Association study of the 5-HT2A receptor gene polymorphism, T102C and essential hypertension

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

“…Hypertension can be caused in rodents by deletion of genes encoding G protein-coupled receptors (GPCRs) that normally decrease blood pressure (3,4), or by overproduction of GPCR agonists that elevate blood pressure (5,6). Increased risk of hypertension in certain human populations has been associated with genetic polymorphisms in genes encoding components of GPCR signaling pathways (7)(8)(9)(10)(11)(12)(13).…”

The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years

“…Other studies on this gene polymorphism have used univariate analyses only (15,17), or alternatively have been multivariate studies on a smaller number of factors than the present study (16). We therefore consider that the design of our study would have resulted in improved epidemiological accuracy.…”

“…In contrast, we did not detect a significant relationship with hypertension in our study, possibly as a consequence of ethnic differences between the study cohorts. It should also be noted that the participants enrolled in the studies of both Choi et al (16) and Liolitsa et al (15) were hospital patients. From an epidemiological point of view, such a sampling method may have resulted in significant selection bias, and preferably both case and control subjects should be enrolled randomly from the general population.…”

“…As previous studies have reported that the 102C allele and -1438G are in genetic linkage (18,19), their result was equivalent to the -1438G allele being related to lower HDL-C levels, a finding directly opposite to our results. With regards to hypertension, Liolitsa et al (15) investigated 342 hypertensive subjects aged >75 years and 319 community-based control subjects group living in the UK and found that the 102C allele was more frequent in hypertensive female subjects. In contrast, we did not detect a significant relationship with hypertension in our study, possibly as a consequence of ethnic differences between the study cohorts.…”

“…In addition to psychiatric disorders, several clinical studies using the HTR2A selective antagonists, ketanserin and sarpogrelate (14), have shown the HTR2A is also implicated in the pathogenesis of a wide variety of cardiovascular diseases. Recent studies have also reported associations between variants in HTR2A and physical diseases with the 102T/C polymorphism being related to hypertension (15), decreased high-density lipoprotein cholesterol (HDL-C) (16) and irritable bowel syndrome (17). As the -1438A/G polymorphism is in complete linkage disequilibrium with T102C (18,19), it is considered a possible candidate for pathogenic polymorphisms.…”