherence were assessed, we found that baseline body mass index and gender for all subjects, as well as smoking and vasopressin V1a receptor polymorphisms for men, were independent determinants of adherence to the IWT program. To elucidate the mechanism underlying the effect of V1a receptor polymorphisms on adherence to an exercise program, we assessed whether voluntary locomotion was impaired in mice genetically deficient in V1a receptors (V1a KO). We found that voluntary locomotion in wild-type mice was more probable after cerebral activation, while in V1a KO mice the probability was markedly reduced with no suppression of baroreflex control of heart rate during cerebral activation. Moreover, the findings in V1a KO mice were confirmed after local infusion of a V1a receptor antagonist into the nucleus tractus solitarii of the wild-type mice. Thus, central V1a receptors play an important role in facilitating voluntary exercise and thereby contribute to adherence to the IWT program.

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“…PCR amplification of the polymorphic RS1 and RS3 regions of the AVPR1A promoter was achieved using the following pair of primers, originally recommended by Levin et al [11]:…”

Section: Genetic Investigationsmentioning

confidence: 99%

“…At present, only one study has been published that describes correlations of the number of repeats within AVPR1A and PPI [11]. Possibly limited by a limited range of PPI in a population-based approach, these correlations could only be demonstrated by using sophisticated and non-conservative statistics.…”

Section: Introductionmentioning

confidence: 99%

No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

Schulz-Juergensen¹,

Bismarck²,

Santer³

et al. 2014

OJNeph

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Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition

Cited by 59 publications

References 55 publications

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a receptor gene and voluntary exercise: Insights from humans and animal models

No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

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Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition

Cited by 59 publications

References 55 publications

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems

Vasopressin V1a receptor gene and voluntary exercise: Insights from humans and animal models

No Correlation between &lt;i&gt;AVPR&lt;/i&gt;1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis

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No Correlation between <i>AVPR</i>1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis