Association analysis of polymorphisms in caprine KiSS1 gene with reproductive traits

Maitra, A.; Sharma, Rekha; Ahlawat, Sonika; Tantia, M. S.; Roy, Manoranjan; Prakash, Ved

doi:10.1016/j.anireprosci.2014.09.013

Cited by 24 publications

(27 citation statements)

References 26 publications

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“…Few studies have reported an effect of doe breed or breed cross on LSK (Meza-Herrera et al, 2014). There is an interest in exploiting possible genetic differences in prolificacy to enhance meat goat productivity (Maitra et al, 2014;El-Tarabany et al, 2017). However, the current study along with the majority of others in the literature suggests that breed differences for this trait are not common.…”

Section: Litter Characteristics At Parturitionmentioning

confidence: 69%

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Khanal

Leite-Browning

Browning

2018

Journal of Animal Science

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Understanding fitness level among various breeds is essential for sustainable meat goat production. Research on the relative fitness of Boer F 1 does and straightbred base breed has been limited. Meat goat does of various genotypes (Boer, Kiko, Spanish, Boer × Kiko reciprocal F 1 crosses, and Boer × Spanish reciprocal F 1 crosses) were studied to evaluate breed effects on doe fitness traits and the expression of heterosis over 7 production years. The herd was semi-intensively managed under humid subtropical pasture. Doe age affected (P < 0.05) various traits. Boer × Kiko does were heavier (P < 0.05) than Boer does at fall breeding, but Boer × Spanish does did not differ (P > 0.05) from Boer does for breeding weight. The body weights of Boer × Spanish and Boer × Kiko crosses did not differ (P > 0.05) from the weights of their respective Kiko and Spanish base cohorts at breeding, kidding, or weaning. Boer does had lower (P < 0.05) kidding rate (KR) and weaning rate (WR) than the other breeds and crosses. Boer × Kiko and Kiko were similar for KR and WR. Boer × Spanish and Spanish were also similar for KR and WR. However, the combined group of Boer F 1 does had lower (P < 0.01) KR and WR than the combined purebred biotype group of Kiko and Spanish does. Boer does weaned smaller (P < 0.05) litter sizes per doe exposed compared with Kiko, Spanish, Boer × Kiko, and Boer × Spanish does with the latter four doe breedtypes not differing from each other. The combined Boer F 1 doe group weaned smaller (P < 0.05) litter sizes per doe exposed than the combined purebred group of Kiko and Spanish does. Boer × Kiko dams had higher (P < 0.05) fecal egg counts at parturition than Kiko dams. Significant heterosis was observed for reproductive traits within each of the 2-breed diallels. Boer F 1 does exhibited reproductive output similar to or lower than Kiko and Spanish straightbred does and higher than Boer straightbred does.

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Section: Litter Characteristics At Parturitionmentioning

confidence: 69%

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Khanal

Leite-Browning

Browning

2018

Journal of Animal Science

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“…Dijelaskan bahwa kisspeptin berperan penting dalam pematangan dan fungsi reproduksi, mulai dari diferensiasi seksual otak dan awal pubertas hingga pengaturan sekresi gonadotropin dan pengendalian metabolisme fertilitas pada ternak dewasa sehingga gen KISS1 berperan penting dalam reproduksi ternak. Menurut Maitra et al (2014) KISS1 dianggap sebagai mediator kunci dalam mekanisme molekuler reproduksi (pubertas dan prolifikasi) pada mamalia. Gahete et al (2016) menyatakan bahwa kisspeptin dapat mengendalikan secara spesifik, tipe sel serta status perkembangan yang bergantung pada sekresi hormonal dari kelenjar pituitari.…”

Section: Pendahuluanunclassified

“…MwoI (M = marker 100 bp, line 23= genotipe TT dengan panjang 110 dan 267 pb, line 45= genotipe AT dengan panjang 110, 267, dan 377 pb, line 67= genotipe AA dengan panjang 377 pb).bertanggung jawab dalam menentukan litter size di samping genotipe gen KISS1 (intron 1). Hal ini bersesuaian dengan laporanMaitra et al (2014) bahwa mutasi pada posisi g.296G<C, g.455T<G, g.505T<A, g.693T<C, g.950T<C pada gen KISS1 (intron 1) tidak berkaitan dengan litter size pada kambing Black Bengal. Hal yang sebaliknya dilaporkan El-Tarabany et al (2017) bahwa substitusi T dengan A pada posisi 121 (g.121T<A) ditemukan pada gen KISS1 (intron 1) pada kambing perah Baladi, Damaskus dan Zaribi.…”

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Association of BMP15, BMPR1B, and KISS1 Genes with Fecundity Traits on Etawah-Grade does

