Association between -308 G/A polymorphism in TNF-α gene and lichen planus: A meta-analysis

Jin, Xin; Wang, Jiayi; Zhu, Lili; Wang, Lili; Dan, Hongxia; Zeng, Xin; Chen, Qianming

doi:10.1016/j.jdermsci.2012.09.003

Cited by 32 publications

(29 citation statements)

References 34 publications

(67 reference statements)

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“…OLP is more common in middle aged women [7]. The genetic factors influencing immune function have been indicated to contribute to the OLP etiology [4, 8]. Cytokines play an important role in the progression/ pathogenesis of OLP and polymorphisms in cytokines genes such as IFN-γ, TNF-α, TNF-β, IL-4, IL-10 have been associated with the susceptibility of OLP [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility

et al. 2016

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BackgroundOral lichen planus (OLP) is a premalignant mucocutaneous disease in which genetic factors and immune responses play a major role. Cytokines play an important role in the pathogenesis and disease progression of OLP. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 and Th2 cytokines, interferon-gamma (IFN-γ), interleukin-6 (IL-6) and transforming growth factor (TGF)-β1 on OLP susceptibility in a Saudi cohort.MethodsForty two unrelated patients with OLP and 195 healthy controls were genotyped for IFN-γ (874A/T), IL-6 (174G/C) and TGF-β1 (509C/T) polymorphisms.ResultsThe frequency of genotype AT of IFN-γ (874A/T) was significantly higher while genotype AA was lower in OLP patients as compared to controls (P < 0.05). The frequency of T containing genotypes (AT + TT) was also higher in OLP patients as compared to that in controls (P = 0.003). The frequencies of allele T was higher while that of allele A lower in patients than the controls however the difference was not statistically significant (P = 0.07). There was no significant difference in the frequencies of alleles and genotypes of IL-6 (174G/C) and TGF-β1 (509C/T) polymorphisms between patient and control groups. These results indicated that genotype AT of IFN-γ (874A/T) polymorphism is associated with OLP risk and genotype AA is protective to OLP. On the other hand the polymorphisms IL-6 (174G/C) and TGF-β1 (509C/T) may not be associated with OLP risk in our population.ConclusionIt is concluded that IFN-γ (874A/T) polymorphism is associated with the susceptibility of OLP, however further studies with large sample size involving different ethnic populations should be conducted to strengthen our results.

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Section: Introductionmentioning

confidence: 99%

Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility

et al. 2016

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“…A meta-analysis demonstrated TNF-α gene-308A/G polymorphism was associated with decreased risk of psoriasis [52]. However, other meta-analysis suggested no association was found between this polymorphism and LP risk in combined analyses [53]. DM is a typical idiopathic skin disease, and the relationship between TNF-α-308A/G and DM was contradictory.…”

Section: Discussionmentioning

confidence: 99%

Associations between TNF-α-308A/G Polymorphism and Susceptibility with Dermatomyositis: A Meta-Analysis

Chen

Wang

et al. 2014

PLoS ONE

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BackgroundSome surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately.MethodsRelevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for the TNF-α-308A/G in the DM and control subjects was extracted and statistical analysis was conducted using STATA 11.2 software. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were used to calculate the risk of DM with TNF-α-308A/G. Stratified analysis based on ethnicity and control population source was also performed.Results555 patients with DM and 1005 controls from eight published investigations were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the TNF-α-308A allele were 2.041 (95% CIs 1.528–2.725, P<0.0001) in DM. Stratification by ethnicity indicated the TNF-α-308A allele polymorphism was found to be significantly associated with DM in Europeans (OR = 1.977, 95% CI 1.413–2.765, P<0.0001). The only study conducted on TNF-α-308A/G polymorphism in Asians could not be used in ethnicity-stratified meta-analysis. Meta-analysis of the AA+AG vs. GG (dominant model) and AA vs. GG (additive model) of this polymorphism revealed a significant association with DM in overall populations and Europeans.ConclusionsOur meta-analysis demonstrated that the TNF-α-308A/G polymorphism in the TNF gene might contribute to DM susceptibility, especially in European population. However, further studies with large sample sizes and among different ethnicity populations should be required to verify the association.

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“…T lymphocytes further inflammation through chemokine release and cause widespread keratinocyte apoptosis through direct ligand interaction or indirect cell signaling [55]. Additionally, evidence for a genetic predisposition to OLP has been found through the genetic analysis of the cell signaling proteins and cytokines of OLP patients [56,57].…”

Section: Oral Lichen Planus and Oral Lichenoid Lesionsmentioning

confidence: 99%

Mucosal Lesions in an Allergy Practice

Kohorst

Bruce

Torgerson

2016

Curr Allergy Asthma Rep

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The diagnosis and treatment of mucosal disease with an allergic pathogenesis are challenging. Oral allergy is often a hypersensitivity reaction with variable symptoms and physical exam findings. Clinical diagnosis requires a history of prior allergen exposure, a delay from exposure to clinical findings, and improvement following allergen removal. The past decades have seen great contributions to the field of oral allergy. The aim of this review is to provide an approach to the diagnosis and treatment of oral dermatologic disease with a focus on diseases with an investigated allergic pathogenesis.

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Association between -308 G/A polymorphism in TNF-α gene and lichen planus: A meta-analysis

Cited by 32 publications

References 34 publications

Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility

Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility

Associations between TNF-α-308A/G Polymorphism and Susceptibility with Dermatomyositis: A Meta-Analysis

Mucosal Lesions in an Allergy Practice

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