Association between appendicectomy in females and subsequent pregnancy rate: a cohort study

Li, Wei; MacDonald, Thomas M.; Shimi, S. M.

doi:10.1016/j.fertnstert.2012.05.016

Cited by 9 publications

(14 citation statements)

References 31 publications

(32 reference statements)

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“…First, appendicitis is not significantly associated with subsequent future infertility in women. This is similar to other studies, such as [17]. This study reported that appendectomy is associated with an increased pregnancy rate in a large cohort of patients (76,426 appendectomies and 152,852 comparators).…”

Section: Discussionsupporting

confidence: 91%

The effect of appendectomy in future tubal infertility and ectopic pregnancy: a systematic review and meta-analysis

Elraiyah

Hashim

Elamin

et al. 2014

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 91%

The effect of appendectomy in future tubal infertility and ectopic pregnancy: a systematic review and meta-analysis

Elraiyah

Hashim

Elamin

et al. 2014

Journal of Surgical Research

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“…The results from this population-based study confirmed the previously reported observation of a higher pregnancy rate and shorter time to pregnancy (TTP) following appendicectomy 10,11 . The adjusted HR for the pregnancy outcome in females who had a previous appendicectomy was 1.34…”

Section: Discussionsupporting

confidence: 90%

“…and 54% respectively in the two cohorts of patients who had appendicectomy when compared with comparators 10,11 . A Swedish study similarly found an association between removal of a normal appendix or a non-perforated appendix and a higher subsequent birth rate in women aged less than 25 years 12 .…”

Section: Wei Phd a Introductionmentioning

confidence: 96%

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Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study

Wei

MacDonald

Shimi

2016

Fertility and Sterility

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CapsuleIn a population-based study, previous appendicectomy and /or tonsillectomy were associated with an increase in subsequent pregnancy rates and shorter time to pregnancy after surgery. 1 ABSTRACTObjective: To study pregnancy rates after appendicectomy and /or tonsillectomy.Design: A population based cohort study using the UK primary health care based Clinical Practice Research Datalink (CPRD). Setting: UK Primary CarePatients: Female patients who underwent appendicectomy, tonsillectomy or both between 1987 and 2012 and appropriate comparators.Intervention: Timed follow up until first pregnancy after surgery. The association between prior surgery and subsequent pregnancy was determined by Cox regression models. Main Outcome Measures:Pregnancy rate and time to first pregnancy after surgery. Results:The analyses included 54,675 appendicectomy only patients, 112,607 tonsillectomy only patients, 10,340 patients who had both appendicectomy and tonsillectomy with 355,244 comparators matched for exact age and practice from the rest of female patients in the database. There were 29,732 (54.4%), 60,078 (53.4%) and 6,169 (59.7%) pregnancies in the appendicectomy only, tonsillectomy only and both appendicectomy tonsillectomy cohorts respectively vs 155,079 (43.7%) in the comparator cohort during a mean follow up of 14.7 (SD, 9.7) years. Adjusted hazard ratios (HRs) for subsequent birth rates were 1.34 (95% CI 1.32 to 1.35), 1.49 (95%CI 1.48 to 1.51) and 1.43 (95%CI 1.39 to 1.47), respectively. Time to pregnancy was shortest after both appendicectomy and tonsillectomy followed by appendicctomy only and then tonsillectomy only in comparison to the rest of the population. Conclusions:Appendicectomy and /or tonsillectomy were associated with increased subsequent pregnancy rates and shorter time to pregnancy. The effect of the surgical procedures on the pregnancy outcome was cumulative.

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“…Ileus was the most reported outcome as 16 of the included studies reported on this complication (22, 26, 27, 29, 33, 36, 37, 41–44, 48, 52, 53, 55, 56), whereas only four of the included studies reported on incisional hernia (32, 38, 44, 56). Furthermore, six of the included studies reported on inflammatory bowel disease (34, 35, 40, 45, 47, 49), six on cancer (20, 21, 24, 25, 46, 51), five on fertility (23, 30, 31, 50, 54), and three on mortality (26, 28, 39).…”

Section: Resultsmentioning

confidence: 99%

Long-Term Complications of Appendectomy: A Systematic Review

2018

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Background and Aims: appendectomy is a common surgical procedure, but no overview of the long-term consequences exists. our aim was to systematically review the long-term complications of appendectomy for acute appendicitis.Materials and Methods: This systematic review was reported according to the preferred reporting items for systematic reviews and meta-analyses guidelines. a protocol was registered on prospero (Crd42017064662). The databases pubmed and embase were searched for original reports on appendectomy with n ≥ 500 and follow-up >30 days. The surgical outcomes were ileus and incisional hernia; other outcomes were inflammatory bowel disease, cancer, fertility, and mortality.Results: we included 37 studies. The pooled estimate of the ileus prevalence was 1.0% over a follow-up period of 4.6 (range, 0.5-15) years. regarding incisional hernia, we found a pooled estimate of 0.7% prevalence within a follow-up period of 6.5 (range, 1.9-10) years. Ulcerative colitis had a pooled estimate of 0.15% prevalence in the appendectomy group and 0.19% in controls. The opposite pattern was found regarding Crohn's disease with a pooled estimate of 0.20% prevalence in the appendectomy group and 0.12% in controls. no clear pattern was found regarding most of the examined cancers in appendectomy groups compared with background populations. pregnancy rates increased after appendicitis compared with controls in most studies. mortality was low after appendectomy.Conclusion: appendectomy had a low prevalence of long-term surgical complications. we did not find any significant other long-term complications, though the prevalence of Crohn's disease was higher and the prevalence of ulcerative colitis was lower after appendectomy than in controls. appendectomy did not impair fertility.

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Association between appendicectomy in females and subsequent pregnancy rate: a cohort study

Cited by 9 publications

References 31 publications

The effect of appendectomy in future tubal infertility and ectopic pregnancy: a systematic review and meta-analysis

The effect of appendectomy in future tubal infertility and ectopic pregnancy: a systematic review and meta-analysis

Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study

Long-Term Complications of Appendectomy: A Systematic Review

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