Association Between Alpha-2a-adrenergic Receptor Gene and ADHD Inattentive Type

A review of psychiatric genetics research in the Brazilian population

“…59 Schmitz et al showed, in a case control study with a sample of 100 ADHD children and 100 non-ADHD children, an association between ADHD inattentive type and this ADRA2A gene polymorphism. 60 Guimaraes et al found, in a sample of 243 ADHD children, that the polymorphism His452 allele of the 5HT2A gene may be associated with ADHD in boys, but not in girls, which suggests a gender effect on the genetic susceptibility to the disorder. In the same group of patients, these authors did not find association with a SLC6A4 gene polymorphism.…”

No association between dopaminergic polymorphisms and intelligence variability in attention-deficit/hyperactivity disorder

“…Expression of a total of 1754 out of 22 000 probe sets showed significant correlations with PMI (Pearson's correlation, P < 0.05), consistent with the previous notion that PMI is a minor confounding factor compared with other factors (Supplementary Figure 1). In contrast to sample pH, which is closely associated with terminal condition of death and a major confounding factor for gene expression studies, [1][2][3][4][5]7,8 PMI did not correlate with indicators of RNA integrity or sample quality (Figure 1a). Together with the fact that PMI did not correlate with sample pH (Supplementary Figure 2), we concluded that PMI did not affect quality of DNA microarray data.…”

“…The extensive diagnostic process, also based in DSM-IV criteria, used in this sample have been fully described elsewhere. 8 The estimated IQ score was obtained from the Vocabulary and Block Design subtests of the Wechsler Intelligence Scale -Third Edition (WISC III) 9 for children and from the same sub-tests of the WAIS-R 10 for adults, both administered by trained psychologists. The DRD4 region containing the 48 bp repeat and the 40 bp VNTR site at DAT1 gene was amplified by the polymerase chain reaction (PCR) as described by Roman et al 6 The IQ scores were compared among groups through analysis of variance in the unadjusted model and Letters to the Editor through analysis of covariance controlling for age, and sex.…”

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder

“…[60] Alfa 2A reseptör geni kromozom 10q24-26 yerleşimlidir. [61] Çeşitli ça-lışmalarda -1291 C>G tek nükleotit polimorfizmi (TNP) G allelinin DEHB için artmış riskle ilişkili olduğu gösterilmiştir. [61,62] Fakat aile temelli bir çalışmada -1291 C>G TNP'nin rolüne dair kanıt elde edilmemiştir.…”

“…[61] Çeşitli ça-lışmalarda -1291 C>G tek nükleotit polimorfizmi (TNP) G allelinin DEHB için artmış riskle ilişkili olduğu gösterilmiştir. [61,62] Fakat aile temelli bir çalışmada -1291 C>G TNP'nin rolüne dair kanıt elde edilmemiştir. [63] Park ve arkadaşları alfa 2A reseptör geninde farklı bir polimorfizmi incelemişler ve DEHB kombine alttipinde ek olarak DraI polimorfizmi T allelinin yüksek risk ile ilişkili olduğunu bildirmiştir.…”