Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Oort, Sabine van; Beulens, Joline W.J.; Heijden, Amber A. W. A. van der; Elders, Petra; Stehouwer, Coen D. A.; Luitgaarden, Inge A. T. van de; Schrieks, Ilse C.; Grobbee, Diederick E.; Ballegooijen, Adriana J. van

doi:10.1016/j.numecd.2019.09.021

Cited by 8 publications

(7 citation statements)

References 26 publications

(36 reference statements)

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“…Excessive alcohol use during adolescence has been associated with reduced brain grey matter volumes (8), but evidence regarding structural brain changes at lower levels of alcohol intake is limited and conflicting (9)(10)(11). Moderate to heavy alcohol consumption is implicated causally with pathologically reduced left ventricular ejection fraction (12), cardiomyopathy, heart failure and sudden death. Analyses of cardiac structure based on echocardiography have suggested that smaller differences in left ventricular mass consistent with early pathology can also be attributed to lower levels of alcohol intake (13)(14)(15) Here, for the first time, we report associations across the range of population alcohol consumption with differences in morphology or function of multiple organs determined from quantitative measures of the brain, cardiac structure and function and liver fat Magnetic Resonance Imaging (MRI) scans.…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption in the general population is associated with structural changes in multiple organ systems

Εvangelou

Suzuki

Bai

et al. 2021

eLife

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Background: Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. Methods: We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta and liver of UK-Biobank participants who reported drinking alcohol. Results: We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7´10-3±0.76´10-3 per doubling of alcohol consumption, P=3.0´10-14). Alcohol consumption also was associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Conclusions: Our results imply that there is not a 'safe threshold' below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited. Funding: See acknowledgements

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Section: Introductionmentioning

confidence: 99%

Alcohol consumption in the general population is associated with structural changes in multiple organ systems

Εvangelou

Suzuki

Bai

et al. 2021

eLife

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Alcohol consumption is associated with structural changes in various organ systems: A population-based study in UK Biobank

Εvangelou

Suzuki

Bai

et al. 2021

Preprint

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Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. We assessed global effects of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta and liver of UK-Biobank participants who reported drinking alcohol. We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7×10−3±0.76×10−3 per doubling of alcohol consumption, P=3.0×10−14). Alcohol consumption also was associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Our results imply that there is not a “safe threshold” below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.

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“… 8–10 Similarly, the dimensions and mass of the left ventricle were found to be increased among drinkers in some studies 4 8–10 not in all. 6 LA dimensions and indices of diastolic dysfunction were increased among drinkers in some studies, 4 9 11 but not in others. 6 8 10 …”

Section: Discussionmentioning

confidence: 78%

“… 6 LA dimensions and indices of diastolic dysfunction were increased among drinkers in some studies, 4 9 11 but not in others. 6 8 10 …”

Section: Discussionmentioning

confidence: 78%

Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function

et al. 2021

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ObjectiveThe aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.Methods and resultsWe used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that recruited 2479 participants aged 35–69 years from the general population of the city of Arkhangelsk in Northwest Russia and 278 patients from the Arkhangelsk Regional Psychiatric Hospital with a primary diagnosis related to chronic alcohol use (narcology clinic subsample). The drinking patterns of the population-based sample were characterised in detail. We used regression models controlling for age, sex, smoking, education and waist to hip ratio to evaluate the differences in echocardiographic indices in participants with different drinking patterns. The means of left ventricular end-diastolic diameter and indexed left atrial systolic diameter were increased among heavy drinkers (narcology clinic subsample), while mean left ventricular ejection fraction was decreased in this group compared with the population-based sample. In contrast, the harmful and hazardous drinkers in the population-based sample did not differ from non-problem drinkers with respect to echocardiographic indices of systolic and diastolic function.ConclusionsExtremely heavy drinking is associated with a specific set of structural and functional abnormalities of the heart that may be regarded as precursors of alcohol-related dilated cardiomyopathy.

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Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Cited by 8 publications

References 26 publications

Alcohol consumption in the general population is associated with structural changes in multiple organ systems

Alcohol consumption in the general population is associated with structural changes in multiple organ systems

Alcohol consumption is associated with structural changes in various organ systems: A population-based study in UK Biobank

Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function

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