Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive–compulsive or self-stimulatory behaviors

Sakurai, Takeshi; Ramoz, Nicolás; Reichert, Jennifer; Corwin, Thomas; Kryzak, Lauren A.; Smith, Christopher J.; Silverman, Jeremy M.; Hollander, Eric; Buxbaum, Joseph D.

doi:10.1097/01.ypg.0000242196.81891.c9

Cited by 58 publications

(33 citation statements)

References 40 publications

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“…The pervasive nature of the neurological effects of autism means that the presence of compulsive behaviors could well reflect a compromised reward system in some individuals. However, recent attempts to detect a genetic link between autism and defects in the reward circuit by examining the NrCAM gene failed to show any clear association (Sakurai et al, 2006). These data further increase the likelihood that a relatively unimpaired capacity to appreciate music will be characteristic of individuals with autism.…”

Section: Musical Cognition In Autismmentioning

confidence: 82%

Autism, Music, and the Therapeutic Potential of Music in Alexithymia

Allen

Heaton

2010

Music Perception

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IT HAS BEEN ARGUED, IN VIEW OF THE SOCIALevolutionary origins of music and the social deficits found in autism, that individuals with autism will be emotionally unresponsive to music. However, a recent study of high-functioning adults with autism has shown that they appear to have a range of responses to music similar to typically developing people, including the deliberate use of music for mood management. In examining why these responses appear unaffected in autism, we explore possible mechanisms for musical mood induction in listeners, hypothesizing that the simulation theory of empathy may illuminate current controversies over the nature of emotion in music. Drawing on these ideas, we put forward suggestions for using a simple associative learning process between musically induced emotions and their cognitive correlates for the clinical treatment of alexithymia, a disorder that is common in autism and characterized by an absence of cognitive insight into one's emotions.

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Section: Musical Cognition In Autismmentioning

confidence: 82%

Autism, Music, and the Therapeutic Potential of Music in Alexithymia

Allen

Heaton

2010

Music Perception

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“…[133] The literature on the neurobiology of stereotypic behaviors in developmental disabilities suggests some overlap with OCD [134,135] or some value in using comorbid obsessive-compulsive symptoms, as a specifier when studying these disorders. [136][137][138] Nevertheless, not all data confirm such overlap, [139][140][141] and the literature also points to a number of unique features of stereotypic symptoms in developmental disorders, including pathology in the peripheral neuronal system. [142,143] As reviewed above, the neurobiology of TTM and skin picking is similarly inconsistent as regards its relationship to OCD.…”

Section: Stereotypic Movement Disordermentioning

confidence: 89%

Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V

et al. 2010

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In DSM-IV-TR, trichotillomania (TTM) is classified as an impulse control disorder (not classified elsewhere), skin picking lacks its own diagnostic category (but might be diagnosed as an impulse control disorder not otherwise specified), and stereotypic movement disorder is classified as a disorder usually first diagnosed in infancy, childhood, or adolescence. ICD-10 classifies TTM as a habit and impulse disorder, and includes stereotyped movement disorders in a section on other behavioral and emotional disorders with onset usually occurring in childhood and adolescence. This article provides a focused review of nosological issues relevant to DSM-V, given recent empirical findings. This review presents a number of options and preliminary recommendations to be considered for DSM-V: (1) Although TTM fits optimally into a category of body-focused repetitive behavioral disorders, in a nosology comprised of relatively few major categories it fits best within a category of motoric obsessive-compulsive spectrum disorders, (2) available evidence does not support continuing to include (current) diagnostic criteria B and C for TTM in DSM-V, (3) the text for TTM should be updated to describe subtypes and forms of hair pulling, (4) there are persuasive reasons for referring to TTM as "hair pulling disorder (trichotillomania)," (5) diagnostic criteria for skin picking disorder should be included in DSM-V or in DSM-Vs Appendix of Criteria Sets Provided for Further Study, and (6) the diagnostic criteria for stereotypic movement disorder should be clarified and simplified, bringing them in line with those for hair pulling and skin picking disorder.

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“…This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. Of the candidate biological pathways for SCZ, the CAM pathways have repeatedly been linked to both psychosis and neurocognitive dysfunctions (14)(15)(16). In their study, Zhang et al (17) investigated the association between CAM pathways and SCZ in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

Family-Based Whole-Exome Sequencing for Identifying Novel Variants in Consanguineous Families with Schizophrenia

Shirzad

Beiraghi

Kachoui

et al. 2016

Iran Red Crescent Med J

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Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive–compulsive or self-stimulatory behaviors

Abstract: Overtransmission of particular haplotypes of NrCAM, that may relate to the expression level of NrCAM in the brain, appeared to be associated with autism in the severe obsessive-compulsive behavior subset.

Cited by 58 publications

References 40 publications

Autism, Music, and the Therapeutic Potential of Music in Alexithymia

Autism, Music, and the Therapeutic Potential of Music in Alexithymia

Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V

Family-Based Whole-Exome Sequencing for Identifying Novel Variants in Consanguineous Families with Schizophrenia

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