Association between the vascular endothelial growth factor single nucleotide polymorphisms and diabetic retinopathy risk: A meta‐analysis

Xiujing, Xie; Yang, Yunmei; Jiang, Jiahuan; Lu, Yuan-Qiang

doi:10.1111/1753-0407.12480

Cited by 30 publications

(27 citation statements)

References 39 publications

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“…Several meta‐analyses have been conducted in order to confirm significant associations. VEGFA polymorphisms analysed include −634G > C(rs2010963), +5092C/A (rs2146323), −2578C/A (rs699947), −460T/C (rs833061), +936C/T (rs3025039) and −1154G/A (rs1570360) …”

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

Diabetic macular oedema: clinical risk factors and emerging genetic influences

Liu

Craig

Burdon

2017

Clinical and Experimental Optometry

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Diabetic macular oedema is the major cause of visual impairment in type 1 and type 2 diabetes. As type 2 diabetes becomes more prevalent worldwide, the prevalence of diabetic macular oedema is also expected to rise. Current management of diabetic macular oedema is challenging, expensive and not optimal in a subset of patients. Therefore, it is important to increase our understanding of the risk factors involved and develop preventative strategies. While clinical risk factors for diabetic macular oedema have been identified, few studies have addressed potential genetic risk factors. Epidemiology and family studies suggest genetic influences are of importance. In this review, we summarise known clinical risk factors, as well as discuss the small number of genetic studies that have been performed for diabetic macular oedema.

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Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

Diabetic macular oedema: clinical risk factors and emerging genetic influences

Liu

Craig

Burdon

2017

Clinical and Experimental Optometry

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“…VEGF has been found to be the closest gene to SNP in DR-specific gene research [7] . SNP-634C is the most researchful loci.…”

Section: Discussionmentioning

confidence: 99%

Association Between the VEGF Gene Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis of 4216 Individuals

Hu¹,

Li²,

Qin³

et al. 2018

dtbh

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“…To determine whether VEGF SNPs are associated with the risk of DR, several meta-analyses have been performed, though the results varied. For example, the study by Xie et al [34] showed that the SNPs rs3025039 and rs833061 were most likely associated with an increased risk of DR. On the other hand, no significant association was found between VEGF 2578C/A polymorphism (rs699947) and DR risk, which was consistent with the results of Gong et al [35]. By contrast, the results from Wang et al [36] supported the association between VEGF 2578C/A polymorphism and the incidence of DR in Asian population, but not in Caucasian population.…”

Section: Association Of Vegf Gene Polymorphisms With Susceptibility Tmentioning

confidence: 99%

Association of VEGF Gene Polymorphisms with Susceptibility to Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Yang

Zhang

et al. 2020

Horm Metab Res

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The associations between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of type 2 diabetic retinopathy (DR) – proliferative diabetic retinopathy (PDR), and nonproliferative diabetic retinopathy (NPDR) – remain unclear. A systematic search and meta-analysis using odds ratio (OR) with 95% confidence interval (CI) was performed to evaluate the association. Our study concluded 26 studies containing 10 single nucleotide polymorphisms (SNPs). In Asian populations, rs3025039 polymorphism was associated with DR risk, while in overall populations and Caucasians, the DR risk was increased by association with rs2010963. There was a significant association between rs25648 and rs833061 and DR risk in Caucasians. DR risks were found to be significantly associated between rs3025021, rs13207351, and rs2146323 in either overall populations, Caucasians or Asians. Besides, in overall and Asian populations, rs699947 and rs3025039 were associated with PDR risk. rs1570360, rs3025039, and rs833061 played a key role in PDR etiology in Caucasians. rs2010963 was associated with increased risk of PDR in overall populations. A significant association between rs699947, rs3025039, and rs833061 and NPDR risk in overall populations and Asians was found. A significant association was observed between rs2010963 and increased NPDR risk in overall and Caucasian populations. This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR, and NPDR.

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Association between the vascular endothelial growth factor single nucleotide polymorphisms and diabetic retinopathy risk: A meta‐analysis

Abstract: Background The goal of the study was to reveal the relationship between vascular

Cited by 30 publications

References 39 publications

Diabetic macular oedema: clinical risk factors and emerging genetic influences

Diabetic macular oedema: clinical risk factors and emerging genetic influences

Association Between the VEGF Gene Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis of 4216 Individuals

Association of VEGF Gene Polymorphisms with Susceptibility to Diabetic Retinopathy: A Systematic Review and Meta-Analysis

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