Association between alcohol consumption and systolic ventricular function: A population-based study

Alcohol Consumption, Left Atrial Diameter, and Atrial Fibrillation

“…Acute alcohol exposure enhances electrophysiologic vulnerability to AF in experimental models, but our understanding of the mechanisms underlying the observed epidemiological associations between alcohol and AF remains incomplete. The paucity of data relating to the downstream structural and electrophysiological effects of chronic alcohol consumption on the atrium stand in contrast to the abundance of data linking alcohol to ventricular enlargement and systolic dysfunction …”

“…Exposure to AF risk factors influences tracking of LAD over the adult life course, LA enlargement preceding AF, and higher LAD conferring an increased risk for incident and recurrent AF . Chronic alcohol consumption has been associated with ventricular dilation and left ventricular dysfunction . Recent studies suggest that atrial remodeling and AF may also result from alcohol exposure .…”

“…The paucity of data relating to the downstream structural and electrophysiological effects of chronic alcohol consumption on the atrium stand in contrast to the abundance of data linking alcohol to ventricular enlargement and systolic dysfunction. 25 Understanding the mechanisms underlying the relationships between alcohol and AF is important for several reasons. First, some patients may benefit from moderate consumption of alcohol, [26][27][28] and identifying those at risk for cardiovascular-system harm (such as given evidence of LA enlargement) may help to counsel patients regarding their specific risks versus benefits appropriately.…”

“…9,[29][30][31][32] Chronic alcohol consumption has been associated with ventricular dilation and left ventricular dysfunction. 1,25,28 Recent studies suggest that atrial remodeling and AF may also result from alcohol exposure. 8 We sought to better understand the associations between chronic alcohol consumption, atrial remodeling, and incident AF.…”

Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

“…LV systolic function was determined by LVEF (%), which was calculated from the apical four chamber view [14,15]. Incident LV systolic dysfunction was defined as LVEF 50% at follow-up, after exclusion of people with an LVEF 50% at baseline [16]. A clinically relevant decrease in LVEF was defined as !10% reduction in LVEF between the two visits.…”