Association between -174G/C and -572G/C interleukin 6 gene polymorphisms and severe radiographic damage to the hands of Mexican patients with rheumatoid arthritis: a preliminary report

Abstract

ABSTRACT. Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JBA). The objective of the present study was to evaluate the association between severe radiographic damage in hands and the -174G/C and -572G/C IL6 polymorphisms in Mexican Mestizo people with RA. Mestizo adults with RA and long disease duration (>5 years) were classified into two groups according to the radiographic damage in their hands: a) severe radiographic damage (JBA and/or joint bone subluxations) and b) mild or moderate radiographic damage. We compared the differences in genotype and allele frequencies of -174G/C and -572G/C IL6 polymorphisms (genotyped using polymerase chain reaction-restriction fragment length polymorphism) between these two groups. Our findings indicated that the -174G/C polymorphism of IL6 is associated with severe joint radiographic damage [maximum likelihood odds ratios (MLE_OR): 8.03; 95%CI 1.22-187.06; P = 0.03], whereas the -572G/C polymorphism of IL6 exhibited no such association (MLE_OR: 1.5; 95%CI 0.52-4.5; P = 0.44). Higher anti-cyclic citrullinated peptide antibody levels were associated with more severe joint radiographic damage (P = 0.04). We conclude that there is a relevant association between the -174G/C IL6 polymorphism and severe radiographic damage. Future studies in other populations are required to confirm our findings.

The Association of Genetic Polymorphisms in Tumor Necrosis Factor-Alpha and Interleukins with Disease Severity or Response to Biological Therapy in Iraqi Rheumatoid Arthritis Patients: A Narrative Review

“…Locally acting on synoviocytes and osteoclasts in rheumatoid arthritis, IL-17A strengthens the connection between synoviocytes and joint deterioration [44]. In RA patients, IL-17 expression was found to be increased by Mahmood et al The study also divided the patients into groups based on the amounts of DAS-28 and ACCP antibodies in their bodies.…”

Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

“…Different studies have examined the effect of IL-6 SNP and/or IL-8 SNP on diseases' risk, activity, and progression. Results showed marked ethnicity-associated disparities and diverse findings [12,[16][17][18][19][20][21][22][23]. For instance, a meta-analysis of European and Asian studies on IL-6 SNP and rheumatoid arthritis (RA) risk showed that IL-6 SNP was significantly associated with RA in Asian patients but not in the Caucasian population [20].…”

“…For instance, a meta-analysis of European and Asian studies on IL-6 SNP and rheumatoid arthritis (RA) risk showed that IL-6 SNP was significantly associated with RA in Asian patients but not in the Caucasian population [ 20 ]. Another study has reported a strong association between IL-6 SNP and hand joint damage among Mexican patients [ 19 ]. In addition, vitamin D receptor (VDR) rs7975232 SNP was reported to predict PCa risk in African American men [ 23 ].…”

Gene expression and six single nucleotide polymorphisms of interleukin-6 in rheumatoid arthritis: A case-control study in Iraqi patients

“…13 Another IL6 SNP (IL6 -572 : G/C) has also been investigated and its association with RA susceptibility or severity has been suggested in patients of different ethnicities. 14,15 The AG genotype of IL6 rs184229712 SNP was observed to be significantly associated with an increased expression of IL6 gene compared to GG genotype; therefore, it is suggested that such SNP may influence the gene expression of IL6 and subsequently its serum level in RA patients. The IL6 -174 and IL6 -572 SNPs have also been suggested to exert an influence on the transcription rate of IL-6 protein, and may influence IL-6 serum level in RA patients.…”

“…14 Additional findings indicated that IL6 -174 SNP is associated with severe joint radiographic damage, while IL6 -572 showed no such association. 15 Accordingly, this study was conducted to assess gene expression and six SNPs (rs1800796 C/G, rs7802307 A/C/T, rs7802308 A/T, rs36215814 A/G, rs184229712 A/G and rs867254801 C/G) of IL-6 in etanercept-treated RA Iraqi Arab patients, with some emphases on disease activity, as well as clinical and laboratory markers of disease.…”