Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis

Abstract

BackgroundVascular endothelial growth factor (VEGF) is thought to play an important role in the pathogenesis of diabetic retinopathy (DR). Previous studies have associated the VEGF rs2146323 polymorphism with the risk of DR. However, the results of these studies are inconsistent. A meta-analysis was performed to evaluate the association between the VEGF rs2146323 polymorphism and the risk of DR.MethodsThe PubMed, EMBASE, Web of Science and Google Scholar literature databases until March 2015 were searched. The differences in the studies were expressed in the form of an odds ratio (OR) and the corresponding 95 % confidence interval (CI). Heterogeneity among the studies was tested using the I2 statistic based on the Q test.ResultsA total of four studies (598 cases and 709 controls) were included in the meta-analysis. A significant association was found involving the rs2146323 polymorphism in the dominant model (CA + AA VS. CC) (OR = 1.38, CI = 1.10–1.72, P = 0.005) and the co-dominant model (CA VS. CC) (OR = 1.37, CI = 1.08–1.74, P = 0.008).ConclusionsOur meta-analysis confirmed the association between the VEGF rs2146323 polymorphism and the risk of DR.

Association between the vascular endothelial growth factor single nucleotide polymorphisms and diabetic retinopathy risk: A meta‐analysis

“…Furthermore, another VEGF SNP, namely rs2146323 (C > A), is located in exon 3, rather than the predicted transcription factor binding sites. A recent meta‐analysis implied that there was a significant association between the rs2146323 (C > A) polymorphism and the risk of DR . Thus, the present study could complement these previous findings.…”

The relationships between type 2 diabetic retinopathy and VEGF-634G/C and VEGF-460C/T polymorphisms in Han Chinese subjects

“…Thus, it is possible that the influence of polymorphism -634C/G of the VEGF gene on DR is relatively small and dependent on the ethnicity and Our results suggest that polymorphism − 460 C/T, in the promoter region of the VEGF gene, is correlated with the risk of developing NPDR, but not PDR. In China, Wang, Jin, and Zhang (2008) and Zheng (2007) have investigated genotypes at the VEGF-460C/T locus and discovered that polymorphism correlated with the development of DR, with the C allele indicating susceptibility to DR. In contrast to our findings, studies of individuals in the UK (Ray et al, 2004) and India (Paine et al, 2012) have concluded that polymorphism − 460C/T of the VEGF gene represents an independent risk factor for PDR, while Awata et al (2002) found no influence of this polymorphism.…”

Diabetic macular oedema: clinical risk factors and emerging genetic influences

“…Several meta‐analyses have been conducted in order to confirm significant associations. VEGFA polymorphisms analysed include −634G > C(rs2010963), +5092C/A (rs2146323), −2578C/A (rs699947), −460T/C (rs833061), +936C/T (rs3025039) and −1154G/A (rs1570360) …”