Mulyono

Sumantri

Noor

et al. 2019

JIPI

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ABSTRAK Kambing Peranakan Etawah (PE) merupakan hasil grading-up antara kambing Kacang dan kambing Etawah yang telah beradaptasi baik dengan lingkungan tropis lembap Indonesia. Kambing Peranakan Etawah (PE) merupakan kambing tipe dwiguna penghasil susu dan daging. Tujuan dari penelitian ini adalah untuk mengevaluasi polimorfisme gen fekunditas melalui pengamatan empat gen kandidat untuk prolifikasi, yaitu gen BMP15 (exon 1), BMPR1B (exon 1), KISS1 (exon 1), dan KISS1 (intron 1) dan hubungannya dengan litter size pada kambing PE betina induk. Keragaman gen BMP15 (exon 1), BMPR1B (exon 1), KISS1 (exon 1), dan KISS1 (intron 1) dianalisis dengan teknik PCR-RFLP. Sampel DNA yang digunakan sebanyak 106 ekor kambing PE betina induk di BPTU-HPT Pelaihari di Pelaihari, Kalimantan Selatan (51 ekor) dan di Peternakan Cordero di Bogor, Jawa Barat (55 ekor). Analisis variasi peringkat satu faktor Kruskal-Wallis digunakan untuk menentukan apakah ada pengaruh genotipe gen fekunditas pada litter size. Data keragaman genetik antara kelompok kambing PE betina induk dihitung dengan pendekatan frekuensi alel dan genotipe, serta Polymorphic Informative Content (PIC). Hasil keragaman genetik kambing PE berdasarkan nilai PIC diperoleh di BPTU-HPT Pelaihari sebesar 0,313, sedangkan di Peternakan Cordero adalah 0,144 dengan nilai PIC total sebesar 0,244. Hasil analisis Kruskal-Wallis menunjukkan bahwa tidak ditemukan pengaruh genotipe gen BMP15 (exon 1), BMPR1B (exon 1), KISS1 (exon 1), dan KISS1 (intron 1) pada litter size. Hasil penelitian menunjukkan bahwa lokus BMP15 (exon 1) dan KISS1 (exon 1) bersifat monomorfik, tetapi ditemukan dua lokus yang polimorfisme, yaitu lokus BMPR1B (exon 1) yang memiliki dua genotipe dengan frekuensi CC (96,23%), GG (3,77%), dan lokus KISS1 (intron 1) yang memiliki tiga genotipe dengan masing-masing frekuensi TT (80,19%), AT (17,92%), dan AA (1,89%).

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“…The breed, SNPs type and the position along the reference sequence and chromosome position are presented in Table 2. Several similar studies on KiSS-1 (intron 1) gene have identified several polymorphism in different goat populations (Cao et al, 2010;An et al, 2013b;Maitra et al, 2014a;El-Tarabany et al, 2017). Although these studies are focused on the non-coding regions of the gene it has been proven that mutations in intragenic (intron) regions may be involved in alternative splicing/regulation, transcript processing, gene expression and protein function, chromosomal rearrangement (Guey-Shin and Thomas, 2007;Sjakste et al, 2011) of varying phenotypes and have been found to affect economic traits (Jiang et al, 2010;Ibeagha-Awemu et al, 2014).…”

Section: Resultsmentioning

confidence: 94%

Sequencing, polymorphism and phylogenetic characterisation of KiSS-1 gene in two Nigerian indigenous goat breeds

et al. 2020

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KiSS-1 gene encodes a protein product kisspeptin which are intense inducers of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in various mammalian species through its receptor GPR54 (G protein-coupled receptor-54). A total of 100 goat compromising of Red Sokoto (n = 72) and Sahel (n = 28) breeds were used to detect single nucleotide polymorphisms (SNPs) in the intronic region of the KiSS-1 gene by sequencing and investigate their relationship with other goat breeds. Nucleotide sequence analysis revealed five novel SNPs (g.1745G>A present in Red Sokoto, g.1776G>A, g.1827A>G, g.1857T>C and g.2208T>C present in Red Sokoto and Sahel breeds). To obtain a correct phylogenetic relationship between goat breeds, nucleotide sequences were compared to other sequences in NCBI database using a BLASTn algorithm and retrieved for further analysis. Neighbour-joining phylogenetic relationship tree constructed revealed two distinct clusters with ancestral lineage of 100% identity. Nigerian goat breeds (Red Sokoto and Sahel) clustered into a clade with Indian goat breeds (Ganjam and Osmanabadi) while the second cluster involved eight other goat breeds. Genetic distance estimate revealed high genetic similarity between Red Sokoto and Sahel breeds as observed in their genetic distance value of 0.003. The nucleotide sequences of the two Nigerian goat breeds (Red Sokoto and Sahel) for KiSS-1 gene were submitted to GenBank database and have accession numbers: MN122316 and MN122317, respectively. The analysis of polymorphism in KiSS-1 gene indicates that genetic variation exists in the goat breeds studied. Therefore, attempts can be made to investigate the association of these polymorphism with reproductive traits in Nigerian goat breeds.

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Association analysis of polymorphisms in caprine KiSS1 gene with reproductive traits

Cited by 24 publications

References 26 publications

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Association of BMP15, BMPR1B, and KISS1 Genes with Fecundity Traits on Etawah-Grade does

Sequencing, polymorphism and phylogenetic characterisation of KiSS-1 gene in two Nigerian indigenous goat breeds

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