An efficient asymmetric Mannich-type reaction between α-tetralone-derived β-keto esters/amides and 1,3,5-triaryl-1,3,5-triazinanes was realized catalyzed by chiral N,N'–dioxide-Ni(ii)/Mg(ii) complexes.

Juvenile xanthogranuloma is a benign histiocytic skin disorder encountered primarily in infancy and childhood. Approximately 0.4% of cases exhibit ocular manifestations, which can result in glaucoma and blindness. We present a case of a 7-month-old male with unilateral glaucoma associated with Juvenile xanthogranuloma, and emphasize the importance of an ocular screening in patients with Juvenile xanthogranuloma, especially those with periocular lesions.

Ah ighly enantioselective formal conjugate allyl addition of allylboronic acids to b,g-unsaturated a-ketoesters has been realized by employing ac hiral Ni II /N,N'-dioxide complex as the catalyst. This transformation proceeds by an allylboration/oxy-Cope rearrangement sequence,p roviding af acile and rapid route to g-allyl-a-ketoesters with moderate to good yields (65-92 %) and excellent ee values (90-99 %ee). The isolation of 1,2-allylboration products provided insight into the mechanism of the subsequent oxy-Cope rearrangement reaction:s ubstrate-induced chiral transfer and ac hiral Lewis acid accelerated process.Based on the experimental investigations and DFT calculations,arare boatlike transition-state model is proposed as the origin of high chirality transfer during the oxy-Cope rearrangement.

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A highly enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with α-ketoesters and isatins has been realized by using a chiral N,N'-dioxide/Mg(II) complex. In the presence of only 0.1-0.5 mol % catalyst, a series of substrates were transformed into the corresponding tetrasubstituted 2,3-dihydropyran-4-ones in up to 99 % yield and more than 99 % ee in two hours.

Left atrial myxoma was diagnosed in a 42-year-old woman who had cutaneous and neurological manifestations without cardiac symptoms or signs. A two-dimensional echocardiogram revealed an orange-sized mobile mass in the left atrium. Magnetic resonance imaging showed multiple cerebral infarctions. Cardiac surgery for removal of the left atrial myxoma was successful and histopathology confirmed myxoma. Cutaneous and neurological manifestations were improved after the operation. Early surgical intervention may prevent the onset of severe neurological deficits in such patients.

Atrophia maculosa varioliformis cutis (AVMC) was first described in 1918, as a rarely reported form of idiopathic macular atrophy on the cheeks. Nineteen patients have been reported in the past 86 years. Recently we diagnosed a 25-year-old woman as AMVC and investigated her family history. We collected the clinical data of the pedigree and presumed that AVMV is in a autosomal dominant inheritance.