Associated conditions in patients with multiple dermatofibromas: Case reports and literature review

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

“…published the most recent literature review of multiple DFs. They reviewed 37 cases and found that several conditions and medications could be associated with multiple DFs, including pregnancy, Down syndrome, hypertriglyceridemia, hematologic malignancies, HIV infection, myasthenia gravis, pemphigus vulgaris, SLE, immunosuppressive agents, psoriasis therapies, and antineoplastic drugs [60]. The present research reviews 106 cases including 24 new studies that have since been published.…”

“…The incidences of underlying diseases, including SLE, HIV infection, and hematologic malignancies, among multiple DF and MEDF patients were about 83 % and 91 %, respectively. Although previous studies suggest that immune‐mediated conditions such as atopic dermatitis, myasthenia gravis, and pemphigus vulgaris were frequently seen in multiple DF patients [60], we identified only three patients with these diseases. Interestingly, some cases reported the appearance of DF lesions before underlying conditions were diagnosed.…”

Disseminated brown papules on the trunk and extremities of an elderly man

“…The biggest challenge in this case is to differentiate MCAH from DF, as the lesions were almost indistinguishable clinically from the asymptomatic, firm, hyperpigmented DF lesions when examined singly. If multiple DF lesions occur (usually 15 or more), it is considered to be a clinical variant called multiple eruptive dermatofibroma (MEDF), which is often associated with underlying immune-related disorders such as systemic lupus erythematosus or HIV infection [9]. Multinucleate cells and vascular proliferation could Table 1 The key features that help with differentiation between dermatofibroma and multinucleate cell angiohistiocytoma.…”

Plaque-Like Dermatofibroma: Case Report of a Rare Entity

“…The origin of dermatofibromas is unclear. A cause related to an immune process or to immunosuppressive medication has been suggested based on the observation that a subgroup of dermatofibromas occurring as multiple, widespread eruptive lesions are often associated with an autoimmune disease, most commonly lupus erythematosus [31,32]. In these patients, the dermatofibromas show a wide anatomic distribution without clustering.…”