Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients

Human food preferences are associated with a 5-HT2A serotonergic receptor polymorphism

“…Among the various components of the serotoninergic system, we studied a specific functional polymorphism of the of 5-HT receptor subtype, 5-HT 2A -T102C, which has been reported to be associated with eating disorders such as anorexia nervosa 5 and bulimia nervosa. 6 The T102C polymorphism is in linkage disequilibrium with the À1438G/A variant in the promoter region of the 5-HT 2A receptor gene. 7 We studied a sample of 240 subjects who were genotyped and had their diet patterns recorded for macro and micronutrients.…”

Olanzapine Reduces Physical Activity in Rats Exposed to Activity-Based Anorexia: Possible Implications for Treatment of Anorexia Nervosa?

“…Studies on the use of serotonin reuptake inhibitors (SSRIs) in malnourished AN patients showed no benefits of treatment (Kaye et al 1998); however, SSRIs seem to be effective in preventing relapse in recovered AN patients (Kaye et al 2001). Genetic association studies showed possible implications of polymorphisms in the 5-HT 2A receptor, 5-HT 2C receptor, and serotonin transporter in AN (Collier et al 1997;Di Bella et al 2000;Hu et al 2003;Nacmias et al 1999;Westberg et al 2002), although other studies could not confirm these findings (Ando et al 2001;Gorwood et al 2002;Hinney et al 1997;Nishiguchi et al 2001).…”

Genetic aspects of binge eating disorder Part 2. Molecular genetics and pharmacogenetic approaches

“…Пока-зан их протективный эффект на уровне тенденции для по-лиморфизма rs2296972 в гене серотонинового рецептора 5HT2A в отношении риска развития ВЕD у женщин моло-дого возраста [29]. При обследовании японской популя-ции [30] было установлено, что аллель G полиморфизма MspI (-1438A/G) в промоторном регионе гена 5HT2A ре-цептора увеличивает риск приступообразного переедания в рамках булимии и коморбидных пограничных психиче-ских расстройств. При этом ряд полиморфизмов в генах Журнал неврологии и психиатрии, 8,2016 генетика приступооБразного переедания 5-HT2A рецептора и BDNF обнаружил связь с анорексией [31].…”