Association analysis of FTO gene polymorphisms rs9939609 and obesity risk among the adults: A systematic review and meta-analysis

Ali, Alaa Hashim Abd; Шкурат, Т. П.; Abbas, Ali Hafedh

doi:10.1016/j.mgene.2020.100832

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…In the literature, there have also been some contradictions about these dependencies on the individual gene polymorphisms, mainly due to variability, which could be the results of different frequencies of MAF in the selected ethnic groups. What is more, some studies show the influences of variants of FTO on the risk of cardiovascular diseases [ 10 , 11 , 12 , 13 , 14 , 15 , 20 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

FTO Gene Polymorphisms and Their Roles in Acromegaly

Jawiarczyk-Przybyłowska

Kuliczkowska-Płaksej

Kolačkov

et al. 2023

IJMS

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The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four FTO gene polymorphisms with selected parameters of lipid and glucose metabolism as well as with IGF-1 and GH levels in the group of patients with acromegaly compared to the control group. The study group consisted of 104 patients with acromegaly and 64 healthy subjects constituting the control group. In the whole acromegaly group, the data reveal that the homozygous for risk allele carriers (rs1421085, rs9930506, rs9939609) as well as carriers of only one risk allele have lower IGF-1 concentrations. In the well-controlled acromegaly group, the homozygous for three risk allele carriers of FTO gene polymorphisms have lower HDL cholesterol concentration (rs1121980, rs1421085, rs993609). In the cured acromegaly group, homozygous risk allele carriers rs9930506 tend to have higher levels of total cholesterol and LDL cholesterol. These associations are not observed in the control group. Conclusion: there is an association between FTO gene polymorphisms and the metabolism of lipids, suggesting that the FTO gene may be associated with higher CVD risk in patients with acromegaly. In addition, there is an association between FTO gene polymorphisms and IGF-1, implying that FTO gene may influence/modify IGF-1 synthesis. Further investigation on a larger scale is required to provide more precise evidence.

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Section: Discussionmentioning

confidence: 99%

FTO Gene Polymorphisms and Their Roles in Acromegaly

Jawiarczyk-Przybyłowska

Kuliczkowska-Płaksej

Kolačkov

et al. 2023

IJMS

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“…The rs9939609 polymorphism correlates with physical activity and food intake and may sedentary lifestyles and eating problems has been shown to affect the prevalence of obesity [40][41][42] . The presence of the FTO gene genotypes TA and AA shows that allele A predicts the risk of higher FTO gene expression, including in children 43,44 . A further study found a link between in the Nigerian population, the rs9939609 polymorphism allele A is associated with increased obesity risk (p < 0.001) 45 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents

Ali

Teplyakova²,

Bocharova³

et al. 2022

Baghdad Sci.J

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Obesity is a risk factor for a number of chronic conditions. Obesity is clinically defined using the body mass index (BMI) as weight in kg divided by (height)2 in m2 correlated with obesity. Currently, genetic markers of obesity are being studied. This study focused on the association between the angiotensin II receptor AGTR1 gene (A1166C) and fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase (FTO) (rs9939609) in obese children and adolescents patients in Rostov region, Russia. Five-hundreds of Russian nationality child and adolescent were recruited for the obesity-control studies. The relationship between the A1166C polymorphism of the AGTR1 gene in 300 children and adolescents included as the unhealthy group, compared with healthy group of 200 participants were investigated. Genotyping of A1166C polymorphisms of the AGTR1 rs5186 gene was performed using PCR allele-specific primers. Polymorphisms of the AGTR1 A1166C (rs5186) genes in donor DNA samples were typed by the electrophoretic method using commercial test systems from the Lytech research and production company. The relationship between obesity and AGTR1 gene polymorphism (A1166C) was not established between the obesity and control groups in terms of the frequency of occurrence of the CC genotype (P = 1.000) and (OR 1.05; 95% CI (0.53 – 2.10)) and the C allele (P = 0.942) and (OR 1.01; 95% CI (0.76 – 1.35)). However, in the occurrence of frequency genotype of AA (P = 0.003; OR 0.57; 95% CI (0.39 – 0.82)) and T (P = 0.006) of allele and (OR 1.44; 95% CI (1.11 – 1.87)) the rs9939609 of the FTO gene were revealed differences (P <0.05) between patients and control groups. The association between genotypes obesity risk was indicated, and a significant relationship was shown between the occurrence of obesity with the FTO rs9939609 polymorphism.

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“…There is evidence that the microbiome may influence cancer risk via epigenetic mechanisms. For example, supplementation with probiotics during pregnancy positively modulated the methylation of obesity risk genes in infants, including reduced methylation of the gene encoding methionine sulfoxide reductase (MSRA), which may have a tumour-suppressive effect in non-small cell lung and breast cancers [ 49 ]. Whilst the effects of early life exposures on the microbiome are now well-established, more research is needed on the legacy of such exposures for the microbiome in adulthood [ 113 ] and, in particular, on how they may modulate cancer risk.…”

Section: The Role Of the Gut Microbiome (Microbiomics) In Cancer Risk...mentioning

confidence: 99%

“…The situation is less clear for other health-related outcomes. Since the fat-mass and obesity-associated ( FTO ) risk allele is associated with higher body weight and greater risk of obesity [ 49 ], one might expect that this genotype would make it more difficult for those overweight or obese to lose weight. Contrary to that hypothesis, participants in the Food4Me Study who carried the FTO risk allele showed greater reductions in body weight and in waist circumference (WC) than were observed in those with the non-risk genotype [ 50 ].…”

Section: Introduction To Personalised and Precision Nutritionmentioning

confidence: 99%