Association between 19 Allergens and Chronic Constipation in Adults: NHANES 2005–2006

Abstract

<b><i>Introduction:</i></b> There are increasing reports of a link between chronic constipation and allergies in children. However, similar epidemiological evidence is limited in the general adult population. Therefore, in this study, we attempted to assess the association between chronic constipation and allergy in adults aged ≥20 years in the USA. <b><i>Methods:</i></b> We established a logistic regression model to test the relationship between chronic constipation and 19 specific immunoglobulin E (sIgE) types in adults aged ≥20 years using large-sample data from the National Health and Nutrition Examination Survey database (2005–2006). The weekly defecation times of the allergic and non-allergic groups were compared using the <i>t</i> test. <b><i>Results:</i></b> We found that sIgE-sensitized participants had a 0.723 lower risk of chronic constipation than the general population (95% confidence interval (CI) = 0.566–0.923). There was a negative association between chronic constipation and sensitizations to peanut (odds ratio (OR) = 0.579, 95% CI = 0.381–0.935), egg (OR = 0.335, 95% CI = 0.134–0.838), dog (OR = 0.723, 95% CI = 0.522–0.965), and cockroach (OR = 0.540, 95% CI = 0.373–0.784). In addition, the frequency of defecation per week increased significantly in people allergic to peanuts and cockroaches (<i>p</i> < 0.05). <b><i>Discussion/Conclusion:</i></b> The results of this study demonstrate an inverse relationship between sIgE sensitization and chronic constipation in adults. However, the specific association mechanism needs to be further studied.

No Association Between Allergic Diseases and Constipation in Japanese Ulcerative Colitis Patients: A Cross-Sectional Study

“…Three Taiwanese cohort studies reported that constipation was a risk factor for allergic dermatitis [ 10 ], allergic rhinitis [ 11 ], and asthma [ 9 ]. On the other hand, in a US study, food allergies including peanut, eggs, and allergies to dogs and cockroaches are inversely associated with the prevalence of constipation [ 26 ].…”

Association between energy‐adjusted dietary inflammatory index and total immunoglobulin E: A cross‐sectional study

“…Serum samples were collected at the NHANES examination site and analyzed in the NHANES laboratory, and serum total IgE was tested using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, MI, USA) (Min & Min, 2019 ; Xi et al., 2023 ). Total IgE was analyzed as a continuous variable, while participants were categorized into two groups according to total IgE levels: normal total IgE levels (2.5–100 kU/L) and high total IgE levels (100–1000 kU/L), with the latter indicating total IgE sensitization (Ferastraoaru & Rosenstreich, 2018 ; Xi et al., 2023 ).…”

“…Considering that age, gender, race, BMI, alcohol consumption, smoking, diabetes, hypertension, and physical exercise may affect E‐DII and total IgE, these variables were included in multivariable models (Min & Min, 2019 ; Sun et al., 2023 ; Xi et al., 2023 ). Smoking, alcohol consumption, and physical exercise were determined based on responses to the relevant questions.…”