Association of SNP T125A on KiSS1 gene with reproduction hormone levels in Kaligesing goat

Hardyta, G.; Widayati, Diah Tri; Maharani, Dyah

doi:10.14710/jitaa.45.4.253-260

Cited by 6 publications

(6 citation statements)

References 27 publications

(40 reference statements)

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“…The hormone estrogen increases with follicle growth, as it is produced by granulosa cells that form the follicle wall (Ramli et al, 2016;Astuti et al, 2020). The results of this study are similar to research on the Kiss1 gene locus by Hardyta et al (2020) in kaligesing goats, which found no association between estradiol levels and the Kiss1 gene. Henceforth, studying the association of hormone concentrations in larger samples and at other SNP loci of the FSHR and PRL genes is necessary.…”

Section: Resultssupporting

confidence: 84%

“…Estradiol concentrations measured from 15 dairy cows during estrous obtained an average of 60.06±33.25 pg/ml. This result is almost the same as the estradiol concentrations during estrous reported in Bali cattle 55.00 ± 4.33 pg/ml (Suartini et al, 2013); 63.16 pg/ml (Laksmi and Trilaksana, 2020); in beef cattle 40.06 -67.80 pg/ml (Astuti et al, 2020); in SimPO cattle 69.30±27.20 pg/ml; dairy cattle 61.00 ±19 pg/ml (Firdausyia, 2018); and in kaligesing goats 50.12±61.26 pg/ml (Hardyta et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have reported polymorphisms of FSHR and PRL genes associated with reproductive traits in cows and goats (Sharifiyazdi et al, 2018;Gayari et al, 2020;Al-Thuwaini, 2021;Setyorini et al, 2023 a ). Reproductive properties are under the control of hypothalamicpituitary-gonadal balance (Hardyta et al, 2020). Follicle-stimulating hormone (FSH) is a glycoprotein hormone secreted by the anterior pituitary gland and has a vital role in male and female reproductive physiology (Das and Kumar, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Estradiol Concentrations During Estrous in Dairy Cattle and Its Association with Pregnancy and Genotype Diversity

Setyorini,

Edy Kurnianto,

Sutopo Sutopo

et al. 2023

Jurnal Sain Peternakan Indonesia

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This study determined estradiol concentrations during estrous in dairy cattle and its association with pregnancy and genotype diversity. A total of fifteen female dairy cows that had been identified with their genotype type using the PCR-RFLP method on follicle-stimulating hormone receptor (FSHR) and prolactin (PRL) genes were used in this study. The parameters measured were serum estrogen concentrations during estrous, estrous intensity, and pregnancy. Estradiol concentrations were analyzed by the enzyme-linked immunosorbent assay (ELISA) method. The data were analyzed using a general linear model procedure in the SAS program. The results showed that the average estradiol concentrations in dairy cows during estrous were 60.06±33.25 pg/ml. There was no difference (P>0.05) in estradiol concentrations in different classifications of age, body condition score (BCS), and estrous intensity. Estradiol concentrations in the group that showed success in post-insemination pregnancy were higher and significantly different (P<0.05) from the non-pregnant group. Differences in genotype variations of the FSHR and PRL genes had no significant effect (P>0.05) on the estradiol concentrations. In conclusion, estradiol concentrations during estrous were not associated with age, BCS, estrous intensity, and genotype diversity of FSHR and prolactin genes but were associated with pregnancy.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Estradiol Concentrations During Estrous in Dairy Cattle and Its Association with Pregnancy and Genotype Diversity

Setyorini,

Edy Kurnianto,

Sutopo Sutopo

et al. 2023

Jurnal Sain Peternakan Indonesia

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“…As a consequence of this, these SNPs have the potential to serve as novel molecular markers for determining the litter size of goat (Table 1). [12][13][14][15][16][17][18][19][20][21][22] Polymorphisms and frequency distributions of GDF9 gene The SNPs of GDF9 genes were identified, and litter size traits were analyzed in four Indonesian goats (Saanen, Bligon Kacang and Kejebong). The results of the PCR restriction fragment length polymorphism (RFLP) analysis revealed four new polymorphisms in all three GDF9 genes.…”

