Association between apolipoprotein E polymorphism and macroalbuminuria in patients with non-insulin dependent diabetes mellitus

Ha, Sungji; Park, Hong Su; Kim, Kyung Wook; Kim, Seung Jung; Kim, Dohun; Kim, Jung Ho; Lee, Ho Yung; Han, Dae Suk

doi:10.1093/ndt/14.9.2144

Cited by 30 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the large number of studies into this issue has failed to reach a definitive conclusion. 1,6,13,15,42 As was the case in our study, several others also claim that carrying e2 allele may increase the risk for DN. For instance, Araki et al showed in their prospective study that the presence of e2 allele increased the risk for DN.…”

Section: Discussionsupporting

confidence: 81%

“…29 Case-control studies with similar results also exist. 1,15,30,44 Additionally, the single histopathological study conducted by Guan et al 13 also found an association between diabetes-related glomerulopathy and APO E2. On the other hand, some other studies found no relationship between APO E2 and DN.…”

Section: Discussionmentioning

confidence: 93%

“…It is a part of VLDL, IDL, chylomicrons, chylomicron traces, and HDL. 1,28 It carries lipids to the intracellular environment via LDL and APO E receptors. The APO E gene is localized in the 19th chromosome and consists of three isoforms (E2, E3, and E4) coded by three codominant alleles (ε2, ε3, and ε4).…”

Section: Discussionmentioning

confidence: 99%

“…1 The two most significant risk factors known today in its development are hyperglycemia and high blood pressure. 2 Genetic predisposition has also been recently suggested as another cause of DN.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of the Angiotensinogen M235T and APO E Gene Polymorphisms in Turkish Type 2 Diabetic Patients with and without Nephropathy

et al. 2011

View full text Add to dashboard Cite

Background: Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2 diabetes, and to compare genotype and allele distributions among DN patients, non-DN patients, and healthy controls. Methods: AGT M235T and APO E genotype and allele analysis were performed in 111 DN patients, 108 non-DN patients, 106 healthy control subjects for APO E genotype, and 100 for AGT M235T genotype polymorphism. APO E and AGT M235T genotype were determined by RFLP-PCR. Results: The frequencies of APO E ε2/3, ε 3/3, ε 3/4 genotypes were 22.7%, 60%, 60%, respectively, among DN patients and 6.6%, 80%, 10.4%, respectively (p < 0.001), in the non-DN patients. The frequencies of AGT M235T MM, MT, TT genotypes among the same groups were 17%, 46%, 37% and 21%, 63%, 16%, respectively (p < 0.02). Having the ε2/3 genotype and TT genotype increased the risk for DN nephropathy [4.8-fold (95% CI: 1.94-11.67), 2.9-fold (95% CI: 1.27-6.69), respectively]. Conclusion: Our study has shown that AGT M235T TT genotype and APO E ε 2/3 genotype may be linked to a risk for DN among Turkish population.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of the Angiotensinogen M235T and APO E Gene Polymorphisms in Turkish Type 2 Diabetic Patients with and without Nephropathy

et al. 2011

View full text Add to dashboard Cite

show abstract

“…These raised the possibility that the ε2 allele increased the risk of DN in Chinese, Japanese and Korean patients with T2DM [7][8][9]. However, additional few studies in East Asian populations conflicted with this result [10].…”

mentioning

confidence: 99%

The apolipoprotein E (APOE) gene and the risk of diabetic nephropathy (DN): a meta-analysis in East Asian populations

Feng

Zhu

et al. 2010

Asian Biomedicine

View full text Add to dashboard Cite

Background: Several studies have examined the association between DN and the APOE gene, but the results have been inconsistent. Objective: Determine whether APOE is a risk factor for DN by a meta-analysis. Methods: A meta-analysis was performed using all findings of 16 similar case-control studies in East Asian to evaluate the effect of APOE as a risk factor for DN. Several electronic databases were searched for relevant articles up to 2009. After data collection, a meta-analysis was used to assess heterogeneity, combine results and evaluate variations by using software STATA SE 9.0. Publication bias was examined by the Egger's linear regression test and fail-safe number. Conclusion:The ε2 allele conferred a higher risk of DN in East Asians, and no significant result was obtained with the ε4 allele.

show abstract

Apolipoprotein E and Progression of Chronic Kidney Disease

Hsu¹

2005

JAMA

View full text Add to dashboard Cite

Association between apolipoprotein E polymorphism and macroalbuminuria in patients with non-insulin dependent diabetes mellitus

Abstract: Apo epsilon2 allele and epsilon2 carrier frequencies were significantly higher in macroalbuminuria group. These results suggest that epsilon2 allele may be associated with the development of clinical albuminuria in Korean patients with NIDDM.

Cited by 30 publications

References 23 publications

Association of the Angiotensinogen M235T and APO E Gene Polymorphisms in Turkish Type 2 Diabetic Patients with and without Nephropathy

Association of the Angiotensinogen M235T and APO E Gene Polymorphisms in Turkish Type 2 Diabetic Patients with and without Nephropathy

The apolipoprotein E (APOE) gene and the risk of diabetic nephropathy (DN): a meta-analysis in East Asian populations

Apolipoprotein E and Progression of Chronic Kidney Disease

Contact Info

Product

Resources

About