Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study

Tsai, Jeng-Dau; Chen, Hsuan-Ju; Ku, Min‐Sho; Chen, Shan-Ming; Hsu, Chih-Chuan; Tung, Min‐Che; Lin, Chun‐Pin; Chang, Hsing-Yi; Sheu, Ji-Nan

doi:10.1007/s00467-017-3750-0

Cited by 29 publications

(26 citation statements)

References 37 publications

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“…In this large cohort of community children attending primary schools, this study shows that either snoring or unrefreshing sleep are associated with a higher prevalence of NE. Our findings corroborate those of previous reports on NE and SDB in clinical referral samples, 4,5,7,21 as well as the findings of the community-based cohorts reported to date, 18,22 and that adenotonsillectomy for SDB children with adenotonsillar hypertrophy resolved not only SDB but also NE. 8-10,23,24 Furthermore, our study also suggested that frequent symptoms indicative of unrefreshing sleep are also associated with higher NE prevalence.…”

Section: Discussionsupporting

confidence: 93%

Nocturnal enuresis and sleep disordered breathing in primary school children: Potential implications

Wada

Kimura

Tajima

et al. 2018

Pediatric Pulmonology

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The pathogenic mechanisms linking snoring and unrefreshing sleep to increased risk of NE are unknown. However, snoring, a surrogate reporter of SDB, is associated with increased urine production, while unrefreshing sleep may result from disrupted sleep facilitating increased sleep pressure and elevated arousal thresholds. Thus, both SDB and unrefreshing sleep are potential independent risk factors of NE in school age children.

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Section: Discussionsupporting

confidence: 93%

Nocturnal enuresis and sleep disordered breathing in primary school children: Potential implications

Wada

Kimura

Tajima

et al. 2018

Pediatric Pulmonology

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“…Karakas HB et al 7compared 112 children with PNE in terms of upper airway pathologies with control group 113 and reported that AR was equal in both groups. In contrast to this study, Tsai JD et al (17) reported that AR increases the frequency of PNE in a study on 8616 children by using TNHIRD (Taiwan National Health Insurance Research) data between 2007-2012. However, in our presented study, it was observed that AR did not change the PNE frequency.…”

Section: Discussioncontrasting

confidence: 78%

Üst solunum yolu obstrüktif patolojiler ile primer nokturnal enürezis arasındaki ilişkinin değerlendirilmesi

Şen

Güler

2019

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: The aim of this study was to determine the relationship between primary nocturnal enuresis (PNE) and upper airway obstructive pathologies such as allergic rhinitis (AR), nasal septum deviation (NSD), adenoid hypertrophy (AD) and tonsillar hypertrophy (TH). Methods: The study included 78 volunteer PNE patients (42 males, 36 females; mean age: 7.2 ± 1.6 years, range: 5.4 to 11.6 years) who applied to Pediatrics and Urology outpatient clinics of a second-stage hospital between June 1, 2018 and September 1, 2018. The control group included 72 volunteer children (34 males, 38 females; mean age: 7.6 ± 1.4 years, range: 5.1 to 12.7 years) who were admitted to the inpatient outpatient clinics of the same hospital and had no PNE complaint. All participants included in the study were applied routine physical examination, flexible fiberoptic nasopharyngoscopy and score for allergic rhinitis (SFAR) questionnaire. Brodsky scale and fiberendoscopic findings were used to classify tonsil and adenoid dimensions respectively. Results: There was no significant difference between PNE (+) and PNE (-) groups in terms of age and gender (respectively p = 0.203 and p = 0.819). Although AR and NSD were similar in both groups, the ratio of AH and TH was statistically significantly higher in the PNE (+) group (p = 0.016 and p = 0.05, respectively). Conclusion: Adenotonsillar hypertrophy must be considered in children with primary nocturnal enuresis.

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“…A study based on a large national population database has shown that OSAS and snoring are more common in the group with enuresis than in the control group (1.8% vs. 0.6%; 1.3% vs. 0.6%, respectively). [11] Respiratory problems in children may affect or worsen NE. The link between OSAS and NE is due to an increased respiratory effort against an obstructed airway in children with SDB that may cause increased release of both brain and atrial natriuretic peptides from cardiac myocytes after cardiac wall distension owing to increased negative intrathoracic pressure.…”

Section: Discussionmentioning

confidence: 99%

Medical comorbidity of nocturnal enuresis in children

et al. 2019

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Introduction:The purpose of this study was to evaluate the characteristics of patients with nocturnal enuresis (NE).Methods:We enrolled 403 children with NE referred to the Services of Pediatrics, Campus Bio-Medico University Hospital of Rome between June 2013 and July 2018. We excluded 2 children, respectively, with renal agenesis and chromosomopathy.Results:Of the 401 patients, 101 girls (25.2%) and 300 boys (74.8%), aged 5–16 years; mean age at first visit 8.8 ± 2.44 years. During the physical examination, we asked the patients and their parents specific questions to identify signs and symptoms of voiding disorders and comorbid conditions. In addition, we evaluated family history and behavioral characteristics of patients. In this study, NE was heredity in the 31.2% of cases. We found urogenital abnormalities in 15.7% of cases, constipation in 14.5% of cases, innocence heart murmur in 21.4% of cases and parasomnias in a good percentage of cases, especially snoring (13.7%), restless sleep (5.7%), somniloquy (23.7%) and bruxism (14.7%).Conclusions:Our experience demonstrates that there are a lot of comorbidities that are associated with NE and can influence the prognosis and the response to the therapy in these children.

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Association between allergic disease, sleep-disordered breathing, and childhood nocturnal enuresis: a population-based case-control study

Abstract: Allergic diseases and SDB are associated with increased odds of childhood NE. The odds of NE increased with the number of comorbid allergic diseases present.

Cited by 29 publications

References 37 publications

Nocturnal enuresis and sleep disordered breathing in primary school children: Potential implications

Nocturnal enuresis and sleep disordered breathing in primary school children: Potential implications

Üst solunum yolu obstrüktif patolojiler ile primer nokturnal enürezis arasındaki ilişkinin değerlendirilmesi

Medical comorbidity of nocturnal enuresis in children

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