Association analysis of β2 adrenoceptor polymorphisms with hypertension in a Black African population

Abstract

These data suggest that beta2AR polymorphism is not a risk factor for hypertension per se in this defined population. The possibility that the decreased prevalence of Glu27 in black South African populations explains blunted vasodilator responses to isoprenaline requires further study.

Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis

“…The allelic frequencies of two SNPs (rs1042713 and rs1042714) in the current Omani cohort were compared with those of various ethnic groups reported in the literature [ Table 5]. 9,10,[15][16][17][18][19][20][21] Gly16 and Gln27 polymorphisms occur with high allelic frequency in Caucasian populations; 7,8 the frequencies of Gly16 and Gln27 polymorphisms in the current Omani cohort were similar. However, regardless of population, the frequency of the Gln27 variant showed higher inter-ethnic variation than the Gly16 variant (standard deviation: 0.14 versus 0.07).…”

Association study of the 5-HT2A receptor gene polymorphism, T102C and essential hypertension

“…[22][23][24][25] Furthermore, the ␤-2 adrenergic receptor has been implicated in the pathogenesis of hypertension due to the ␤-2 mediated vasodilatation and a significant association was identified between variants in the ␤-2 adrenergic receptor gene and hypertension. 26,27 Finally, the T-58C promoter polymorphism of the ␤-2 bradykinin receptor gene was associated with essential hypertension in a Japanese population. 28 Replication studies however, have not verified these associations and the question as to which genes are pathogenetically involved in hypertension remains.…”

Why is plasma renin activity lower in populations of African origin?

“…The Gly 16 Arg polymorphism is of particular interest as the Gly16 variant is associated with an attenuated vasodilatory response to catecholamines. 43 The frequency of this variant is markedly lower in blacks 44,45 but whether the presence of this variant is associated with differences in PRA remains to be seen.…”