Association Between Advanced Age and Vascular Disease in Different Arterial Territories

Savji, Nazir; Rockman, Caron; Skolnick, Adam H.; Guo, Yu; Adelman, Mark A.; Riles, Thomas S.; Berger, Jeffrey S.

doi:10.1016/j.jacc.2013.01.054

Cited by 248 publications

(111 citation statements)

References 37 publications

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“…The sample also included a broad representation of socioeconomic status, as represented by participant zip-code (Shah et al, 2014). As we have published previously, the prevalence of different cardiovascular risk factors in this population database was similar to those of the general US adult population (Savji et al, 2013). Characteristics of the population by category of reported nut consumption frequency appear in Table 1.…”

Section: Resultssupporting

confidence: 84%

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Heffron

Rockman

Gianos

et al. 2015

Preventive Medicine

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Nut consumption has been associated with lower risk of coronary heart disease and all-cause mortality. The association between nut intake and peripheral arterial disease (PAD) is uncertain. Objective We sought to investigate the association between nut consumption and presence of prevalent PAD in a large cross-sectional sample. Methods Self-referred participants at >20,000 US sites who completed a medical and lifestyle questionnaire were evaluated by screening ankle brachial indices for PAD. Multivariable logistic regression analysis was used to estimate odds of PAD in different nut consumption categories. Results Among 3,312,403 individuals, mean age was 63.6 ±10.6 years and 62.8% were female. There were 219,527 cases of PAD. After multivariable adjustment there was an inverse association of nut intake with PAD. Compared to subjects with consumption of nuts

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Section: Resultssupporting

confidence: 84%

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Heffron

Rockman

Gianos

et al. 2015

Preventive Medicine

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“…One of the major differentiating features is that isolated valve patients do not have significant coronary artery disease, and additionally, we and others 21 found that they have a 10% to 20% lower likelihood of manifesting concomitant cerebrovascular or peripheral arterial disease. In fact, isolated valve patients 80 to 84 years had a similar prevalence of noncoronary vascular disease as CABG patients 75 to 79 years.…”

Section: Circ Cardiovasc Qual Outcomes July 2016mentioning

confidence: 62%

Derivation and Validation of Prognosis-Based Age Cutoffs to Define Elderly in Cardiac Surgery

Afilalo

Steele

Manning

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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Background-The age cutoff to define elderly is controversial in cardiac surgery, empirically ranging from ≥65 to ≥80 years. Beyond semantics, this has important implications as a starting point for clinical care pathways and inclusion in trials. We sought to characterize the relationship between age and adverse outcomes in patients undergoing cardiac surgery and to derive and validate prognosis-based age cutoffs. Methods and Results-Six thousand five hundred seventy one consecutive adult patients undergoing cardiac surgery at 3 hospitals in the United States and Canada were included in the cohort. Logistic regression models and generalized additive models with thin-plate splines were fit to the data. The age distribution was 50 to 59 years in 1244 (18.9%), 60 to 69 years in 2144 (32.6%), 70 to 79 years in 2000 (30.4%), ≥80 years in 1183 (18.0%) patients. After controlling for sex and type of operation, the relationship between age and 30-day operative mortality was found to be nonlinear. Receiver operating characteristic analysis showed that the optimal cutoffs to identify older patients at higher risk of operative mortality were greater than 74, 78, and 75 years for isolated coronary bypass, isolated valve surgery, and coronary bypass plus valve surgery, respectively. These age cutoffs were validated in an independent cohort. Conclusions-The relationship between age and operative mortality is not linear, manifesting a steeper rise after age 75 for coronary bypass and approaching octogenarian age for isolated valve surgery. Rather than using arbitrary age cutoffs to define elderly, the outcomes-based cutoff of ≥75 years should be used to identify the population of older adults that has higher risk and may benefit from preoperative geriatric evaluation and optimization. (Circ Cardiovasc Qual Outcomes. 2016;9:424-431.

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“…The cohort consisted primarily of individuals who self-paid for vascular screening tests from 2003 to 2008 in the tristate region (4), This region was chosen because of its large, heterogeneous population and wide variation in PM 2.5 exposure (6.7 to 14.7 μg/m 3 ). Prior to vascular ultrasound, participants completed demographic, smoking, medical comorbidity, cardiovascular risk factor, and family history questionnaires (4). CAS was assessed with bilateral carotid artery duplex ultrasound.…”

mentioning

confidence: 99%

Particulate Air Pollution and Carotid Artery Stenosis

Newman¹,

Thurston²,

Cromar³

et al. 2015

Journal of the American College of Cardiology

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Association Between Advanced Age and Vascular Disease in Different Arterial Territories

Abstract: There is a dramatic increase in the prevalence of PAD, CAS, and AAA with advanced age. More than 20% and 30% of octogenarians and nonagenarians, respectively, have vascular disease in at least 1 arterial territory.

Cited by 248 publications

References 37 publications

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Greater frequency of nut consumption is associated with lower prevalence of peripheral arterial disease

Derivation and Validation of Prognosis-Based Age Cutoffs to Define Elderly in Cardiac Surgery

Particulate Air Pollution and Carotid Artery Stenosis

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