Association analysis of polymorphism in KiSS1 gene with reproductive traits in goats

Zaglool, Asmaa W.; El-Tarabany, Akram A.; Awad, Ashraf

doi:10.1016/j.anireprosci.2017.03.006

Cited by 21 publications

(31 citation statements)

References 51 publications

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“…Few studies have reported an effect of doe breed or breed cross on LSK (Meza-Herrera et al, 2014). There is an interest in exploiting possible genetic differences in prolificacy to enhance meat goat productivity (Maitra et al, 2014;El-Tarabany et al, 2017). However, the current study along with the majority of others in the literature suggests that breed differences for this trait are not common.…”

Section: Litter Characteristics At Parturitionmentioning

confidence: 70%

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Khanal

Leite-Browning

Browning

2018

Journal of Animal Science

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Understanding fitness level among various breeds is essential for sustainable meat goat production. Research on the relative fitness of Boer F 1 does and straightbred base breed has been limited. Meat goat does of various genotypes (Boer, Kiko, Spanish, Boer × Kiko reciprocal F 1 crosses, and Boer × Spanish reciprocal F 1 crosses) were studied to evaluate breed effects on doe fitness traits and the expression of heterosis over 7 production years. The herd was semi-intensively managed under humid subtropical pasture. Doe age affected (P < 0.05) various traits. Boer × Kiko does were heavier (P < 0.05) than Boer does at fall breeding, but Boer × Spanish does did not differ (P > 0.05) from Boer does for breeding weight. The body weights of Boer × Spanish and Boer × Kiko crosses did not differ (P > 0.05) from the weights of their respective Kiko and Spanish base cohorts at breeding, kidding, or weaning. Boer does had lower (P < 0.05) kidding rate (KR) and weaning rate (WR) than the other breeds and crosses. Boer × Kiko and Kiko were similar for KR and WR. Boer × Spanish and Spanish were also similar for KR and WR. However, the combined group of Boer F 1 does had lower (P < 0.01) KR and WR than the combined purebred biotype group of Kiko and Spanish does. Boer does weaned smaller (P < 0.05) litter sizes per doe exposed compared with Kiko, Spanish, Boer × Kiko, and Boer × Spanish does with the latter four doe breedtypes not differing from each other. The combined Boer F 1 doe group weaned smaller (P < 0.05) litter sizes per doe exposed than the combined purebred group of Kiko and Spanish does. Boer × Kiko dams had higher (P < 0.05) fecal egg counts at parturition than Kiko dams. Significant heterosis was observed for reproductive traits within each of the 2-breed diallels. Boer F 1 does exhibited reproductive output similar to or lower than Kiko and Spanish straightbred does and higher than Boer straightbred does.

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Section: Litter Characteristics At Parturitionmentioning

confidence: 70%

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Khanal

Leite-Browning

Browning

2018

Journal of Animal Science

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“…Genotyping of the SNP T125A of KiSS1 Gene by PCR-RFLP, number 1: TT genotype; number 2, 4 and 5: TA genotype; number 3: AA genotype subpopulations that do not completely interbred (Graffelman et.al., 2017). In the previous study El- Tarabany et al (2017) reported SNP T121A in Damascus, Zaribi, and Baladi goats having linked to reproductive trait including hormonal profile and litter size. Two genotypes (TA and TT) were identified.…”

Section: Genotyping and Allele Distributionmentioning

confidence: 99%

“…However, no information is available regarding the KiSS1 polymorphism in Indonesian local goats, especially Kaligesing goats to date. Significant association between polymorphisms of the KiSS1 gene and 17β-estradiol and progesterone has been reported in Baladi, Damascus and Zaribi goats (El-Tarabany et al, 2017). According to Maitra et al (2014), the polymorphisms in KiSS1 gene may associate with sexual puberty, year-round estrus phenotypes, and high prolificacy in the goats.…”

Section: Introductionmentioning

confidence: 99%

Association of SNP T125A on KiSS1 gene with reproduction hormone levels in Kaligesing goat

