Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients

Fontana, Maria Luiza S. Simas Netta; Souza, Cleber Machado de; Bernardino, José Fábio; Hoette, Felix; Hoette, M.; Thum, Lotario; Ozawa, Terumi Okada; Filho, Leopoldino Capelozza; Olandoski, Márcia; Trevilatto, Paula Cristina

doi:10.1016/j.ajodo.2012.04.013

Cited by 42 publications

(62 citation statements)

References 56 publications

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“…The results of the present review suggest that although some authors have reported that genetic polymorphism may play a role in EARR, [4][5][6][7][8][9][20][21][22][23]24 others have not supported this association. [25][26] Published orthodontic investigations in gene studies have seldom adhered to the STREGA or any genetic guidelines.…”

Section: Summary Of Evidencecontrasting

confidence: 46%

Association of genetic polymorphism and external apical root resorption

Aminoshariae

Valiathan

et al. 2016

The Angle Orthodontist

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Objective: To evaluate the relationship between genetic polymorphism and external apical root resorption. Methodology: The protocol was prepared and registered on PROSPERO. Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies of all relevant articles and textbooks were manually searched. Results: Thirteen studies met the inclusion criteria. Four studies were classified as low-quality studies (score ,10), and nine studies were classified as high-quality studies. Discussion: The results of the present review suggest that, although some authors have reported that genetic polymorphism may play a role in external apical root resorption, others have not supported this association. Future studies should be more consistent in their research methodologies to determine with clarity whether an association exists. Conclusion: Future investigations should include larger sample sizes with matching cases/ controls, adjust for confounders, provide power calculation and odds ratios, and report genetic analyses with the Hardy-Weinberg equilibrium. The current investigation suggests guidelines and recommendations for future investigators studying genetic polymorphism in patients undergoing orthodontic treatment. (Angle Orthod. 2016;86:1042-1049

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Section: Summary Of Evidencecontrasting

confidence: 46%

Association of genetic polymorphism and external apical root resorption

Aminoshariae

Valiathan

et al. 2016

The Angle Orthodontist

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“…53 Human studies relating the vitamin D receptor Taql polymorphism with external apical root resorption found that genotypes containing the C allele were weakly associated with protection against external apical root resorption in orthodontic patients. 54 Sib-pair linkage and parentschild trio association studies found that genetic factors play marked roles in OIIRR, accounting for half to two thirds of the interindividual variations. 55 Similar results were obtained, with significant statistical differences among the frequencies of the alleles and genotypes of the IL-1beta gene polymorphism between the affected and unaffected groups, suggesting that the polymorphism of the IL-1beta gene is associated with root resorption in the studied population.…”

Section: Discussionmentioning

confidence: 99%

Physical properties of root cementum: Part 25. Extent of root resorption after the application of light and heavy buccopalatal jiggling forces for 12 weeks: A microcomputed tomography study

Eross

Türk

Elekdağ-Türk

et al. 2015

American Journal of Orthodontics and Dentofacial Orthopedics

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“…VDR genetic polymorphisms have been associated with bone mineral density (49,50) and in immune function (51,52). Furthermore, genetic polymorphisms in VDR have been associated with oral conditions (53)(54)(55)(56). The genetic polymorphism rs731236 was associated with external apical root resorption in orthodontic patients (54).…”

Section: Discussionmentioning

confidence: 99%

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

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This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP.

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Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients

Cited by 42 publications

References 56 publications

Association of genetic polymorphism and external apical root resorption

Association of genetic polymorphism and external apical root resorption

Physical properties of root cementum: Part 25. Extent of root resorption after the application of light and heavy buccopalatal jiggling forces for 12 weeks: A microcomputed tomography study

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

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