Section: Resultsmentioning

confidence: 99%

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

et al. 2023

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Background: Litter size (LS) is a significant, challenging, and economical aspect of the goat industry in Indonesia. It is influenced by several different factors and genes; consequently, identifying potential genes and loci associated with litter size has become a genetic problem. Several genetic indicators have been found to be associated with litter size in goats. This has prompted the need to discuss candidate genes associated with litter size in goats in Indonesia. Methods: A systematic review was conducted using critical databases including ResearchGate, Google Scholar, PubMed, Google search engine and Science direct. There were any exclusion criteria, they were as follows: articles published in languages other than English, Conference papers, short communication papers and papers not related to animals. After reviewing the abstracts of 42 publications, the remaining 17 investigations were chosen for full paper evaluation. A further eight studies were removed after a comprehensive evaluation of the publications because they did not match our inclusion criteria. Results: These markers include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor type IB (BMPR1B), and kisspeptin (KISS1). Single nucleotide polymorphisms in these genes contribute to the development of novel genetic markers that helps in the selection of goats with the most favorable genotypes for litter size. This type of genetic selection is more successful than the traditional way of selecting animals for reproductive traits, particularly litter size. Conclusions: As a result, this study summarizes the genetic impacts of polymorphisms in candidate genes associated with litter size features in Indonesian goats.

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“…Previous research in Indonesia characterized the polymorphisms of KISS1 gene intron 1 and exon 1 of Ettawa Grade (EG), although the researchers could not find the association with LS and other reproductive traits (Mulyono et al, 2019;Hardyta et al, 2020). However, to make the best use of limited selection funds, specific indigenous breeds must be prioritized for selection.…”

Section: Introductionmentioning

confidence: 99%

A Novel SNPs of KISS1 Gene Strongly Associated with Litter Size in Indonesian Goat Breeds

Febriana

Sutopo

Kurnianto

et al. 2022

Trop. Anim. Sci. J.

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Kisspeptin is a protein encoded by the KISS1 gene which behaves as a key role by stimulating gonadotropin releasing hormone (GnRH) neuron activity directly in the reproductive axis. The objective of the present study was to determine the genetic diversity within intron 1 of KISS1 gene and to verify their association with fecundity traits which can be devoted as a marker assisted selection (MAS) for breeding selection. This study was established on three Indonesian native goat populations (Kacang, Kejobong, and Senduro). The PCR products were then sequenced in both directions. The DNA sequencing alignment resulted fifteen variants (one indel and fourteen SNPs), with SNP1, SNP2, SNP3, and SNP9 being novel single nucleotide polymorphisms (SNPs) of KISS1 gene intron 1. Genotype, haplotype, and parity were significantly associated with litter size. SNP8, SNP9, and SNP10 were correlated with overall means of litter size (LS) and LS at the first and the third parities (p<0.05). Additionally, novel SNP9 were in remarkably strong linkage disequilibrium with SNP8 and SNP10 (D'=1.00; r≥0.58; χ 2 ≥13.38), and allele A had putative binding sites for the NFIC which plays an important role in activating the expression of KISS1 gene. The H2 haplotype (CATAGCGCAACGCT) was found to have the highest litter size (p<0.0001). CC genotype at SNP8, AA genotype at novel SNP9, GA genotype at SNP10, and H2 haplotype were the excellent genotypes and haplotype that associated with the superior LS (p<0.05). Therefore, this result led to presume that these three SNPs and H2 haplotype can be acknowledged as prominent genetic markers for goatbreeding selection.

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Association of SNP T125A on KiSS1 gene with reproduction hormone levels in Kaligesing goat

Cited by 6 publications

References 27 publications

Estradiol Concentrations During Estrous in Dairy Cattle and Its Association with Pregnancy and Genotype Diversity

Estradiol Concentrations During Estrous in Dairy Cattle and Its Association with Pregnancy and Genotype Diversity

Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review

A Novel SNPs of KISS1 Gene Strongly Associated with Litter Size in Indonesian Goat Breeds

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