Hardyta

Widayati

Maharani

2020

J. Indonesian Trop. Anim. Agric.

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The objective of this study was to assess the association of KiSS1 gene polymorphism with reproductive traits in Kaligesing goat. Genotypes of 48 ewes aged three years old were determined using PCR-RFLP and DNA sequencing. Sixteen out of 48 samples were monitored for the estrus cycle and determined their 17β-estradiol and progesterone levels using ELISA method. The results showed that KISS1 gene in the studied population was polymorphic with one single nucleotide polymorphism (SNP T125A). Then SNP was used to analyze genotype all individuals by PCR-RFLP method using MboII enzyme. Three genotypes (TT, TA and AA) were identified. Genotype frequencies of TA were 59.57%, AA were 40.43% while TT was not inculed in calculation for genetic diversity and assosication analysis since the number of genotype only one goat. The allele frequencies of T and A were 29.79% and 70.21%, respectively. The genotype distribution for the SNP was deviated from Hardy-Weinberg equilibrium (χ2=8.10; P<0.025). Hormonal analysis showed that the levels of 17β-estradiol in the follicular and luteal phase were 50.12±61.26 and 42.35±42.43 pg/ml, respectively, while the levels of progesterone hormone in the follicular and luteal phase were 7.87±10.59 and 12.39±15.93 ng/ml. No significant associations of the polymorphism were observed for any hormonal levels. However, it was first report about polymorfism in KiSS1 gene of local Indonesian goat especially Kaligesing goat.

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“…The breed, SNPs type and the position along the reference sequence and chromosome position are presented in Table 2. Several similar studies on KiSS-1 (intron 1) gene have identified several polymorphism in different goat populations (Cao et al, 2010;An et al, 2013b;Maitra et al, 2014a;El-Tarabany et al, 2017). Although these studies are focused on the non-coding regions of the gene it has been proven that mutations in intragenic (intron) regions may be involved in alternative splicing/regulation, transcript processing, gene expression and protein function, chromosomal rearrangement (Guey-Shin and Thomas, 2007;Sjakste et al, 2011) of varying phenotypes and have been found to affect economic traits (Jiang et al, 2010;Ibeagha-Awemu et al, 2014).…”

Section: Resultsmentioning

confidence: 95%

Sequencing, polymorphism and phylogenetic characterisation of KiSS-1 gene in two Nigerian indigenous goat breeds

et al. 2020

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KiSS-1 gene encodes a protein product kisspeptin which are intense inducers of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in various mammalian species through its receptor GPR54 (G protein-coupled receptor-54). A total of 100 goat compromising of Red Sokoto (n = 72) and Sahel (n = 28) breeds were used to detect single nucleotide polymorphisms (SNPs) in the intronic region of the KiSS-1 gene by sequencing and investigate their relationship with other goat breeds. Nucleotide sequence analysis revealed five novel SNPs (g.1745G>A present in Red Sokoto, g.1776G>A, g.1827A>G, g.1857T>C and g.2208T>C present in Red Sokoto and Sahel breeds). To obtain a correct phylogenetic relationship between goat breeds, nucleotide sequences were compared to other sequences in NCBI database using a BLASTn algorithm and retrieved for further analysis. Neighbour-joining phylogenetic relationship tree constructed revealed two distinct clusters with ancestral lineage of 100% identity. Nigerian goat breeds (Red Sokoto and Sahel) clustered into a clade with Indian goat breeds (Ganjam and Osmanabadi) while the second cluster involved eight other goat breeds. Genetic distance estimate revealed high genetic similarity between Red Sokoto and Sahel breeds as observed in their genetic distance value of 0.003. The nucleotide sequences of the two Nigerian goat breeds (Red Sokoto and Sahel) for KiSS-1 gene were submitted to GenBank database and have accession numbers: MN122316 and MN122317, respectively. The analysis of polymorphism in KiSS-1 gene indicates that genetic variation exists in the goat breeds studied. Therefore, attempts can be made to investigate the association of these polymorphism with reproductive traits in Nigerian goat breeds.

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Association analysis of polymorphism in KiSS1 gene with reproductive traits in goats

Cited by 21 publications

References 51 publications

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

Association of SNP T125A on KiSS1 gene with reproduction hormone levels in Kaligesing goat

Sequencing, polymorphism and phylogenetic characterisation of KiSS-1 gene in two Nigerian indigenous goat breeds

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