Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women

Choi, Kyung Mook; Lee, K.W.; Kim, H.Y.; Seo, J-H; Kim, S.G.; Kim, N.H.; Choi, Deuk-Soo; Baik, Sei-Hyun

doi:10.1016/j.metabol.2005.05.018

Cited by 53 publications

(41 citation statements)

References 34 publications

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“…We found a strong positive correlation between ferritin and the hepatic enzymes, ALT and GGT (r ranging between 0.29 and 0.37, p<0.0001). This is consistent with the recently reported correlation of 0.37 (p<0.001) between ALT and serum ferritin among 959 women in a cross-sectional Korean study [27]. It is plausible that iron overload in the liver damages hepatocytes, which in turn would result in elevated transaminases and GGT.…”

Section: Discussionsupporting

confidence: 92%

Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

et al. 2007

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Aims/hypothesis The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes. Subjects and methods We studied the association between baseline serum ferritin concentration and type 2 diabetes in 360 clinically incident diabetes cases and 758 controls nested within the EPIC (European Prospective Investigation of Cancer)-Norfolk Cohort Study. Serum ferritin levels were categorised into five groups: sex-specific quartiles of the normal range of ferritin and a group with clinically raised ferritin below levels indicative of haemochromatosis. Results Baseline serum ferritin was higher among cases than control participants (geometric mean: men 96.6 vs 67.8 ng/ml, respectively, p<0.001; women 45.9 vs 34.8 ng/ ml, respectively, p=0.005). In analyses adjusted for known risk factors (age, BMI, sex, family history, physical activity, smoking habit) and dietary factors measured by 7-day food diary, the risk of diabetes was markedly elevated in participants with clinically raised ferritin compared with the lowest quartile (odds ratio [OR] 7.4, 95% CI 3.5-15.4). Further adjustment for potential confounding by inflammation (C-reactive protein, IL-6 and fibrinogen) had no material impact on the observed association, while adjustment for hepatic enzymes (alanine aminotransferase and γ glutamyl transferase) and adiponectin attenuated the magnitude of association, but it remained statistically significant (OR 3.2 [1.3-7.6]). Conclusions/interpretation Serum ferritin is an important and independent predictor of the development of diabetes. This finding may have important implications for understanding the aetiology of diabetes.

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Section: Discussionsupporting

confidence: 92%

Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

et al. 2007

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“…An experimental study showed that the intracellular iron chelator desferrioxamine inhibited inflammation and atherosclerosis in mice, suggesting that iron may play a role in atherogenesis. 16 Elevated iron stores may impose oxidative injury and have been associated with inflammation, 17,18 insulin resistance, 19,20 the metabolic syndrome, 21 and type 2 diabetes. 22 Red meat is *Adjusted for age, smoking status and pack-years of smoking, education, body mass index, total physical activity, history of diabetes, history of hypertension, aspirin use, family history of myocardial infarction, and intake of total energy, alcohol, coffee, fish, fruits, and vegetables.…”

Section: Discussionmentioning

confidence: 99%

Red Meat Consumption and Risk of Stroke in Swedish Women

Larsson

Virtamo

Wolk

2011

Stroke

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Background and Purpose-High red meat consumption has been associated with increased risk of some cancers and may also be a risk factor for cardiovascular diseases. However, epidemiological studies of red meat consumption in relation to risk of stroke are very limited. Our objective was to examine the association between red meat consumption and stroke incidence in the Swedish Mammography Cohort. Methods-We prospectively followed 34 670 women without cardiovascular disease and cancer at baseline. Participants completed a self-administered questionnaire on diet and other risk factors for cardiovascular diseases in 1997. Cox proportional hazards models were used to estimate multivariable-adjusted relative risks (RR) and 95% CI. Results-During a mean follow-up of 10.4 years, we ascertained 1680 incident cases of stroke, comprising 1310 cerebral infarction, 154 intracerebral hemorrhage, 79 subarachnoid hemorrhage, and 137 unspecified stroke. Total red meat and processed meat consumption was associated with a statistically significant increased risk of cerebral infarction, but not of total stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The multivariable RR of cerebral infarction for the highest versus the lowest quintile of consumption were 1.22 (95% CI, 1.01-1.46) for red meat and 1.24 (95% CI, 1.04 -1.49) for processed meat. Fresh (unprocessed) meat consumption was not associated with total stroke or with any stroke subtype. Conclusion-Findings from this study suggest that red and processed meat consumption may increase the risk of cerebral infarction in women. (Stroke. 2011;42:324-329.)

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“…Elevations of transaminase are common in patients with fatty liver with or without histological evidence of inflammation. 20 -24 In addition, higher levels of serum transaminases in populations have been associated with the metabolic syndrome [25][26][27][28][29][30] and a higher risk for CVD. 31,32 Other lines of evidence support a relationship between elevated serum GGT and the metabolic syndrome.…”

mentioning

confidence: 99%

Gamma-Glutamyl Transferase

Grundy

2007

ATVB

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Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women

Cited by 53 publications

References 34 publications

Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

Red Meat Consumption and Risk of Stroke in Swedish Women

Gamma-Glutamyl Transferase

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