Association between ambient temperature and hypertensive disorders in pregnancy in China

Xiong, Tao; Chen, Peiran; Mu, Yi; Li, Xiaohong; Di, Baofeng; Li, Jierui; Qu, Yi; Tang, Jun; Liang, Juan; Mu, Dezhi

doi:10.1038/s41467-020-16775-8

Cited by 56 publications

(40 citation statements)

References 47 publications

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“…In Brazil, Melo et al observed that gestational hypertension increased significantly during the colder months, especially in August when the southern hemisphere is in winter [ 17 ]. A recent study from China found that exposure to very cold weather before pregnancy increased the risk of preeclampsia, eclampsia and gestational hypertension; and conversely, exposure to cold in the first half of pregnancy reduces, while hot weather increases the risk of hypertensive disorders in pregnancy [ 64 ]. But, Elongi et al found no association between gestational hypertension and seasonal changes, during their 36-month study, in Mississippi [ 65 ], which is consistent with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

Universal Thermal Climate Index (UTCI) and adverse pregnancy outcomes in Ahvaz, Iran

et al. 2022

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Background Climate change may jeopardize the health of mothers and their offspring. There are few studies on the association between increasing temperature and pregnancy outcomes. The aim of this study was to investigate the relation between Universal Thermal Climate Index (UTCI) and adverse pregnancy outcomes including stillbirth, low birth weight (LBW), preterm labor (PTL), spontaneous abortion (SA), preeclampsia and hypertension in Ahvaz, Iran. Methods Distributed Lag Non-linear Models (DLNM) combined with quasi-Poisson regression were used to research the effect of UTCI on adverse pregnancy outcomes. The effect of time trend, air pollutants (NO2, SO2 and PM10), and weekdays were adjusted. Results The results showed that the low values of UTCI index (11.6 °C, in lags 0–6, 0–13) caused significant increase in the risk of preterm labor. However, hot thermal stress (high UTCI) significantly increased the risk of stillbirth in lag 0–13. We did not observe any significant relation between UTCI and other pregnancy outcomes in this study. Conclusions It seems like both hot and cold weathers can be associated with adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Universal Thermal Climate Index (UTCI) and adverse pregnancy outcomes in Ahvaz, Iran

et al. 2022

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“…Another limitation was that the pregnant women in this study cohort were generally younger than 35 years old; therefore, research on FGF21 in GDM women over 35 years old still needs to be performed. However, studies have shown that pregnant women younger than 35 years old account for more than 85% of the total number of pregnant women in China ( 41 ). Therefore, the findings of this study are still very instructive and interesting.…”

Section: Discussionmentioning

confidence: 99%

FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study

Wang

Yuan

et al. 2021

Front. Endocrinol.

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BackgroundAs an important endocrine hormone regulating glucose metabolism, fibroblast growth factor 21 (FGF21) is increased in individuals with gestational diabetes mellitus (GDM) after 24 gestational weeks. However, it is unknown whether the increase in FGF21 precedes the diagnosis of GDM.MethodsIn this nested case-control study, 133 pregnant women with GDM and 133 pregnant women with normal glucose tolerance (NGT) were identified through propensity score matching, and serum FGF21 levels were measured at 14 to 21 gestational weeks, before GDM is routinely identified. The differences in FGF21 levels were compared. The association between FGF21 and the occurrence of GDM was evaluated using logistic regression models with adjustment for confounders.ResultsThe serum FGF21 levels of the GDM group at 14 to 21 gestational weeks were significantly higher than those of the NGT group overall (P < 0.001), with similar results observed between the corresponding BMI subgroups (P < 0.05). The 2nd (OR 1.224, 95% CI 0.603–2.485), 3rd (OR 2.478, 1.229–5.000), and 4th (OR 3.419, 95% CI 1.626–7.188) FGF21 quartiles were associated with greater odds of GDM occurrence than the 1st quartile after multivariable adjustments.ConclusionsThe serum FGF21 levels in GDM groups increased in the early second trimester, regardless of whether participants were stratified according to BMI. After adjusting for confounding factors, the FGF21 levels in the highest quartile were associated with more than three times higher probability of the diagnosis of GDM in the pregnancy as compared to levels in the first quartile.

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“…In addition, extreme heat exposure during pregnancy affects glucose metabolism and increases insulin resistance, leading to gestational diabetes [16][17][18]. Moreover, some evidence indicates that elevated temperature causes maternal hypertension, especially pre-eclampsia, one of the main risk factors for global maternal mortality [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Elevated Ambient Temperature on Maternal, Foetal, and Neonatal Outcomes: A Scoping Review

Dalugoda

Kuppa

Phung

et al. 2022

IJERPH

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This scoping review provides an overview of the published literature, identifies research gaps, and summarises the current evidence of the association between elevated ambient temperature exposure during pregnancy and adverse maternal, foetal, and neonatal outcomes. Following the PRISMA extension for scoping reviews reporting guidelines, a systematic search was conducted on CINAHL, PubMed, and Embase andincluded original articles published in the English language from 2015 to 2020 with no geographical limitations. A total of seventy-five studies were included, conducted across twenty-four countries, with a majority in the USA (n = 23) and China (n = 13). Study designs, temperature metrics, and exposure windows varied considerably across studies. Of the eighteenheat-associated adverse maternal, foetal, and neonatal outcomes identified, pre-term birth was the most common outcome (n = 30), followed by low birth weight (n = 11), stillbirth (n = 9), andgestational diabetes mellitus (n = 8). Overall, papers reported an increased risk with elevated temperature exposures. Less attention has been paid to relationships between heat and the diverse range of other adverse outcomes such as congenital anomalies and neonatal mortality. Further research on these less-reported outcomes is needed to improve understanding andthe effect size of these relationships with elevated temperatures, which we know will be exacerbated by climate change.

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Association between ambient temperature and hypertensive disorders in pregnancy in China

Cited by 56 publications

References 47 publications

Universal Thermal Climate Index (UTCI) and adverse pregnancy outcomes in Ahvaz, Iran

Universal Thermal Climate Index (UTCI) and adverse pregnancy outcomes in Ahvaz, Iran

FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study

Effect of Elevated Ambient Temperature on Maternal, Foetal, and Neonatal Outcomes: A Scoping Review

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