Association between 17q21 variants and asthma predisposition in Pashtun population from Pakistan

Afzal, Sibtain; Ramzan, Khushnooda; Ullah, Sajjad; Jamal, Arshad; Basit, Sulman; Alkattan, Khaled; Waqar, Ahmed Bilal

doi:10.1080/02770903.2021.2025391

Cited by 5 publications

(4 citation statements)

References 61 publications

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“…Over 100 genes have been associated with asthma and the features of the disease; however, there is marked variability in replication attempts in independent studies. Genetic variants on chromosome 17q21 near to ORMDL3/GSDMB locus have been associated with childhood-onset asthma ( Ntontsi et al, 2021 ; Afzal et al, 2023 ). Kumar et al highlighted the association between the variant rs1805011 in the IL-4 receptor gene and Th1/Th2 differentiation, which increases susceptibility to asthma ( Kumar et al, 2015 ).…”

Section: Microbiome and Asthma: The Importance Of The Beginningmentioning

confidence: 99%

“…Over 100 genes have been associated with asthma and the features of the disease; however, there is marked variability in replication attempts in independent studies. Genetic variants on chromosome 17q21 near to ORMDL3/GSDMB locus have been associated with childhood-onset asthma (Ntontsi et al, 2021;Afzal et al, 2023). Kumar et al highlighted the association between the The Gut-Lung Axis: A bidirectional communication network between the gastrointestinal tract and the respiratory system involving interactions among immune cells, neurons, microbiota, and signaling molecules.…”

Section: Genetics Factorsmentioning

confidence: 99%

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Winds of change a tale of: asthma and microbiome

Galeana-Cadena,

Gómez-García,

Lopez-Salinas

et al. 2023

Front. Microbiol.

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The role of the microbiome in asthma is highlighted, considering its influence on immune responses and its connection to alterations in asthmatic patients. In this context, we review the variables influencing asthma phenotypes from a microbiome perspective and provide insights into the microbiome’s role in asthma pathogenesis. Previous cohort studies in patients with asthma have shown that the presence of genera such as Bifidobacterium, Lactobacillus, Faecalibacterium, and Bacteroides in the gut microbiome has been associated with protection against the disease. While, the presence of other genera such as Haemophilus, Streptococcus, Staphylococcus, and Moraxella in the respiratory microbiome has been implicated in asthma pathogenesis, indicating a potential link between microbial dysbiosis and the development of asthma. Furthermore, respiratory infections have been demonstrated to impact the composition of the upper respiratory tract microbiota, increasing susceptibility to bacterial diseases and potentially triggering asthma exacerbations. By understanding the interplay between the microbiome and asthma, valuable insights into disease mechanisms can be gained, potentially leading to the development of novel therapeutic approaches.

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Section: Microbiome and Asthma: The Importance Of The Beginningmentioning

confidence: 99%

“…Over 100 genes have been associated with asthma and the features of the disease; however, there is marked variability in replication attempts in independent studies. Genetic variants on chromosome 17q21 near to ORMDL3/GSDMB locus have been associated with childhood-onset asthma (Ntontsi et al, 2021;Afzal et al, 2023). Kumar et al highlighted the association between the The Gut-Lung Axis: A bidirectional communication network between the gastrointestinal tract and the respiratory system involving interactions among immune cells, neurons, microbiota, and signaling molecules.…”

Section: Genetics Factorsmentioning

confidence: 99%

Winds of change a tale of: asthma and microbiome

Galeana-Cadena,

Gómez-García,

Lopez-Salinas

et al. 2023

Front. Microbiol.

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“…This led to the conclusion that the dysregulation of miR-126 relates to COPD susceptibility and acute exacerbation risk, but also is linked to severity and in ammatory cytokines in COPD patients 55 . compounding factors categorized as COPD [5][6][7][8][9] .…”

Section: Mirnamentioning

confidence: 99%

“…TGF-β regulates the respiratory system and can lead to diseases if it is mutated. Subduing altered TGF-β signaling in the airways and alveolar sacs via gene silencing technologies may provide similar therapeutic outcomes to modulator therapies and other treatment options 9 .…”

Section: Introductionmentioning

confidence: 99%

Gene Therapy Avenues for Chronic Obstructive Pulmonary Disease

Calendine¹,

Batra²,

Cherfils³

et al. 2022

bptjm

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Gene therapy is a growing field in research and development that may offer a long-lasting solution to several complex diseases, including chronic obstructive pulmonary disease (COPD). COPD is characterized by chronic inflammation in the lungs and the airways, leading to respiratory problems. COPD includes chronic bronchitis and emphysema. Optimizing treatments for gene therapy in COPD is of paramount importance given COPD's prominence as the fourth leading cause of disease-related death in the United States. We reviewed delivery methods in the current research, including liposomes, nanoparticles, electroporation, adeno-viruses, and adenoassociated viruses (AAV). The broad customizability in the diagnostic and treatment methods is evident in the recent studies. In this paper we explore each method and/or biomarker and evaluate several gene therapy avenues for COPD.

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