Association between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence from a Meta-Analysis of 40 Studies

Yin, Yan-Wei; Sun, Qianqian; Zhang, Beibei; Hu, Aimin; Liu, Hongli; Wang, Qi; Hou, Zhiyong

doi:10.1371/journal.pone.0066924

Cited by 37 publications

(35 citation statements)

References 16 publications

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“…Results with P values less than 0.05 are in bold font. It is well known that the APOE variant is a predictor of plasma lipid levels in cardiovascular disease (Yin et al, 2013). Therefore, we further stratified the data analysis into different lipids by rs4420638 genotype.…”

Section: Resultsmentioning

confidence: 99%

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Huang

Gao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to the risk of CHD in Han Chinese. In addition, we performed a meta-analysis to evaluate the association between rs4420638 and CHD in Europeans and Asians. The results show that rs4420638 is significantly correlated with increased CHD risk in male Han Chinese [P = 0.040, odds ratio (OR) = 1.34, 95% confidential interval (95%CI) = 1.01-1.78] and is likely to increase the risk of CHD under the dominant model in males (P = 13415 rs4420638 and CHD in Han Chinese men ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13414-13424 (2015) 0.036, OR = 1.38, 95%CI = 1.02-1.88). A further subgroup analysis by rs4420638 genotype found a significant association of rs4420638 AA with high-density lipoprotein cholesterol (HDL-C) (P = 0.012) and APOA-I levels (P = 0.0001) in males. The meta-analysis suggests that rs4420638 significantly increases the risk of CHD (OR = 1.18, 95%CI = 1.14-1.22, P < 0.0001, fixed-effect method). Our case-control study shows that rs4420638 genotype AA has a significant association with the concentrations of circulating HDL-C and APOA-I in CHD in Han Chinese males. The meta-analysis suggests that rs4420638 is associated with CHD risk in Europeans and Asians.

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Section: Resultsmentioning

confidence: 99%

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Huang

Gao

et al. 2015

Genet. Mol. Res.

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“…Although several recent meta-analyses explored the genetic risk of APOE polymorphisms in CAD [14][15][16], our analysis was the first comprehensive assessment in PCAD. Merging the data of all eligible publications revealed that subjects with the ε4 allele conferred 62% more predisposition to PCAD, while ε4 carriers had 65% higher risk for PCAD.…”

Section: Discussionmentioning

confidence: 99%

“…The analysis conducted by Hong Xu found that the ε2 allele in APOE decreased the prevalence of myocardial infarction while the ε4 allele increased the incidence [14]. Two other meta-analyses conducted in the Chinese population also found a high risk of the ε4 allele for CAD [15,16]. However, no meta-analysis explored the genetic risk of APOE in PCAD.…”

Section: Introductionmentioning

confidence: 99%

Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis

Zhao

Lei

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Although several studies have explored the genetic polymorphisms of apolipoprotein E (APOE) and their impact on premature coronary artery disease (PCAD), there is still some controversy regarding the significance of their association. Our aim is to estimate the association between APOE polymorphisms and PCAD via meta-analysis. Methods: All relevant case-control studies and cohort studies published in Chinese or English prior to March 2016 were searched for in electronic databases. Detailed information concerning each piece of literature was independently extracted by two researchers. We used STATA11.0 to process all data and to determine the pooled odds ratio (OR). Altogether, four genetic models were applied to calculate OR and 95% confidence interval (CI): (1) ε2 allele vs. ε3 allele; (2) ε2 carriers vs. ε3/3; (3) ε4 allele vs. ε3 allele; (4) ε4 carriers vs. ε3/3. Results: Eighteen studies concerning APOE polymorphisms and their impact on PCAD were included in the final analysis. The pooled analysis displayed that the ε2 allele and ε2 carriers increased the risk of PCAD significantly among Asians (OR 1.54; 95% CI, 1.09-2.17; OR 1.65;

