Association Between −1562C&gt;T Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 and Coronary Artery Disease: A Meta-Analysis

Zhang, Fengxiang; Sun, Dapeng; Guan, Ning; Chen, Jun-Jiang; Huo, Xiaochuan; Luo, Jun

doi:10.1089/gtmb.2013.0369

Cited by 13 publications

(9 citation statements)

References 44 publications

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“…Alp et al (2009) and Ghaderian et al (2010) did not find a significant association between MMP-9 rs3918242 genetic variation and development of coronary artery disease and myocardial infarction in Turkish and Chinese population. Two recent meta-analysis studies reported that the MMP-9 rs3918242 genetic factors may have association with the risk of coronary artery disease in Asian populations (Wang and Shi, 2014;Zhang et al, 2014). In our study, we found that the TT and CT genotypes and T allele of MMP-9 rs3918242 could influence the development of coronary artery disease in a Chinese population.…”

Section: Discussionsupporting

confidence: 61%

“…Three main polymorphisms were observed in the promoter, coding and untranslated region of MMP-9 (Zhang et al, 1999). The MMP-9 rs3918242 polymorphism (C ® T) is located at the promoter region, and previous studies have reported that the MMP-9 rs3918242 gene polymorphism plays an important role in the development of coronary artery diseases, but the results are inconclusive (Mishra et al, 2012;Opstad et al, 2013;Xu et al, 2013;Opstad et al, 2014;Wang and Shi, 2014;Zhang et al, 2014). Therefore, we carried out a case-control study to assess the role of one single nucleotide polymorphism (SNP) of MMP-9 rs3918242 in the development of coronary artery disease.…”

Section: Introductionmentioning

confidence: 98%

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Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

Qin¹,

Qin²,

Shi³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had higher systolic and diastolic blood pressure, as well as higher triglycerides (P < 0.05), were more likely to suffer from diabetes mellitus, and had lower total cholesterol and high-density lipopolysaccharides. Using unconditional logistic analysis, we found that individuals with CT and TT genotypes were associated with increased risk of coronary artery disease in a co-dominant model, and the ORs (95%CI) were 1.50 (1.02-2.20) and 6.89 (2.51-23.41) for CT and TT, respectively. We observed that the T allele of rs3918242 was correlated with increased risk of coronary artery disease (OR = 1.88, 95%CI = 1.39-2.55). In conclusion, we suggest that the TT and CT genotypes and T allele of MMP-9 rs3918242 polymorphism is correlated with an increased risk of coronary artery disease in a Chinese population

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 98%

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

Qin¹,

Qin²,

Shi³

et al. 2016

Genet. Mol. Res.

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show abstract

“…Zhang et al in the 214 meta-analysis, by including 26 studies containing 12,776 cases and 6371 controls, indicated that MMP-9 (C1562T) polymorphism was not associated with the risk of CAD in the overall results [69]. However, they reported that MMP-9 (C1562T) SNP is involved in the decrease susceptibility to CAD in Asian population.…”

Section: Discussionmentioning

confidence: 99%

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

Hassanzadeh-Makoui

Razi

Aslani

et al. 2020

BMC Cardiovasc Disord

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Background: We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). Methods: After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association. Results: We identified 40 studies with 11,792 cases and 8280 controls for C1562T, 7 case-control studies with 5525 cases and 2497 controls for R279Q, 2 studies with 1272 cases and 785 controls for P574R, and 2 studies with 1272 cases and 785 controls for R668Q. MMP-9 (C1562T) polymorphism was associated with increased risk of CAD under dominant model (OR = 1.41, P < 0.001), recessive model (OR = 1.59, P < 0.001), allelic model (OR = 1.38, P < 0.001), TT vs. CC model (OR = 1.70, P < 0.001), and CT vs. CC model (OR = 1.35, P < 0.001). Moreover, the subgroup analysis based on the continent of the study populations in this SNP indicated strong significant association in Asians but not in Europeans. Subgroup analysis was not performed in Africa, America and Oceania, due to lack of sufficient data. Conclusions: Our meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population. The overall analysis and subgroup analysis of the other three SNPs reject the association between MMP-9 polymorphisms and the risk of CAD. Although the results should interpret with caution because of small sample size of included studies in these three SNPs.

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“…Higher BNP level represents worse heart disease patient prognosis [ 15 ]. ET-1 level slightly increases when the cardiovascular load significantly increases in healthy persons; under pathological condition of ventricular wall overload, it clearly up-regulates and leads to myocardial fibrosis, vasospasm, and smooth muscle cell apoptosis or cracking [ 15 ]. MMP - 9 is involved in inflammation, angiogenesis, and extracellular matrix destruction, and leads to plaque production and rupture.…”

Section: Discussionmentioning

confidence: 99%

Plasma Brain Natriuretic Peptide, Endothelin-1, and Matrix Metalloproteinase 9 Expression and Significance in Type 2 Diabetes Mellitus Patients with Ischemic Heart Disease

Mei-xin

2015

Med Sci Monit

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BackgroundType 2 diabetes (DMT2) combined with ischemic heart disease (IHD) promotes the occurrence and development of coronary atherosclerosis. We aimed to provide a theoretical basis for improving patient prognosis through analyzing expression of plasma brain natriuretic peptide (BNP), endothelin-1 (ET 1), and matrix metalloproteinase 9 (MMP-9).Material/MethodsEnzyme-linked immunosorbent assay (ELISA) was used to detect BNP, ET-1, and MMP-9 levels in 50 patients with DMT2 only (group A), 47 patients with IHD only (group B), 43 patients with comorbid (both) IHD and DMT2 (group C), and 50 health controls (group D). Group C was further divided into single-branch lesion group, double-branch lesions group, and triple-branch lesion group according to coronary angiography, or cardiac function grade II, III, and IV group according to cardiac function, and their BNP, ET-1, and MMP-9 levels were compared.ResultsCompared with group D, TG, diastolic, and systolic blood pressure were all significantly elevated in groups A, B, and C. Group C exhibited obviously higher glycosylated hemoglobin than group A. Gensini score in group C was markedly higher than in group B. Compared with group D, BNP, ET-1, and MMP-9 levels were all increased in groups A, B, and C. Group C showed higher levels of BNP, ET-1, and MMP-9 than group A and B. BNP, ET-1, and MMP-9 levels in the triple-branch lesions group were higher than in the single-branch lesions group and double-branch lesions group. The cardiac function grade IV group presented higher levels of BNP, ET-1, and MMP-9 than did the grade II and III groups. BNP, ET-1, and MMP-9 showed a positive correlation to each other.ConclusionsBNP, ET-1, and MMP-9 may participate in the occurrence and development of comorbid DMT2 and IHD. They are important objective indicators for evaluating severity and prognosis of patients with comorbid DMA2 and IHD.

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Association Between −1562C>T Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 and Coronary Artery Disease: A Meta-Analysis

Abstract: Our meta-analysis supports the fact that -1562C>T polymorphism may have association with CAD risk in Asian populations. But further larger studies are required to confirm our findings.

Cited by 13 publications

References 44 publications

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis

Plasma Brain Natriuretic Peptide, Endothelin-1, and Matrix Metalloproteinase 9 Expression and Significance in Type 2 Diabetes Mellitus Patients with Ischemic Heart Disease

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