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“…La presencia del alelo ε4 se considera un factor de riesgo genético para la aparición de enfermedades cardiovasculares, como el infarto de miocardio, y de la enfermedad de Alzheimer (23)(24)(25), por lo que su estudio puede servir de tamización inicial en los programas de prevención de las hiperlipidemias y de la enfermedad de Alzheimer cuando su frecuencia sea muy significativa en las poblaciones estudiadas.…”

Section: Alelo ε4unclassified

Análisis del polimorfismo del gen APOE en la población de Barranquilla, Colombia

et al. 2015

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Introducción. La variabilidad genética del polimorfismo del gen APOE se considera un importante factor asociado a la predisposición a las enfermedades que afectan el metabolismo lipídico, a las enfermedades coronarias y a la enfermedad de Alzheimer, entre otras. En este sentido, es útil conocer este factor de riesgo en diferentes poblaciones y grupos étnicos. Objetivos. Analizar el polimorfismo del gen APOE y determinar las frecuencias alélicas y genotípicas de una muestra representativa de la población de Barranquilla, Colombia. Materiales y métodos. Se hizo en Barranquilla un estudio descriptivo y comparativo de 227 individuos no relacionados. Resultados. El alelo ε3 se presentó con mayor frecuencia (85 %), seguido del alelo ε4 (13 %) y, con menor frecuencia, el alelo ε2 (1,8 %). Los genotipos observados fueron los siguientes: ε3/ε3 en 71,8 %, ε3/ε4 en 24,2 %, ε2/ε3 en 2,2 %, ε2/ε4 en 1,3 % y ε4/ε4 en 0,4 %. El genotipo ε2/ε2 no se encontró en este estudio. La muestra representativa de la población estaba en equilibrio de Hardy-Weinberg. Conclusiones. Las frecuencias alélicas ε3 y el genotipo ε3/ε3 encontrados en la población estudiada, fueron similares a lo informado por la literatura científica en países como Brasil, México y Colombia, y en algunos grupos étnicos amerindios colombianos. No se encontró el genotipo ε2/ε2, resultado que coincide con otras poblaciones estudiadas a nivel mundial. La frecuencia del alelo ε4 y sus genotipos asociados en esta población, podría estar relacionada con la presencia de enfermedades como la hipercolesterolemia, el infarto de miocardio y la enfermedad de Alzheimer.Palabras clave: apolipoproteínas E, polimorfismo genético, población, alelos, Colombia. doi: http://dx.doi.org/10.7705/biomedica.v36i1.2612 APOE gene polymorphism analysis in Barranquilla, ColombiaIntroduction: The genetic variability present in the APOE gene polymorphism is considered an important factor associated with predisposition to diseases affecting lipid metabolism, as well as heart diseases and Alzheimer's disease, among others. Understanding it as a risk factor in different populations and ethnic groups is a useful tool. Objective: To analyze the APOE gene polymorphism and determine allelic and genotypic frequencies of a representative sample of population from Barranquilla, Colombia. Materials and methods:We performed a descriptive and comparative study. The sample size was 227 unrelated individuals from Barranquilla, Colombia Results: The most frequent allele was the ε3, with 85%, followed by the ε4 allele (13%) and ε2 (1.8%). The genotypes found were: ε3/ε3: 71.8%, ε3/ε4: 24.2%, ε2/ε3: 2.2%, ε2/ε4: 1.3% and ε4/ε4: 0.4%. The ε2/ε2 genotype was not found in this study. The sample exhibited the Hardy-Weinberg equilibrium. Conclusion: The frequency of the ε3 allele and the ε3/ε3 genotype was similar to that reported in the literature in countries like Brazil, Mexico, Colombia, and in some Colombian Amerindian ethnic groups. The ε2/ε2 genotype was absent. This result is consistent with those found in oth...

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Association between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence from a Meta-Analysis of 40 Studies

Cited by 37 publications

References 16 publications

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis

Análisis del polimorfismo del gen APOE en la población de Barranquilla, Colombia

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